Effectiveness of Cognitive Training in Older and Younger Adults

Part of paid clinical trials in Riverside, California.

Sponsor
University of Wisconsin, Madison
Study ID
NCT06375681
Status
Recruiting
Apply to this trial

Conditions

  • Cognitive Change

Eligibility Criteria

Sex
ALL
Age
18 Years - 85 Years
Healthy Volunteers
Accepted

Interventions

  • Visual and / or Auditory Cognitive Tasks (1) — BEHAVIORAL
    Seven sessions (\~45-75 minutes) of cognitive tasks in the lab. Participants asked to view visual stimuli (such as black and white lines, letters, simple shapes like triangles, circles, and squares) presented on a computer or television screen and/or listen to auditory stimuli (such as pure tones) presented via headphone or speakers and asked to make simple judgements.
  • Visual and / or Auditory Cognitive Tasks (2) — BEHAVIORAL
    Two sets of 10 sessions (\~20 minutes) of cognitive tasks either at home or in the lab. Participants asked to view visual stimuli (such as black and white lines, letters, simple shapes like triangles, circles, and squares) presented on a computer or television screen and/or listen to auditory stimuli (such as pure tones) presented via headphone or speakers and asked to make simple judgements.

Study Details

The proposed study will enroll 1600 participants to examine the effectiveness of cognitive training. Participants will be randomized into different experimental groups and can expect to participate for up to 15 hours of research over 4 to 8 weeks.

Key Dates

Start date
Apr 1, 2025
Status verified
Apr 2026
Primary completion
May 31, 2027
Completion
Jul 31, 2027

Study Design

Enrollment
1,600 participants (estimated)
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
BASIC_SCIENCE

Arms

  • Active Comparator: Short Testing Group
    Participants will go through 2 assessment sessions over 2-3 days (\~75 minutes each), followed by 1 session of 75 minutes about 2 weeks later, 2 further sessions (\~75 minutes) over 2-3 days about 2 weeks after this session, and finally another 2 sessions (\~45 minutes) 3 days to 2 weeks after that session. Sessions might take place either at home or in the lab.
  • Active Comparator: Long Testing Group
    Participants will go through 2 assessment sessions over 2-3 days (75 minutes each), followed by 10 sessions of cognitive tasks over 2 weeks, 1 session of 75 minutes about 2 weeks later, another 10 sessions of cognitive tasks over 2 weeks, then 2 sessions (\~75 minutes) over 2-3 days about 2 weeks after this session, and finally another 2 sessions (\~45 minutes) 3 days to 2 weeks after that session. Sessions might take place either at home or in the lab.

Primary Outcome Measure

Change in the difference between the proportion of hits minus false alarms for a given level of the N-back task [ Time Frame: Pre-test (baseline), post-test1 up to 30 days, (unmasked) post-test2 up to 60 days ]

Central Contacts

Locations (3)

FacilityCityStateZIPSite coordinators
University of California, RiversideRiversideCalifornia92521
Aaron Seitz, PhD
[email protected]
951-827-6422
Northeastern UniversityBostonMassachusetts02115
Susanne Jaeggi, PhD
[email protected]
617-373-3653
University of Wisconsin - MadisonMadisonWisconsin53706
C. Shawn Green, PhD
[email protected]
608-263-4868

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By research site
University of California, Riverside· Riverside, CANortheastern University· Boston, MAUniversity of Wisconsin - Madison· Madison, WI

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