Radio- KO Radiotherapy for Knee Osteoarthritis Clinical Trial

Part of paid clinical trials in Rochester, Minnesota.

Sponsor
Mayo Clinic
Study ID
NCT06887829
Status
Recruiting
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Conditions

  • Osteoarthritis, Knee

Eligibility Criteria

Sex
ALL
Age
50 Years - 85 Years
Healthy Volunteers
Not accepted

Interventions

  • Low dose radiotherapy — RADIATION
    Participants will receive low dose radiotherapy (0.5 Gy) 3 times per week, for two weeks delivered via the X-Strahl Orthovoltage device.
  • Sham comparator — OTHER
    Participants will receive identical treatment 3 times per week, for two weeks delivered via the X-Strahl Orthovoltage device, without radiation.

Study Details

The primary aim of this study is to investigate whether low-dose radiotherapy is an effective treatment to reduce the pain of knee osteoarthritis. A secondary aim is to determine whether patients experience any more measurable side effects than those receiving sham treatments.

Key Dates

Start date
Jun 4, 2025
Status verified
Jun 2025
Primary completion
Jun 28, 2026
Completion
Jun 29, 2026

Study Design

Enrollment
128 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Low dose radiotherapy
    Low dose radiation therapy for knee osteoarthritis
  • Sham Comparator: Placebo
    No radiation therapy

Primary Outcome Measure

Change in Area Under the Curve (AUC) of ICOAP Scores [ Time Frame: Baseline, 6 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Mayo ClinicRochesterMinnesota55905
Family Medicine Research Study Coordinators
[email protected]
507-422-6823

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By research site
Mayo Clinic· Rochester, MN

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