Clinical Trials at Mayo Clinic

As of June 2026, 491 paid clinical trials are recruiting at Mayo Clinic, located at 5360 KINGSBURY PL NW, ROCHESTER, MN 55901-2192, phone (507) 284-2511 in Rochester, Minnesota. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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491 clinical trials at Mayo Clinic

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JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort B: Paridiprubart

for Acute Respiratory Distress Syndrome (ARDS)

Drug: Cohort B: paridiprubart

40 locations incl. Birmingham

Sponsor: PPD Development, LP

Sex: All·Age: 18+

Code: NCT06701669·Phase 2·Recruiting

Apply to this trial

JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS (Master Record)

for Acute Respiratory Distress Syndrome (ARDS)

40 locations incl. Birmingham

Sponsor: PPD Development, LP

Sex: All·Age: 18+

Code: NCT06703073·Phase 2·Recruiting

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SLIT ABS: Study on Patients With Autoimmune Podocytopathy

for Nephrotic Syndrome With Edema (Diagnosis)

1 location in Rochester

Sponsor: Meyer Children's Hospital IRCCS

Sex: All·Age: 0 - 99

Code: NCT07516964·Recruiting

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A Double-blind Study Evaluating the Efficacy, Safety, and Tolerability of Zorevunersen in Patients With Dravet Syndrome

for Dravet Syndrome

Drug: zorevunersen

31 locations incl. Phoenix

Sponsor: Stoke Therapeutics, Inc

Sex: All·Age: 2 - 17

Code: NCT06872125·Phase 3·Recruiting

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Radio- KO Radiotherapy for Knee Osteoarthritis Clinical Trial

for Osteoarthritis, Knee

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 50 - 85

Code: NCT06887829·Recruiting

Apply to this trial

Prevention of Ototoxicity in NTM Patients Treated With IV Amikacin

for Ototoxicity, Drug-Induced

7 locations incl. San Francisco

Sponsor: Kevin Winthrop

Sex: All·Age: 18 - 80

Code: NCT05730283·Phase 2·Recruiting

Apply to this trial

Pioglitazone Versus Empagliflozin for Chronic Pancreatitis/Recurrent Acute Pancreatitis Associated Diabetes Mellitus

for Pancreatitis, Chronic

Drug: Empagliflozin

2 locations incl. Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 80

Code: NCT06729996·Phase 2·Recruiting

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JAB-23E73 in Adult Participants With Advanced Solid Tumors With KRAS Alteration

for Advanced Solid Tumors

4 locations incl. Rochester

Sponsor: Jacobio Pharmaceuticals Co., Ltd.

Sex: All·Age: 18+

Code: NCT06973564·Phase 1, Phase 2·Recruiting

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Study of BLU-808 in Chronic Inducible Urticaria (CIndU) and Chronic Spontaneous Urticaria (CSU)

for Chronic Inducible Urticaria

27 locations incl. Birmingham

Sponsor: Blueprint Medicines Corporation

Sex: All·Age: 18+

Code: NCT06931405·Phase 2·Recruiting

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A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression

for Solid Tumor, Adult

10 locations incl. Gilbert

Sponsor: A2 Biotherapeutics Inc.

Sex: All·Age: 18+

Code: NCT06682793·Phase 1, Phase 2·Recruiting

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A Study to Assess the Safety and Effectiveness of the UrOActive® Artificial Urinary sPHincter (AUS)

for Stress Urinary Incontinence (SUI)

13 locations incl. Los Angeles

Sponsor: UroMems SAS

Sex: Male·Age: 22+

Code: NCT06968741·Recruiting

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CAMEO-FONTAN -Dapagliflozin in the Failing Fontan Circulation

for Fontan Circulation

Drug: Dapagliflozin

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06762964·Phase 2·Recruiting

Apply to this trial

HTN App for HTN Control and Cardiovascular Health Among African-Americans

for Hypertension

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06346886·Recruiting

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Comparing The Safety And Efficacy Of DEFENCATH® In Reducing Central-Line Bloodstream Infections (CLABSIs) In Adults Receiving Total Parenteral Nutrition Through A Central Venous Catheter (CVC)

for Central Line Associated Blood Stream Infections (CLABSI)

17 locations incl. Los Angeles

Sponsor: CorMedix

Sex: All·Age: 18+

Code: NCT06822426·Phase 3·Recruiting

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MAGIC Ruxolitinib for aGVHD

for Acute Graft-versus-host Disease

Drug: Ruxolitinib

14 locations incl. Duarte

Sponsor: John Levine

Sex: All·Age: 18+

Code: NCT06936566·Phase 2·Recruiting

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Clinical Trial of Upfront Haploidentical or Unrelated Donor BMT to Restore Normal Hematopoiesis in Aplastic Anemia

for Severe Aplastic Anemia

25 locations incl. Birmingham

Sponsor: Medical College of Wisconsin

Sex: All·Age: 3 - 75

Code: NCT06517641·Phase 2·Recruiting

Apply to this trial

A Randomized Controlled Trial of Menopausal Tool/App for Women

for Menopausal Symptoms

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 24 - 80

Code: NCT06919887·Enrolling By Invitation

Safety of HRX215 in Patients After Minor and Major Liver Resection

for Liver Resection

1 location in Rochester

Sponsor: HepaRegeniX GmbH

Sex: All·Age: 18 - 75

Code: NCT06638502·Phase 1, Phase 2·Recruiting

Apply to this trial

A Phase 1 Study of Anitocabtagene Autoleucel for the Treatment of Subjects With Non-oncology Plasma Cell-related Diseases

for Muscular Diseases

13 locations incl. Los Angeles

Sponsor: Arcellx, Inc.

