Paid Clinical Trials in South Dakota

South Dakota has 341 paid clinical trials enrolling now across cities including Sioux Falls, Rapid City and Pierre. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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341 clinical trials

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Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

for Breast Carcinoma

464 locations incl. Fairbanks

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06418204·Recruiting

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A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)

for Diffuse Large B-Cell Lymphoma

Drug: Rituximab

42 locations incl. Gilbert

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06717347·Phase 3·Recruiting

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SUPRAME-ACTengine® IMA203 vs. Investigator's Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma

for Melanoma, Cutaneous Malignant

40 locations incl. Phoenix

Sponsor: Immatics US, Inc.

Sex: All·Age: 18+

Code: NCT06743126·Phase 3·Recruiting

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A Study of Vedolizumab With and Without Upadacitinib in Adults With Crohn's Disease

for Crohn's Disease

Drug: Upadacitinib

19 locations incl. La Jolla

Sponsor: Takeda

Sex: All·Age: 18 - 65

Code: NCT06227910·Phase 3·Recruiting

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Mindfulness-Based Interventions Targeting First-Generation College Student Retention in Rural Environments

for Depression

1 location in Sioux Falls

Sponsor: University of South Dakota

Sex: All·Age: 18 - 64·Accepts healthy volunteers

Code: NCT06789731·Recruiting

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A Study of ASP-1929 Photoimmunotherapy in Combination With Pembrolizumab in First-line Treatment of Locoregional Recurrent Squamous Cell Carcinoma of the Head and Neck With No Distant Metastases

for Recurrent Head and Neck Squamous Cell Carcinoma

8 locations incl. Duarte

Sponsor: Rakuten Medical, Inc.

Sex: All·Age: 18+

Code: NCT06699212·Phase 3·Recruiting

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Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

for Heart Failure

88 locations incl. Alexander City

Sponsor: Cytokinetics

Sex: All·Age: 18 - 85

Code: NCT06736574·Phase 3·Recruiting

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A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

for Carcinoma, Non-Small-Cell Lung

Drug: Amivantamab

150 locations incl. Daphne

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT06667076·Phase 2·Recruiting

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Sapanisertib and Serabelisib (PIKTOR) With Paclitaxel and a Substudy With an Insulin-Suppressing Diet in Patients With Advanced/Recurrent Endometrial Cancer

for Endometrial Cancer

18 locations incl. La Jolla

Sponsor: Faeth Therapeutics

Sex: Female·Age: 18+

Code: NCT06463028·Phase 2·Recruiting

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Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

for Anatomic Stage IV Breast Cancer AJCC v8

256 locations incl. Tucson

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT06500455·Phase 3·Recruiting

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Comparing Impact of Treatment Before or After Surgery in Patients With Stage II-IIIB Resectable Non-small Cell Lung Cancer

for Resectable Lung Non-Small Cell Carcinoma

378 locations incl. Birmingham

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT06632327·Phase 3·Recruiting

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A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Metastatic Non-squamous NSCLC

for Non-squamous Non-small Cell Lung Cancer

Drug: Rilvegostomig

77 locations incl. Mobile

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06627647·Phase 3·Recruiting

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Measuring Outcomes of LASIK and EVO-ICL in Matched Populations

for Myopia

5 locations incl. Omaha

Sponsor: Vance Thompson Vision

Sex: All·Age: 21 - 45

Code: NCT06700460·Recruiting

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A Study to Evaluate Vimseltinib in Adults With Active Chronic Graft-Versus-Host Disease (cGVHD)

for Chronic Graft-Versus-Host Disease (cGVHD)

26 locations incl. Duarte

Sponsor: Deciphera Pharmaceuticals, LLC

Sex: All·Age: 18+

Code: NCT06619561·Phase 2·Recruiting

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Trial of the Impact of Sibeprenlimab on Immunoglobulin A Nephropathy Kidney Tissue

for IgA Nephropathy

4 locations incl. Denver

Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.

Sex: All·Age: 16+

Code: NCT06740526·Phase 2·Recruiting

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A Study of Cemiplimab Plus Chemotherapy Versus Cemiplimab Plus Chemotherapy Plus Other Cancer Treatments for Adult Patients With Operable Non-Small Cell Lung Cancer (NSCLC)

for Non-Small Cell Lung Cancer

Drug: Cemiplimab

14 locations incl. Orange

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06465329·Phase 2·Recruiting

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Prevalence of Antibodies and Cytokines in Participants With Chronic Granulomatous Disease

for Chronic Granulomatous Disease (CGD)

50 locations incl. Montgomery

Sponsor: Ensoma

Sex: All·Age: All ages

Code: NCT06605378·Recruiting

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A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Metastatic Squamous Non-small Cell Lung Cancer (NSCLC)

for Non-small Cell Lung Cancer

Drug: Rilvegostomig

74 locations incl. Tucson

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06692738·Phase 3·Recruiting

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A Study to Learn About the Study Medicine Called Rimegepant in Adolescents With Frequent Migraine

for Migraine

Drug: Rimegepant

27 locations incl. Phoenix

Sponsor: Pfizer

Sex: All·Age: 12 - 17

Code: NCT06616194·Phase 3·Recruiting

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Efficacy and Safety of Obefazimod in Subjects With Moderately to Severely Active Crohn's Disease

for Moderately to Severely Active Crohn Disease

43 locations incl. Fairhope

Sponsor: Abivax S.A.

