Interventions in Mathematics and Cognitive Skills

Part of paid clinical trials in Palo Alto, California.

Sponsor
Stanford University
Study ID
NCT05201534
Status
Recruiting
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Conditions

  • Behavior
  • Behavior and Behavior Mechanisms
  • Behavior, Child
  • Child Development
  • Cognition
  • Cognition Disorder
  • Cognitive Abnormality
  • Cognitive Change
  • Cognitive Deficits, Mild
  • Cognitive Delay, Mild
  • Cognitive Developmental Delay
  • Cognitive Dysfunction
  • Cognitive Impairment, Mild
  • Cognitive Orientation
  • Decision Making
  • Developmental Disability
  • Dyscalculia
  • Dyscalculia, Acquired
  • Dyscalculia, Primary
  • Individuality
  • Learning Curve
  • Learning Disabilities
  • Learning Disabled
  • Math Learning Disability
  • Mathematics Disorder
  • Neuronal Plasticity
  • Neuroscience
  • Specific Learning Disorder, With Impairment in Mathematics

Eligibility Criteria

Sex
ALL
Age
6 Years - 12 Years
Healthy Volunteers
Accepted

Interventions

  • Interventions in Mathematics and Cognitive Skills - Experimental — OTHER
    After study participants have completed screenings to meet our inclusion criteria, participants will take part in the pre-training MRI brain scan (if eligible) and behavioral assessments and will then be assigned to the intervention for 6 weeks. During this training, participants will spend three days each week completing a set of problems at their home on a tablet that we provide them. Participants will receive one-to-one training with a member of our research team once a week. Following the completion of the 6-week training program, participants will be asked to complete a second MRI brain imaging session (for those who completed pre-training MRI) and post-measure appointments in order to assess immediate effects of the training program. Participants will also be invited to return for follow-up testing after six months in order to assess the long- lasting effects of the training program.
  • Interventions in Mathematics and Cognitive Skills - Active Comparator — OTHER
    After study participants have completed screenings to meet our inclusion criteria, participants will take part in the pre-training MRI brain scan (if eligible) and behavioral assessments and will then be assigned to the intervention for 6 weeks. During this training, participants will spend three days each week completing a set of problems at their home on a tablet that we provide them. Participants will receive one-to-one training with a member of our research team once a week. Following the completion of the 6-week training program, participants will be asked to complete a second MRI brain imaging session (for those who completed pre-training MRI) and post-measure appointments in order to assess immediate effects of the training program. Participants will also be invited to return for follow-up testing after six months in order to assess the long- lasting effects of the training program.

Study Details

The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning disabilities (MLD).

Key Dates

Start date
May 5, 2023
Status verified
Aug 2025
Primary completion
Jun 30, 2026
Completion
Jun 30, 2026

Study Design

Enrollment
180 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Integrative Symbolic Non-Symbolic (iSNS) Training
    Integrative symbolic non-symbolic (iSNS) training: Over a period of 6 weeks, participants will complete activities that progressively strengthen the mapping of symbolic numerical representations to non-symbolic numerical quantities and enhance fluency in symbolic numerical skills.
  • Active Comparator: Active Comparator: Active Control Intervention (Working Memory Training)
    Active control intervention: Over a period of 6 weeks, participants will complete activities that enhance short-term storage and maintenance of visuospatial or verbal information.

Primary Outcome Measure

Change from baseline in symbolic number comparison task performance (reaction time) [ Time Frame: Baseline and post-intervention (after 6 weeks) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Stanford Cognitive and Systems Neuroscience LaboratoryPalo AltoCalifornia94304
Zehra Unal
[email protected]
737-615-0834
Oliver Lasnick
[email protected]
818-836-7956
Vinod Menon, Ph.D. (PRINCIPAL_INVESTIGATOR)
Yunji Park, Ph.D. (SUB_INVESTIGATOR)

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By research site
Stanford Cognitive and Systems Neuroscience Laboratory· Palo Alto, CA

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