Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study

Conditions

• Bipolar Disorder
• Major Depressive Disorder
• Mild Cognitive Impairment

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Observational assessment using functional near-infrared spectroscopy (fNIRS), a noninvasive, portable brain imaging tool that measures changes in brain blood flow and oxygen levels. — OTHER
  Functional near-infrared spectroscopy (fNIRS) transcutaneously measures changes in oxyhemoglobin in the prefrontal cortex using light detection. It is designed to measure variations in cerebral hemodynamics on a real-time basis by radiating a near light beam, at two wavelengths of 780nm and 850nm of laser, into the cerebral cortex. Participants will undergo a one-time functional near-infrared spectroscopy (fNIRS) procedure to measure cerebral hemodynamic patterns. * Resting-State Measurement: 5-10 min resting-state scans. * Task-Based Measurement: Participants will be shown an instruction video. Participants will complete a Verbal Fluency Task (VFT) during the fNIRS scan (15-20 min). * During the fNIRS scan, optional basic vital signs will be measured using respiratory belts, photoplethysmography (PPG), and electrocardiogram (ECG). * Each participant will complete 3 sets of resting-state and task-based measurements. Total estimated time for fNIRS assessment: 45-60 min.

Study Details

The purpose of this research is to measure brain activity in individuals with mood disorders and memory problems using a simple, safe, and noninvasive method called functional near-infrared spectroscopy (fNIRS). By comparing brain activity across different groups and relating it to symptom severity, this study aims to improve our understanding of how these conditions affect the brain.

Key Dates

Start date

Mar 26, 2025

Status verified

Apr 2026

Primary completion

Mar 30, 2028

Completion

Mar 30, 2028

Study Design

Enrollment

200 participants (estimated)

Arms

• Arm: Healthy Controls
  o No past or current psychiatric or cognitive disorder.
• Arm: Major Depressive Disorder
  * Diagnosis of major depressive disorder, confirmed through clinical evaluation. * No history of bipolar disorder or psychotic symptoms.
• Arm: Bipolar Disorder
  o Diagnosis of bipolar disorder I or II, confirmed through clinical evaluation.
• Arm: Mild Cognitive Impairment (MCI)
  * Pre-existing clinical diagnosis of mild cognitive impairment, supported by neuropsychological testing and/or MRI, PET scan data. * No history of major psychiatric disorders, such as major depression, bipolar disorder or schizophrenia.

Primary Outcome Measure

Changes in oxyhemoglobin [ Time Frame: Baseline, 60 minutes ]

Central Contacts

• Sarah M. Williams
  507-422-2972
  [email protected]

Locations (1)

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