A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Endometrial Cancer.

Part of paid clinical trials in Phoenix, Arizona.

Sponsor
Iovance Biotherapeutics, Inc.
Study ID
NCT06481592
Phase
PHASE2
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 70 Years
Healthy Volunteers
Not accepted

Interventions

  • Lifileucel — BIOLOGICAL
    A tumor sample is resected from each patient and cultured ex vivo to expand the population of tumor infiltrating lymphocytes. After lymphodepleting chemotherapy including cyclophosphamide and fludarabine, participant is infused with lifileucel, followed by IL-2.

Study Details

The purpose of this study is to investigate the efficacy and safety of the lifileucel regimen in participants with previously treated endometrial cancer.

Key Dates

Start date
Oct 29, 2024
Status verified
Oct 2025
Primary completion
May 31, 2028
Completion
Nov 30, 2029

Study Design

Enrollment
60 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Patients with Endometrial Cancer

Primary Outcome Measure

Objective Response Rate [ Time Frame: Up to 5 Years ]

Central Contacts

Locations (12)

FacilityCityStateZIPSite coordinators
Honor HealthPhoenixArizona85016-
University of Southern CaliforniaLos AngelesCalifornia90007-
Orlando HealthOrlandoFlorida32806-
H. Lee Moffitt Cancer Center and Research Institute, Inc.TampaFlorida33612-
Augusta UniversityAugustaGeorgia30912-
UofL Health - Brown Cancer CenterLouisvilleKentucky40202-
Barbara Ann Karmanos Cancer HospitalDetroitMichigan48201-
Roswell Park Cancer InstituteBuffaloNew York14203-
University of OklahomaOklahoma CityOklahoma73117-
Allegheny HealthPittsburghPennsylvania15524-
Avera Medical Group OncologySioux FallsSouth Dakota57105-
MD Anderson Cancer Center - U of TexasHoustonTexas77030-

Find similar trials in Phoenix, AZ

By condition
Endometrial cancer
By specialty
OncologyGynecologic oncologyWomen's health
By research site
Honor Health· Phoenix, AZUniversity of Southern California· Los Angeles, CAOrlando Health· Orlando, FLH. Lee Moffitt Cancer Center and Research Institute, Inc.· Tampa, FLAugusta University· Augusta, GAUofL Health - Brown Cancer Center· Louisville, KY

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