Cortical Contributions to FFR: Post-Op Outcomes

Part of paid clinical trials in Pittsburgh, Pennsylvania.

Sponsor
University of Pittsburgh
Study ID
NCT05214092
Status
Enrolling By Invitation

Conditions

  • Language

Eligibility Criteria

Sex
ALL
Age
13 Years - 25 Years
Healthy Volunteers
Not accepted

Interventions

  • Speech sound stimulation — BEHAVIORAL
    Participants will listen to repetitive speech sound stimuli, presented through headphones, which will induce a neural response (frequency-following response) to be measured via electroencephalography and pupillometry

Study Details

The purpose of this study is to better understand cortical contributions of the human temporal lobe to the frequency-following response. Frequency-following responses (FFR) are electrophysiological recordings that reflect phase-locked activity of neural ensembles in the auditory pathway and are used as an indicator of the integrity of supra-threshold speech processing. FFR was first studied in subcortical areas, but recent consensus in the literature supports the notion that it is an integrated response between subcortical and cortical neural populations. The proposed study aims to deconstruct the role of the cortex in generating and modulating the FFR. The research team will build a novel computational model of FFR mechanisms and use EEG recordings from participants who have undergone resection of lesions in Heschl's gyrus to validate model predictions.

Key Dates

Start date
Feb 14, 2023
Status verified
Jan 2026
Primary completion
Jan 1, 2027
Completion
Jan 1, 2030

Study Design

Enrollment
10 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Neurosurgical Patients
    Patient participants with previously excised tissue within Heschl's gyrus (as dictated by clinical care)

Primary Outcome Measure

Pitch Decoding Accuracy [ Time Frame: During sEEG-EEG recording sessions, up to 3 hours total ]

Locations (1)

FacilityCityStateZIPSite coordinators
UPMC Children's Hospital of PittsburghPittsburghPennsylvania15224-

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UPMC Children's Hospital of Pittsburgh· Pittsburgh, PA

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