Brain disorders Clinical Trials in Boston, MA

As of June 2026, 149 paid clinical trials are recruiting for Brain disorders in Boston, Massachusetts. Brain disorder trials span neurodegenerative diseases, stroke, traumatic brain injury, and neuromuscular conditions — testing both pharmacologic and rehabilitative approaches to slow progression and improve function. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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149 clinical trials for Brain disorders

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Treating Insomnia in Mild Cognitive Impairment

for Mild Cognitive Impairment (MCI)

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 60+

Code: NCT06687161·Recruiting

Apply to this trial

Treating Parkinson's Disease Through Transplantation of Autologous Stem Cell-Derived Dopaminergic Neurons

for Parkinson Disease

1 location in Boston

Sponsor: Jeffrey S. Schweitzer, MD, PhD

Sex: All·Age: 45 - 80

Code: NCT06687837·Phase 1·Recruiting

Apply to this trial

A Study to Investigate Multiple Sclerosis Relapse Prevention With mRNA-1195 Compared With Placebo in Participants Aged 18 to ≤55 Years

for Multiple Sclerosis

8 locations incl. Boston

Sponsor: ModernaTX, Inc.

Sex: All·Age: 18 - 55

Code: NCT06735248·Phase 2·Recruiting

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Vascular Mechanisms, Functional Outcomes, & Exercise Among Persons With Multiple Sclerosis With Hypertension

for Multiple Sclerosis

1 location in Boston

Sponsor: University of Massachusetts, Boston

Sex: All·Age: 18+

Code: NCT06554340·Recruiting

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The DIAGNOSE CTE Research Project-II

for Chronic Traumatic Encephalopathy (CTE)

5 locations incl. Phoenix

Sponsor: Boston University

Sex: Male·Age: 50+·Accepts healthy volunteers

Code: NCT06860828·Enrolling By Invitation

TMS for Cognitive Decline in Aging and Preclinical AD

for Prodromal Alzheimer&#39

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 40 - 99·Accepts healthy volunteers

Code: NCT06956300·Recruiting

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Effectiveness of Cognitive Training in Older and Younger Adults

for Cognitive Change

3 locations incl. Riverside

Sponsor: University of Wisconsin, Madison

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT06375681·Recruiting

Apply to this trial

Novel Wrist Sensor System to Promote Hemiparetic Arm Use in Home Daily Life of Chronic Stroke Survivors

for Stroke

1 location in Boston

Sponsor: Spaulding Rehabilitation Hospital

Sex: All·Age: 18 - 85

Code: NCT05626894·Phase 2·Recruiting

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EIM Via the Myolex mScan as an ALS Biomarker

for Amyotrophic Lateral Sclerosis

6 locations incl. Phoenix

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT06491732·Recruiting

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Assessment of a Physio-neuro Platform (SynPhNe) for Home-based Retraining of Hand Function in Stroke Survivors

for Stroke

1 location in Boston

Sponsor: Spaulding Rehabilitation Hospital

Sex: All·Age: 21 - 80

Code: NCT02896348·Recruiting

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A Randomized Study of SPK-10001 Gene Therapy in Participants With Huntington's Disease

for Huntington Disease

5 locations incl. Boston

Sponsor: Hoffmann-La Roche

Sex: All·Age: 25 - 65

Code: NCT06826612·Phase 1, Phase 2·Recruiting

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Study of LHP588 in Subjects With P. Gingivalis-Positive Alzheimer's Disease

for Alzheimer Disease

40 locations incl. Phoenix

Sponsor: Lighthouse Pharmaceuticals, Inc.

Sex: All·Age: 55 - 80

Code: NCT06847321·Phase 2·Recruiting

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A Study to Investigate the Efficacy, Safety and Tolerability of Remibrutinib Versus Placebo in Adult Patients With Generalized Myasthenia Gravis

for Generalized Myasthenia Gravis

Drug: Remibrutinib

24 locations incl. Phoenix

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 75

Code: NCT06744920·Phase 3·Recruiting

Apply to this trial

StrokeNet Thrombectomy Endovascular Platform

for Ischemic Stroke

41 locations incl. Birmingham

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06289985·Recruiting

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Mindfulness for Cognition in Early-stage Alzheimer's Disease

for Mild Cognitive Impairment (MCI)

1 location in Boston

Sponsor: VA Boston Healthcare System

Sex: All·Age: 50 - 100·Accepts healthy volunteers

Code: NCT06792877·Recruiting

Apply to this trial

A Phase 2 Study and Open-Label Extension of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Disease

for Parkinson Disease

45 locations incl. Sun City

Sponsor: Neuron23 Inc.

Sex: All·Age: 40 - 80

Code: NCT06680830·Phase 2·Recruiting

Apply to this trial

Healthy Aging as Black Adults, In It Together: a Comparative Effectiveness Study of Chronic Pain and Cognitive Decline

for Chronic Pain

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 50+

Code: NCT06246929·Recruiting

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RAPA-501 Therapy for ALS

for Amyotrophic Lateral Sclerosis

1 location in Boston

Sponsor: Rapa Therapeutics LLC

Sex: All·Age: 18+

Code: NCT04220190·Phase 2, Phase 3·Recruiting

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Genetic and Environmental Risk Factors for Hemorrhagic Stroke

for Stroke

7 locations incl. Chicago

Sponsor: State University of New York at Buffalo

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT00682695·Recruiting

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Leveraging Social Networks to Improve Sleep and Mindfulness Among Older Adults in Residential Housing Facilities

for Aging

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 55+·Accepts healthy volunteers

