Treatment With Endovascular Intervention for STroke Patients With Existing Disability

Part of paid clinical trials in Phoenix, Arizona.

Sponsor: University of Cincinnati
Study ID: NCT05911568
Status: Recruiting

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Conditions

Stroke
Stroke, Acute
Stroke, Ischemic

Eligibility Criteria

Sex: ALL
Age: 18 Years - N/A
Healthy Volunteers: Not accepted

Interventions

Endovascular Stroke Treatment — PROCEDURE
Patients who receive endovascular stroke treatment when they are admitted into the hospital, as determined by their clinical care team. Endovascular stroke treatment consist of catheter-based treatment for the blood clot causing the acute ischemic stroke
Medical Management — OTHER
Patients who receive MMM when they are admitted into the hospital, as determined by their clinical care team. MMM may involve any combination of the following: intravenous thrombolysis, antiplatelets, anti-hypertensives, cholesterol-lowering medications, and rehabilitative care. Specifically, this treatment does not involve endovascular stroke treatment.

Study Details

TESTED will compare the risks and benefits of endovascular thrombectomy (EVT) to medical management (no EVT) in ischemic stroke patients who have a blockage in one of the large blood vessels in the brain and have a moderate-to-severe disability prior to their stroke.

Key Dates

Start date: Nov 16, 2023
Status verified: Apr 2026
Primary completion: Jan 15, 2028
Completion: Apr 15, 2028

Study Design

Enrollment: 1,060 participants (estimated)

Arms

Arm: Stroke patients with moderate-to-severe pre-stroke disability
Patients with pre-stroke modified Rankin scale score 3 or 4, presenting with a anterior circulation large vessel occlusion stroke within 24 hours of last known well

Primary Outcome Measure

modified Rankin Scale (mRS) [ Time Frame: 90 (±14) days after treatment initiation ]

Central Contacts

Eva Mistry, MD
513-558-1291
[email protected]
Naima Griffin
513-558-0125
[email protected]

Locations (25)

Facility	City	State	ZIP	Site coordinators
HonorHealth	Phoenix	Arizona	85013	Ashu Jadhav, MD Ashu Jadhav, MD (PRINCIPAL_INVESTIGATOR)
Kaiser Permanente Los Angeles Medical Center	Los Angeles	California	90027	Shayandokht Taleb, MD Shayandokht Taleb, MD (PRINCIPAL_INVESTIGATOR)
University of California at Los Angeles	Los Angeles	California	90095	Jeffrey Saver, MD Jeffrey Saver, MD (PRINCIPAL_INVESTIGATOR)
Standford	Palo Alto	California	94305	Maarten Lansberg, MD
University of Cincinnati San Diego	San Diego	California	92121	Brett Meyer, MD
Swedish Medical Center	Englewood	Colorado	80113	Donald Frei, MD Donald Frei, MD (PRINCIPAL_INVESTIGATOR)
Hartford Health Hospital	Hartford	Connecticut	06106	Tapan Mehta, MD Tapan Mehta, MD (PRINCIPAL_INVESTIGATOR)
Yale University	New Haven	Connecticut	06510	Adam DeHavenon, MD Adam DeHavenon, MD (PRINCIPAL_INVESTIGATOR)
University of Miami	Miami	Florida	33125	Robert Starke, MD Robert Starke, MD (PRINCIPAL_INVESTIGATOR)
Emory University	Atlanta	Georgia	30322	Brian Howard, MD Brian Howard, MD (PRINCIPAL_INVESTIGATOR)
University of Chicago	Chicago	Illinois	60637	James Siegler, MD
University of Louisville	Louisville	Kentucky	40202	Isaac Josh Abecassis
Boston Medical Center	Boston	Massachusetts	02118	Mohamad AbdalKader, MD Mohamad AbdalKader (PRINCIPAL_INVESTIGATOR)
Barnes Jewish Hospital	Saint Loius	Missouri	63110	Charles Kircher, MD
New York University	Brooklyn	New York	11220	Aaron Lord Aaron Lord (PRINCIPAL_INVESTIGATOR)
Columbia University	New York	New York	10032	Joshua Wiley, MD Joshua Wiley, MD (PRINCIPAL_INVESTIGATOR)
Icahn School of Medicine at Mount Sinai	New York	New York	10029	Shahram Majidi, MD Shahram Majidi, MD (PRINCIPAL_INVESTIGATOR)
University of Cincinnati Medical Center	Cincinnati	Ohio	45219	Stacie Demel, DO, PhD Stacie Demel, DO, PhD (PRINCIPAL_INVESTIGATOR)
Providence St. Vincent Medical Center	Portland	Oregon	97225	Amit Kansara, MD Amit Kansara, MD (PRINCIPAL_INVESTIGATOR)
University of Pittsburgh Medical Center	Pittsburgh	Pennsylvania	15213	Raul Nogueira, MD Raul Nogueira, MD (PRINCIPAL_INVESTIGATOR)
Baptist Memorial Hospital	Memphis	Tennessee	38120	Violiza Inoa, MD Violiza Inoa, MD (PRINCIPAL_INVESTIGATOR)
Vanderbilt University Medical Center	Nashville	Tennessee	37232	Deborah Kerrigan, MD Deborah Kerrigan, MD (PRINCIPAL_INVESTIGATOR)
University of Texas at Austin	Austin	Texas	78712	Hamidreza Saber, MD Hamidreza Saber, MD (PRINCIPAL_INVESTIGATOR)
University of Washington	Seattle	Washington	98104	David Tirschwell, MD David Tirschwell, MD (PRINCIPAL_INVESTIGATOR)
West Virginia University	Morgantown	West Virginia	26506	Ansaar Rai, MD Ansaar Rai, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Phoenix, AZ

By condition

Stroke

By specialty

Neurology Brain disorders

By research site

HonorHealth· Phoenix, AZ Kaiser Permanente Los Angeles Medical Center· Los Angeles, CA University of California at Los Angeles· Los Angeles, CA Standford· Palo Alto, CA University of Cincinnati San Diego· San Diego, CA Swedish Medical Center· Englewood, CO

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