Improve Outcomes for Older Allogeneic Transplant Recipients

Conditions

• Allogeneic Transplantation

Eligibility Criteria

Sex

ALL

Age

60 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Exercise Program (Cohort A Prehab) — BEHAVIORAL
  Pre-frail and frail potential HCT recipients 60 years and older will participate in a supervised exercise program from the time of enrollment up until HCT admission. Exercise compliance will be measured in part through physical activity trackers.from time of discharge from HCT until day +100 post-HCT. All HCT recipients 60 years and older will participate in a supervised exercise program from the time of discharge from HCT admission until day +100 post-HCT. Exercise compliance will be measured in part through physical activity trackers.
• Exercise Program (Cohort B Rehab) — BEHAVIORAL
  All HCT recipients 60 years and older will participate in a supervised exercise program from the time of discharge from HCT admission until day +100 post-HCT. Exercise compliance will be measured in part through physical activity trackers.

Study Details

This is an interventional pilot study to determine whether implementation of a supervised exercise program can improve outcomes in subjects undergoing allogeneic HCT. The primary objective is to determine feasibility. Up to 60-72 evaluable subjects will be enrolled. Evaluable subjects are defined as those participating in the exercise intervention.

Key Dates

Start date

Feb 15, 2023

Status verified

Dec 2025

Primary completion

Jun 1, 2030

Completion

Jun 1, 2031

Study Design

Enrollment

72 participants (estimated)

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: Cohort A (Prehab)
  Pre-frail and frail subjects will attend at least twice weekly exercise sessions with a physical therapist and be given an exercise program to complete at home prior to admission for HCT. Patients enrolled in this cohort can continue on to Cohort B.
• Experimental: Cohort B (Rehab)
  All patients 60 years and older upon discharge from their initial hospital stay for HCT will attend at least weekly exercise sessions with a physical therapist and be given an exercise program to complete at home with sessions continued through Day +100 after HCT.

Primary Outcome Measure

Proportion of enrolled subjects who participate in the supervised exercise program [ Time Frame: From 3 months prior to HCT to 100 days after HCT ]

Central Contacts

• Jacqui Rick
  2152209675
  [email protected]

Locations (1)

Find similar trials in Philadelphia, PA

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