Frequency of Selected Single Nucleotide Polymorphisms in Huntington Disease Gene Expansion Carriers

Part of paid clinical trials in Birmingham, Alabama.

Sponsor
Hoffmann-La Roche
Study ID
NCT06667414
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
25 Years - 60 Years
Healthy Volunteers
Not accepted

Study Details

For participation in this epidemiological study, a single-day visit at the study site is required. Participants will be recruited from Huntington Disease clinics, and they will be asked to answer questions regarding their demographics, including sex, age, race and ethnicity, and their medical and medication history. At the end of the visit, a blood sample will be drawn to allow testing with a sequencing assay that is specifically designed for phasing single nucleotide polymorphisms (SNPs) on the wild-type Huntington (wtHTT) and mutant Huntington (mHTT) alleles.

Key Dates

Start date
Sep 2, 2024
Status verified
May 2026
Primary completion
Feb 28, 2027
Completion
Feb 28, 2027

Study Design

Enrollment
600 participants (estimated)

Arms

  • Arm: Participants Who Are Huntington Disease Gene Expansion Carriers

Primary Outcome Measure

Frequencies of Selected Single Nucleotide Polymorphism (SNP) Alleles in Phase With the mHTT and wtHTT Alleles [ Time Frame: Day 1 ]

Central Contacts

  • Reference Study ID Number: WE45491 https://forpatients.roche.com/
    888-662-6728 (U.S. Only)
    [email protected]
  • Fastest response: use the inquiry form. No email attachments. https://www.gene.com/contact-us/submit-medical-inquiry

Locations (13)

FacilityCityStateZIPSite coordinators
Uab MedicineBirminghamAlabama35294-
Barrow Neurological InstitutePhoenixArizona85013-
University of California San DiegoLa JollaCalifornia92037-1337-
University of California Davis Medical SystemSacramentoCalifornia95817-
CenExel Rocky Mountain Clinical Research, LLCEnglewoodColorado80113-
University of South FloridaTampaFlorida33612-
Northwestern UniversityChicagoIllinois60611-
University of Iowa Hospitals and ClinicsIowa CityIowa52242-
John Hopkins University School of MedicineBaltimoreMaryland21287-
Beth Israel Deaconess Medical CenterBostonMassachusetts02215-
University of PittsburghPittsburghPennsylvania15213-
Vanderbilt University Medical CenterNashvilleTennessee37212-
EvergreenHealth Investigational Drug ServicesKirklandWashington98034-

Find similar trials in Birmingham, AL

By condition
Huntington disease
By specialty
NeurologyBrain disorders
By research site
Uab Medicine· Birmingham, ALBarrow Neurological Institute· Phoenix, AZUniversity of California San Diego· La Jolla, CAUniversity of California Davis Medical System· Sacramento, CACenExel Rocky Mountain Clinical Research, LLC· Englewood, COUniversity of South Florida· Tampa, FL

Related Studies