Surgical Treatment of Peri-implantitis Using a Bone Substitute With or Without a Resorbable Collagen Membrane

Part of paid clinical trials in Pittsburgh, Pennsylvania.

Sponsor
Andrea Ravida
Study ID
NCT05699343
Status
Enrolling By Invitation

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • InterOss Collagen (Bone xenograft) and InterOss Collagen Guide (Collagen membrane) — PROCEDURE
    Group will receive InterOss Collagen and InterOss Collagen Guide during surgical intervention visit.
  • InterOss Collagen (Bone xenograft) — PROCEDURE
    Group will only receive InterOss Collagen during surgical intervention visit.

Study Details

The objective of the present randomized clinical trial will be to compare two surgical methods of treating peri-implantitis. This study will determine if surgical debridement of peri-implantitis bone defects, including air powder abrasive (APA) decontamination of implant surfaces, in combination with the placement of a bone graft, differs in treatment outcomes compared to placing the same bone graft material with a resorbable collagen membrane placed over the bone graft.

Key Dates

Start date
Jan 30, 2023
Status verified
Feb 2026
Primary completion
Jan 31, 2028
Completion
Dec 31, 2028

Study Design

Enrollment
52 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Bone grafting with collagen membrane
    This arm will receive surgical intervention involving placement of a bone xenograft subsitute (InterOss Collagen) into the peri-implant bone defect with a collagen membrane (InterCollagen Guide) placed over the bone graft.
  • Active Comparator: Bone grafting without collagen membrane
    This arm will receive surgical intervention involving placement of a bone xenograft subsitute (InterOss Collagen) into the peri-implant bone defect with no collagen membrane placed over the graft.

Primary Outcome Measure

Successful Treatment of Peri-Implantitis [ Time Frame: 1 year ]

Locations (1)

FacilityCityStateZIPSite coordinators
University of Pittsburgh School of Dental MedicinePittsburghPennsylvania15213-

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University of Pittsburgh School of Dental Medicine· Pittsburgh, PA

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