Sex: All·Age: 18 - 75

Code: NCT06456593·Phase 2·Recruiting

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A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy

for Age-related Macular Degeneration (AMD)

Drug: Cemdisiran

152 locations incl. Chandler

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 50 - 85

Code: NCT06541704·Phase 3·Recruiting

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A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Endometrial Cancer.

for Endometrial Cancer

Drug: Lifileucel

12 locations incl. Phoenix

Sponsor: Iovance Biotherapeutics, Inc.

Sex: Female·Age: 18 - 70

Code: NCT06481592·Phase 2·Recruiting

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Phase 2 Study Evaluating Rapcabtagene Autoleucel in Participants With Diffuse Cutaneous Systemic Sclerosis

for Scleroderma, Diffuse

14 locations incl. Los Angeles

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 70

Code: NCT06655896·Phase 2·Recruiting

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A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma

for Basal Ganglia Germinoma

92 locations incl. Mobile

Sponsor: Children's Oncology Group

Sex: All·Age: 3 - 29

Code: NCT06368817·Phase 2·Recruiting

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Subcutaneous Tarlatamab in Participants With Extensive Stage Small Cell Lung Cancer (DeLLphi-308)

for Extensive Stage Small Cell Lung Cancer

Drug: Tarlatamab

6 locations incl. Los Angeles

Sponsor: Amgen

Sex: All·Age: 18+

Code: NCT06598306·Phase 1·Recruiting

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A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence

for Breast Cancer

165 locations incl. Daphne

Sponsor: Stemline Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06492616·Phase 3·Recruiting

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Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas

for Metastatic Dedifferentiated Liposarcoma

245 locations incl. Phoenix

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06422806·Phase 3·Recruiting

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Study of Targeted Therapy vs. Chemotherapy in Patients With Thyroid Cancer

for Refractory Differentiated Thyroid Gland Carcinoma

301 locations incl. Anchorage

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT06475989·Phase 3·Recruiting

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Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)

for B-cell Acute Lymphoblastic Leukemia

17 locations incl. Los Angeles

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 6 Months - 25

Code: NCT06395103·Phase 1, Phase 2·Recruiting

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Exercise-induced Hypoalgesia and Proprioceptive Changes, Comparing Isometric to Isotonic Neck Exercises

for Exercise

1 location in Vermillion

Sponsor: University of South Dakota

Sex: All·Age: 18 - 64·Accepts healthy volunteers

Code: NCT06465394·Recruiting

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Melodi Matrix™ in Breast Reconstruction

for Breast Reconstruction

10 locations incl. Palo Alto

Sponsor: Melodi Health, Inc.

Sex: Female·Age: 22+

Code: NCT06027996·Recruiting

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Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

for Recurrent Lung Non-Small Cell Carcinoma

266 locations incl. Daphne

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18 Minutes+

Code: NCT06031688·Phase 2·Recruiting

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Smoking Cessation Intervention for American Indian Women Experiencing Intimate Partner Violence

for Smoking Cessation

1 location in Rapid City

Sponsor: Black Hills Center for American Indian Health

Sex: Female·Age: 18+

Code: NCT06357767·Recruiting

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A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)

for Head and Neck Squamous Cell Carcinoma

29 locations incl. Duarte

Sponsor: Tempus AI

Sex: All·Age: 18+

Code: NCT06163534·Recruiting

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Investigations of Reproductive Cancers in Women

for Uterine Cancer

16 locations incl. Birmingham

Sponsor: PinkDx, Inc.

Sex: Female·Age: 45 - 100

Code: NCT06527157·Recruiting

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Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial

for Advanced Lung Non-Small Cell Carcinoma

318 locations incl. Fayetteville

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 70+

Code: NCT06096844·Phase 3·Recruiting

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Study of Acalabrutinib and Rituximab in Untreated Elderly and/or Frail Patients With DLBCL

for Diffuse Large B-Cell Lymphoma

Drug: Rituximab

14 locations incl. Berkeley

Sponsor: AstraZeneca

Sex: All·Age: 65 - 99

Code: NCT05952024·Phase 2·Recruiting

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Study of WAL0921 in Patients With Glomerular Kidney Diseases

for Diabetic Nephropathies

9 locations incl. Los Angeles

Sponsor: Walden Biosciences

Sex: All·Age: 18 - 75

Code: NCT06466135·Phase 2·Recruiting

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Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer

for Rectal Cancer

101 locations incl. Phoenix

Sponsor: Canadian Cancer Trials Group

Sex: All·Age: 18+

Code: NCT06205485·Phase 3·Recruiting

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A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)

for Stage II Nasopharyngeal Carcinoma AJCC v8

Drug: Nivolumab

76 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: Up to 21

Code: NCT06064097·Phase 2·Recruiting

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