Code: NCT06989619·Recruiting

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A Non-interventional, Post-authorisation Safety Study of Patients Treated With Efgartigimod Alfa

for Myasthenia Gravis

17 locations incl. San Francisco

Sponsor: argenx

Sex: All·Age: 18+

Code: NCT06298565·Recruiting

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A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)

for Alzheimer Disease

Drug: KarXT

98 locations incl. Chandler

Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Sex: All·Age: 55 - 90

Code: NCT06585787·Phase 3·Recruiting

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A Safety, Tolerability, and Preliminary Efficacy of Low-intensity Focused Ultrasound Neuromodulation in Patients With Drug-resistant Epilepsy

for Drug Resistant Epilepsy

3 locations incl. Palo Alto

Sponsor: NaviFUS Corporation

Sex: All·Age: 18+

Code: NCT06388707·Phase 1, Phase 2·Recruiting

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Frequency of Selected Single Nucleotide Polymorphisms in Huntington Disease Gene Expansion Carriers

for Huntington Disease

13 locations incl. Birmingham

Sponsor: Hoffmann-La Roche

Sex: All·Age: 25 - 60

Code: NCT06667414·Recruiting

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Autologous iPSC-Derived Dopamine Neuron Transplantation for Parkinson's Disease

for Parkinson Disease

1 location in Boston

Sponsor: Penelope J. Hallett, Ph.D.

Sex: All·Age: 55 - 80

Code: NCT06422208·Phase 1·Enrolling By Invitation

Multi-Arm Multi-Stage Adaptive Platform Trial (APT) for the Acute Treatment of Traumatic Brain Injury

for Traumatic Brain Injury

18 locations incl. San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 18 - 65

Code: NCT05826912·Phase 2·Enrolling By Invitation

A Phase III Study to Investigate Efficacy, Safety and Tolerability of Iptacopan Compared With Placebo in Participants Aged 18 to 85 Years With gMG.

for Generalized Myasthenia Gravis

Drug: Iptacopan

21 locations incl. Scottsdale

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 85

Code: NCT06517758·Phase 3·Recruiting

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ASSESS ALL ALS Study

for Amyotrophic Lateral Sclerosis

31 locations incl. Birmingham

Sponsor: St. Joseph's Hospital and Medical Center, Phoenix

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06578195·Recruiting

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PREVENT ALL ALS Study

for Amyotrophic Lateral Sclerosis

31 locations incl. Birmingham

Sponsor: St. Joseph's Hospital and Medical Center, Phoenix

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06581861·Recruiting

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A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)

for Relapsing Multiple Sclerosis

87 locations incl. Birmingham

Sponsor: TG Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06433752·Recruiting

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Dance and Energy Expenditure Among Adults With Parkinson's

for Parkinson Disease

1 location in Boston

Sponsor: Northeastern University

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT06425731·Recruiting

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A Retrospective Survey-based Multicenter Study to Delineate the Molecular and Phenotypic Spectrum of Epilepsy-dyskinesia Syndromes

for Epilepsy in Children

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 0 - 18

Code: NCT06585605·Recruiting

Apply to this trial

Dalfampridine Combined With Physical Therapy for Mobility Impairment in Multiple Sclerosis

for Multiple Sclerosis

1 location in Boston

Sponsor: MGH Institute of Health Professions

Sex: All·Age: 25 - 75

Code: NCT06136728·Phase 4·Recruiting

Apply to this trial

A Study of AAV2-GDNF in Adults With Moderate Parkinson's Disease (REGENERATE-PD)

for Parkinson Disease

27 locations incl. Irvine

Sponsor: AskBio Inc

Sex: All·Age: 45 - 75

Code: NCT06285643·Phase 2·Recruiting

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A Study to Evaluate the Safety, Tolerability, Efficacy, and Drug Levels of CC-97540 in Participants With Relapsing Forms of Multiple Sclerosis, Progressive Forms of Multiple Sclerosis or Refractory Myasthenia Gravis (MG) (Breakfree-2)

for Multiple Sclerosis

17 locations incl. Birmingham

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18 - 60

Code: NCT06220201·Phase 1·Recruiting

Apply to this trial

Strategy for Improving Stroke Treatment Response

for Ischemic Stroke

52 locations incl. Birmingham

Sponsor: Translational Sciences, Inc.

Sex: All·Age: 18+

Code: NCT05948566·Phase 2·Recruiting

Apply to this trial

Gamma Light and Sound Stimulation to Prevent Dementia in Cognitively Normal People At Risk for Alzheimer's Disease

for Alzheimer Disease

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 55 - 90·Accepts healthy volunteers

Code: NCT05776641·Recruiting

Apply to this trial

Pilot Study of Neurofeedback for Photosensitivity in Mild Traumatic Brain Injury

for Mild Traumatic Brain Injury

1 location in Boston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 65

Code: NCT06109909·Recruiting

Apply to this trial

Improving Memory in Alzheimer's Disease With Noninvasive Brain Stimulation

for Alzheimer Disease

1 location in Boston

Sponsor: Boston University Charles River Campus

Sex: All·Age: 50 - 100·Accepts healthy volunteers

Code: NCT06094192·Recruiting

Apply to this trial

Treatment With Endovascular Intervention for STroke Patients With Existing Disability

for Stroke

25 locations incl. Phoenix

Sponsor: University of Cincinnati

Sex: All·Age: 18+

Code: NCT05911568·Recruiting

Apply to this trial

Conditions in Brain disorders (Boston, MA)

Stroke· 29 Alzheimer's disease· 22 Parkinson's disease· 22 Epilepsy· 17 Multiple sclerosis· 16 ALS (amyotrophic lateral sclerosis)· 15 Mild cognitive impairment (MCI)· 12 Dementia· 10 Cognitive impairment / decline· 9 Myasthenia gravis· 7 Traumatic brain injury (TBI)· 5 Essential tremor· 4 Huntington disease· 3