TMS for Cognitive Decline in Aging and Preclinical AD

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Massachusetts General Hospital
Study ID
NCT06956300
Status
Recruiting
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Conditions

  • Cognitive Decline
  • Healthy Aging
  • Preclinical Alzheimer's Disease
  • Prodromal Alzheimer's Disease

Eligibility Criteria

Sex
ALL
Age
40 Years - 99 Years
Healthy Volunteers
Accepted

Interventions

  • Active rTMS — DEVICE
    All study participants will receive one block of ACTIVE rTMS. Each block will consist of daily sessions of active rTMS delivered to the left dorsolateral prefrontal cortex over ten days (Monday through Friday).
  • Sham rTMS — DEVICE
    All study participants will receive one block of SHAM rTMS. Each block will consist of daily sessions of SHAM rTMS delivered to the left dorsolateral prefrontal cortex over ten days (Monday through Friday).

Study Details

In this research study we want to learn more about the effects of non-invasive brain stimulation on motivation, memory, and brain-network function in cognitively unimpaired older adults and individuals with preclinical Alzheimer's disease. This study will use a form of non-invasive brain stimulation called repetitive Transcranial Magnetic Stimulation (rTMS). rTMS will slightly alter activity in an area of your brain that controls cognition. Changes resulting from this stimulation will be measured with behavioral tests, as well as by taking brain images with Magnetic Resonance Imaging (MRI). Participants will come in for one baseline visit followed by 10 days of daily rTMS study visits (Monday through Friday) and an evaluation visit. Then, there will be a 2-week break. After this break, they will return for another baseline visit, an additional 10 days of rTMS, and a final evaluation visit.

Key Dates

Start date
Apr 7, 2025
Status verified
Feb 2026
Primary completion
Aug 31, 2029
Completion
Aug 31, 2029

Study Design

Enrollment
80 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER

Arms

  • Experimental: Active TMS
    All participants will receive the same study interventions in a within-subject crossover design.
  • Sham Comparator: Sham TMS
    All participants will receive the same study interventions in a within-subject crossover design.

Primary Outcome Measure

Changes in motivation [ Time Frame: Baseline and post-treatment Day 11 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Massachusetts General HospitalBostonMassachusetts02129
Alexandra Touroutoglou, MSc, PhD
[email protected]
617-643-6348
Alexandra Touroutoglou, MSc, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
Massachusetts General Hospital· Boston, MA

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