Paid Clinical Trials in Pennsylvania

Pennsylvania has 3,674 paid clinical trials enrolling now across cities including Philadelphia, Pittsburgh and Hershey. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Pennsylvania include Penn Medicine, Children's Hospital of Philadelphia and UPMC, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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3,674 clinical trials

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An Extension Study of JR-141 to Evaluate the Long-term Safety and Efficacy in MPS II (Hunter Syndrome) Subjects

for Mucopolysaccharidosis II

2 locations incl. Oakland

Sponsor: JCR Pharmaceuticals Co., Ltd.

Sex: All·Age: All ages

Code: NCT05594992·Phase 3·Enrolling By Invitation

A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple Myeloma

for Multiple Myeloma

13 locations incl. San Francisco

Sponsor: K36 Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05651932·Phase 1·Recruiting

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Dose Attenuated Chemotherapy in Compromised Patients With Lung Cancer

for Lung Cancer

1 location in Philadelphia

Sponsor: Fox Chase Cancer Center

Sex: All·Age: 18+

Code: NCT05800587·Phase 2·Recruiting

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Decoding and Modulating Affective Brain States

for Rumination

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 65

Code: NCT05437705·Recruiting

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A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations

for Cancer Harboring BRAF Alterations

30 locations incl. Beverly Hills

Sponsor: Fore Biotherapeutics

Sex: All·Age: 10+

Code: NCT05503797·Phase 2·Recruiting

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Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low Weight Infants

for Ductus Arteriosus, Patent

24 locations incl. Birmingham

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 7 Days - 32 Days

Code: NCT05547165·Recruiting

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A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

for Childhood Medulloblastoma

101 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 4 - 21

Code: NCT05382338·Phase 3·Recruiting

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Biobehavioral Reward Responses Associated With Consumption of Nutritionally Diverse Ultra-Processed Foods

for Obesity

1 location in Philadelphia

Sponsor: Oregon Research Institute

Sex: All·Age: 18 - 65

Code: NCT05437809·Recruiting

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Safety Study of Tenapanor for the Treatment of Pediatric Patients (6 to Less Than 18 Years Old) With IBS-C

for Irritable Bowel Syndrome With Constipation (IBS-C)

Drug: Tenapanor

27 locations incl. Foley

Sponsor: Ardelyx

Sex: All·Age: 6 - 18

Code: NCT05905926·Phase 3·Enrolling By Invitation

Improve Outcomes for Older Allogeneic Transplant Recipients

for Allogeneic Transplantation

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 60+

Code: NCT05612789·Recruiting

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A Study to Evaluate the Safety and Tolerability of TOS-358 in Women With HR+ HER2- Breast Cancer

for HR+/HER2-negative Breast Cancer

9 locations incl. Chicago

Sponsor: Totus Medicines

Sex: Female·Age: 18+

Code: NCT05683418·Phase 1·Recruiting

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3D-Printed Versus Laboratory-Fabricated Hyrax Expanders

for Maxillary Expansion

2 locations incl. Pittsburgh

Sponsor: Ildeu Andrade Jr.

Sex: All·Age: 8 - 13·Accepts healthy volunteers

Code: NCT05743127·Recruiting

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Cortical Contributions to FFR: Post-Op Outcomes

for Language

1 location in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 13 - 25

Code: NCT05214092·Enrolling By Invitation

Building a Renewed ImaGe After Head & Neck Cancer Treatment (BRIGHT) Multi-Site RCT

for Head and Neck Cancer

5 locations incl. Detroit

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT05442957·Recruiting

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A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures

for Primary Generalized Tonic-Clonic Seizures

59 locations incl. Mobile

Sponsor: Xenon Pharmaceuticals Inc.

Sex: All·Age: 12+

Code: NCT05667142·Phase 3·Recruiting

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Neoadjuvant PD-1 Blockade in Resectable Merkel Cell Carcinoma

for Merkel Cell Carcinoma

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT05496036·Phase 2·Recruiting

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Long-term Safety and Tolerability of Inclisiran in Participants With HeFH or HoFH Who Have Completed the Pediatric ORION-16, ORION-13, ORION-20, or ORION-19 Studies

for Heterozygous or Homozygous Familial Hypercholesterolemia

Drug: Inclisiran

5 locations incl. Boca Raton

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 12 - 100

Code: NCT05682378·Phase 3·Recruiting

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A Precision Medicine Approach Using Gene Silencing to Treat a Chronic Liver Disease Called Metabolic Dysfunction-Associated Steatohepatitis (MASH) in Adult Participants at Increased Genetic Risk for This Condition

for Metabolic Dysfunction-Associated SteatoHepatitis (MASH)

61 locations incl. Chandler

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18 - 75

Code: NCT05519475·Phase 2·Recruiting

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Effect of CPAP on Blood Pressure in Excessively Sleepy Obstructive Sleep Apnea Subtype

for Obstructive Sleep Apnea

2 locations incl. Columbus

Sponsor: Ohio State University

Sex: All·Age: 18 - 75

Code: NCT05742360·Recruiting

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Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial

for Surgery

6 locations incl. Ann Arbor

Sponsor: University of Michigan

Sex: All·Age: 18+

Code: NCT05722002·Phase 4·Recruiting

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PUSH-IT Continuing Enteral Feeds for Tracheostomy

for Tracheostomy Complication

6 locations incl. Danbury

Sponsor: State University of New York at Buffalo

Sex: All·Age: 18+

Code: NCT05906472·Recruiting

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Testing Lutetium Lu 177 Dotatate in Patients With Somatostatin Receptor Positive Advanced Bronchial Neuroendocrine Tumors

for Advanced Lung Neuroendocrine Tumor

29 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04665739·Phase 2·Recruiting

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Pilot/Pivotal Study of DBS+Rehab After Stroke

for Stroke

10 locations incl. Phoenix

Sponsor: Enspire DBS Therapy, Inc.