Sex: All·Age: 18+

Code: NCT06626919·Phase 1·Recruiting

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BRAZAN: A Randomized Phase 2 Study of Bendamustine, Rituximab, Cytarabine (AraC) Induction With Zanubrutinib (BRAZAN) Followed by Zanubrutinib/Rituximab +/- Sonrotoclax Maintenance in Treatment-Naïve Mantle Cell Lymphoma

for Mantle Cell Lymphoma

Drug: Sonrotoclax

7 locations incl. Phoenix

Sponsor: Christine Ryan

Sex: All·Age: 18+

Code: NCT06854003·Phase 2·Recruiting

Apply to this trial

Breastmilk in Response to a Bout of Exercise

for Infant Development

1 location in Rochester

Sponsor: Mayo Clinic

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT06892483·Recruiting

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Evaluation of Plasma Renin Concentrations in Cardiac Surgery

for Cardiac Surgery With Cardiopulmonary Bypass

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06895213·Recruiting

Apply to this trial

CardiolRx in Recurrent Pericarditis (MAVERIC Phase-3)

for Recurrent Pericarditis

21 locations incl. Phoenix

Sponsor: Cardiol Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06708299·Phase 3·Recruiting

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Autologous Bone Marrow Aspirate Treatment for Early-Stage Osteonecrosis

for Osteonecrosis of the Femoral Head

10 locations incl. Los Angeles

Sponsor: Johns Hopkins University

Sex: All·Age: 18 - 90

Code: NCT06123481·Recruiting

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The Dragon PLC Trial (DRAGON-PLC)

for Primary Liver Cancer

5 locations incl. New Haven

Sponsor: Maastricht University

Sex: All·Age: 18+

Code: NCT06914648·Recruiting

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Enabling Microbiomics- Driven Personalized Nutrition

for Inflammatory Bowel Disease (IBD)

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06657001·Enrolling By Invitation

Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study

for Major Depressive Disorder

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06897670·Recruiting

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Ultra-High Frequency - Electrocardiogram (UHF-ECG) for the Diagnosis of Ventricular Electrical Dyssynchrony (VED)

for Bradycardia

7 locations incl. Avondale

Sponsor: VDI Technologies

Sex: All·Age: 18+

Code: NCT06641362·Recruiting

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A Phase 1 Study of STX-0712 in Patients With Advanced Hematological Malignancies (CMML and AML)

for Chronic Myelomonocytic Leukemia

7 locations incl. Stanford

Sponsor: Solu Therapeutics, Inc

Sex: All·Age: 18+

Code: NCT06950034·Phase 1·Recruiting

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A Phase 2 Study of YA-101 in Patients With Multiple System Atrophy

for Multiple System Atrophy

6 locations incl. Los Angeles

Sponsor: Dasher Neuroscience Inc.

Sex: All·Age: 30+

Code: NCT06848231·Phase 2·Recruiting

Apply to this trial

A Comparison of Neuromuscular Recruitment in Trained and Untrained Adults

for Healthy

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 60 - 85·Accepts healthy volunteers

Code: NCT06820658·Recruiting

Apply to this trial

Treatment of Upper Gastrointestinal Symptoms Using Hypnotherapy Sessions

for GI Symptoms

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06846359·Recruiting

Apply to this trial

The PeriCut Catheter System Early Feasibility Study (REIMAGINE-HFpEF)

for Heart Failure With Preserved Ejection Fraction

1 location in Rochester

Sponsor: Heart Failure Solutions, Inc.

Sex: All·Age: 30+

Code: NCT06702501·Recruiting

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A Study of Hemodynamic Cardiopulmonary Exercise for CHD

for Congenital Heart Disease

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06566196·Recruiting

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Assessment of Risks of Perinephric Fat Thickness to Adverse Renal Outcomes Post Donor Nephrectomy

for Living Kidney Donation

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT06886087·Recruiting

Apply to this trial

REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE

for Aortic Stenosis

71 locations incl. Birmingham

Sponsor: Medtronic Cardiovascular

Sex: All·Age: 18 - 105

Code: NCT06777368·Recruiting

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AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEF

for Symptomatic Heart Failure With Preserved Ejection Fraction (HFpEF)

25 locations incl. Fairhope

Sponsor: Cytokinetics

Sex: All·Age: 40 - 85

Code: NCT06793371·Phase 2·Recruiting

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Zunsemetinib in Combination With Capecitabine in Patients With Hormone Receptor-Positive and HER2-Negative Metastatic Breast Cancer With Bone Metastasis

for Hormone Receptor Positive HER-2 Negative Metastatic Breast Cancer

3 locations incl. Westwood

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT06374459·Phase 1, Phase 2·Recruiting

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Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

for Breast Carcinoma

464 locations incl. Fairbanks

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06418204·Recruiting

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Phenotype-Tailored Lifestyle Intervention for Obesity: A Randomized Trial

for Obesity

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 65

Code: NCT06770049·Recruiting

Apply to this trial