A Study to Evaluate Vimseltinib in Adults With Active Chronic Graft-Versus-Host Disease (cGVHD)

Part of paid clinical trials in Duarte, California.

Sponsor
Deciphera Pharmaceuticals, LLC
Study ID
NCT06619561
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

  • Chronic Graft-Versus-Host Disease (cGVHD)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Vimseltinib — DRUG
    Administered orally

Study Details

The purpose of this study is to determine if vimseltinib is safe, tolerable and works effectively to treat adults with active moderate to severe cGVHD. Participants will be treated with vimseltinib in 28-day treatment cycles for approximately 2 years.

Key Dates

Start date
Nov 21, 2024
Status verified
Dec 2025
Primary completion
Oct 31, 2029
Completion
Oct 31, 2029

Study Design

Enrollment
48 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Vimseltinib
    Escalating doses of vimseltinib in 28 day cycles.

Primary Outcome Measure

Number of Participants with Dose-Limiting Toxicities (DLTs) [ Time Frame: Cycle 1 (28 Days) ]

Central Contacts

Locations (26)

FacilityCityStateZIPSite coordinators
City of Hope National Medical CenterDuarteCalifornia91010-
Ronald Regan UCLA Medical CenterLos AngelesCalifornia90095-
University of California Irvine HealthOrangeCalifornia92868-3201-
AdventHealth OrlandoOrlandoFlorida32804-
Moffitt Cancer CenterTampaFlorida33612-
Emory University Winship Cancer InstituteAtlantaGeorgia30322-
University of Illinois Medical Center - Hematology & OncologyChicagoIllinois60612-
University of Kansas Cancer Center-WestwoodWestwoodKansas66205-
University of Kentucky Markey Cancer CenterLexingtonKentucky40536-
Dana-Farber Cancer InstituteBostonMassachusetts02215-
Henry Ford Cancer InstituteDetroitMichigan48202-
Washington University School of Medicine - Siteman Cancer CenterSt LouisMissouri63108-
Levine Cancer InstituteCharlotteNorth Carolina28204-
Duke University HospitalDurhamNorth Carolina27705-
Oncology Hematology Care Clinical Trials, LLCCincinnatiOhio45242-
Cleveland ClinicClevelandOhio44195-
The Ohio State University Comprehensive Cancer CenterColumbusOhio43210-
Oregon Health and Science UniversityPortlandOregon97239-
UPMC Hillman Cancer CenterPittsburghPennsylvania15232-
Avera Cancer InstituteSioux FallsSouth Dakota57105-
Tristar Bone Marrow TransplantNashvilleTennessee37203-
Vanderbilt-Ingram Cancer CenterNashvilleTennessee37232-
St. David's South Austin Medical CenterAustinTexas78704-
UT Southwestern Medical CenterDallasTexas75390-
Intermountain HealthSalt Lake CityUtah84143-
Virginia Commonwealth UniversityRichmondVirginia23298-

Find similar trials in Duarte, CA

By research site
City of Hope National Medical Center· Duarte, CARonald Regan UCLA Medical Center· Los Angeles, CAUniversity of California Irvine Health· Orange, CAAdventHealth Orlando· Orlando, FLMoffitt Cancer Center· Tampa, FLEmory University Winship Cancer Institute· Atlanta, GA

Related Studies