Sex: All·Age: 21+

Code: NCT05701280·Recruiting

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A Study to Follow Patients With Adult Growth Hormone Deficiency (AGHD) Treated With Sogroya® for Long Term Safety Information

for Adult Growth Hormone Deficiency

29 locations incl. Phoenix

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT05718570·Enrolling By Invitation

EXErcise Regimen Designed to Improve Functional Mobility, Body Composition, and Strength After Treatment for Cancer

for Cancer

1 location in Pittsburgh

Sponsor: Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

Sex: All·Age: 20 - 89

Code: NCT06083324·Recruiting

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Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial

for Metastatic Renal Cell Carcinoma

313 locations incl. Birmingham

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT05327686·Phase 2·Recruiting

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Study of Neoadjuvant PARP Inhibition Followed by Radical Prostatectomy in Patients With Unfavorable Intermediate-Risk or High-Risk Prostate Cancer With Select HRR Gene Alterations

for Prostate Cancer

6 locations incl. La Jolla

Sponsor: Rana McKay, MD

Sex: Male·Age: 18+

Code: NCT05498272·Phase 2·Recruiting

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mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma

for Advanced Esophageal Adenocarcinoma

Drug: Nivolumab

785 locations incl. Birmingham

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT05677490·Phase 3·Recruiting

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The Impact of MeMed BV® on Management of Patients With Suspected Lower Respiratory Tract Infections (LRTI) in the Emergency Department (ED) and Urgent Care Center (UCC) ("JUPITER" TRIAL)

for Lower Respiratory Tract Infection

8 locations incl. Jacksonville

Sponsor: MeMed Diagnostics Ltd.

Sex: All·Age: 18 - 99

Code: NCT05762302·Recruiting

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Surgical Treatment of Peri-implantitis Using a Bone Substitute With or Without a Resorbable Collagen Membrane

for Peri-Implantitis

1 location in Pittsburgh

Sponsor: Andrea Ravida

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05699343·Enrolling By Invitation

RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty

for Mood Disorders

3 locations incl. Monroeville

Sponsor: University of Pittsburgh

Sex: All·Age: 18 - 100

Code: NCT05658796·Recruiting

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Clinical Trial for Integrated Care to Help At Risk Teen (iCHART) Intervention

for Suicide and Depression

13 locations incl. Gibbsboro

Sponsor: University of Pittsburgh

Sex: All·Age: 12 - 18

Code: NCT05748730·Recruiting

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Co-administration of CART22-65s and huCART19 for B-ALL

for B-cell Acute Lymphoblastic Leukemia

1 location in Philadelphia

Sponsor: Stephan Grupp MD PhD

Sex: All·Age: Up to 29

Code: NCT05674175·Phase 1, Phase 2·Recruiting

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The Path to Optimal Black Maternal Heart Health: Comparing Two CVD Risk Reduction Interventions (Change of HEART)

for Pregnancy Related

1 location in Philadelphia

Sponsor: Temple University

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT05499507·Recruiting

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Penn Family Screening for Familial Hypercholesterolemia

for Familial Hypercholesterolemia

1 location in Philadelphia

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT05750667·Enrolling By Invitation

Surveillance vs. Endoscopic Therapy for Barrett's Esophagus With Low-grade Dysplasia

for Barretts Esophagus With Dysplasia

23 locations incl. Los Angeles

Sponsor: University of Colorado, Denver

Sex: All·Age: 18 - 89

Code: NCT05753748·Recruiting

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A Study to See Iftolvaptan is Safe in Infants and Children Who at Enrollment Are 28 Days to Less Than 18 Years Old withAutosomal Recessive Polycystic Kidney Disease (ARPKD)

for Autosomal Recessive Polycystic Kidney (ARPKD)

12 locations incl. Washington D.C.

Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.

Sex: All·Age: 28 Days - 18

Code: NCT04782258·Phase 3·Recruiting

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Descemet Endothelial Thickness Comparison Trial II

for Fuchs

8 locations incl. Palo Alto

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT05275972·Phase 3·Recruiting

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A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Pallidotomy for the Treatment of Advanced, Idiopathic Parkinson's Disease With Medication-refractory Moderate to Severe Motor Complications

for Movement Disorders

4 locations incl. Baltimore

Sponsor: InSightec

Sex: All·Age: 30 - 99

Code: NCT05539196·Recruiting

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ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)

for H3 K27M

67 locations incl. Phoenix

Sponsor: Jazz Pharmaceuticals

Sex: All·Age: All ages

Code: NCT05580562·Phase 3·Recruiting

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