JAB-23E73 in Adult Participants With Advanced Solid Tumors With KRAS Alteration

Part of paid clinical trials in Rochester, Minnesota.

Sponsor
Jacobio Pharmaceuticals Co., Ltd.
Study ID
NCT06973564
Phase
PHASE1/PHASE2
Status
Recruiting
Apply to this trial

Conditions

  • Advanced Solid Tumors

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • JAB-23E73 — DRUG
    Oral administration
  • JAB-23E73 — DRUG
    Oral administration
  • JAB-23E73 — DRUG
    Oral administration

Study Details

This study is to evaluate the safety and tolerability of pan-KRAS inhibitor JAB-23E73 in adult participants with advanced solid tumors

Key Dates

Start date
May 29, 2025
Status verified
Nov 2025
Primary completion
Nov 30, 2027
Completion
Feb 29, 2028

Study Design

Enrollment
294 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT

Arms

  • Experimental: Dose Escalation (Phase 1a)
    Evaluate overall Safety, tolerability, and determine MTD of JAB-23E73 monotherapy.
  • Experimental: Dose Expansion / Optimization Phase (Phase 1b)
    Determine RP2D of JAB-23E73 in patients with KRAS-alternated NSCLC or other selected tumors
  • Experimental: Indication Expansion (Phase 2a)
    Evaluate the preliminary antitumor activity of JAB-23E73 monotherapy at the RP2D in patients with advanced or metastatic CRC, PDAC, and other solid tumors.

Primary Outcome Measure

Dose Escalation (Phase 1a): Determine the Maximum tolerated dose (MTD) of JAB-23E73 monotherapy. [ Time Frame: Up to 1 year ]

Central Contacts

Locations (4)

FacilityCityStateZIPSite coordinators
Mayo ClinicRochesterMinnesota55905-
Washington UniversitySt LouisMissouri63110-
Cleveland Clinic FoundationClevelandOhio44195-
Huntsman Cancer InstituteSalt Lake CityUtah84112-

Find similar trials in Rochester, MN

By research site
Mayo Clinic· Rochester, MNWashington University· St Louis, MOCleveland Clinic Foundation· Cleveland, OHHuntsman Cancer Institute· Salt Lake City, UT

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