Paid Clinical Trials in Pennsylvania

Pennsylvania has 3,656 paid clinical trials enrolling now across cities including Philadelphia, Pittsburgh and Hershey. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Pennsylvania include Penn Medicine, Children's Hospital of Philadelphia and UPMC, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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3,656 clinical trials

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Comparative Effectiveness of Two Different Approaches to Radiofrequency Ablation of Lumbar Medial Branch Nerves

for Lumbar Spondylosis

1 location in Hershey

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: 18+

Code: NCT06283628·Not Yet Recruiting

Efficacy and Safety of Novosis Putty in Transforaminal Lumbar Interbody Fusion for Patients With Lumbar Degenerative Disc Disease

for Degenerative Disc Disease

5 locations incl. Baton Rouge

Sponsor: CGBio Inc.

Sex: All·Age: 21 - 80

Code: NCT07017634·Phase 3·Recruiting

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Impact Of Upadacitinib On The Frequency Of Acute Recurrent Anterior Uveitis In Patients With Axial Spondyloarthritis

for Axial Spondylarthritis (axSpA)

Drug: Upadacitinib

1 location in Philadelphia

Sponsor: CARE ARTHRITIS LTD.

Sex: All·Age: 18+

Code: NCT07018206·Phase 4·Not Yet Recruiting

Endo-SPONGE for Treatment of Anastomotic or Hartmann's Stump Leakages in Lower Pelvic Area

for Anastomotic Leaks

8 locations incl. Orlando

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT07035431·Recruiting

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A Clinical Trial of Early Ventilation in Amyotrophic Lateral Sclerosis (EVENT ALS)

for Amyotrophic Lateral Sclerosis (ALS)

3 locations incl. Hershey

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT07071935·Phase 2·Not Yet Recruiting

Trial of Ureteroscopy vs Steerable Continuous Flow Aspiration Technology

for Urolithiasis

3 locations incl. Birmingham

Sponsor: Calyxo, Inc.

Sex: All·Age: 18+

Code: NCT07101809·Recruiting

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Ketones for Opioid Craving

for Opioid Use Disorder

1 location in Wernersville

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 18 - 75

Code: NCT07128524·Phase 2·Not Yet Recruiting

Smoothie Program for Achieving and Resilient Kids

for Executive Functions (EF)

1 location in State College

Sponsor: Penn State University

Sex: All·Age: 7 - 9·Accepts healthy volunteers

Code: NCT07195474·Not Yet Recruiting

A Prospective Study of Pediatric Participants up to 16 Years of Age With Methylmalonic Acidemia (MMA) Due to Mutations in the MMUT Gene

for Methylmalonic Acidemia (MMA)

2 locations incl. Philadelphia

Sponsor: Genespire Srl

Sex: All·Age: Up to 16

Code: NCT07432880·Not Yet Recruiting

NEUROCUPLE™ as an Opioid Alternative Following Total Knee Arthroplasty

for Total Knee Arthroplasty Postoperative Pain

3 locations incl. Pittsburgh

Sponsor: Jacques E. Chelly

Sex: All·Age: 18+

Code: NCT07439666·Not Yet Recruiting

Fast TILs to Treat Metastatic Pleural Effusions From Epithelial or Mesothelial Primary Tumors

for Malignant Pleural Effusion

1 location in Pittsburgh

Sponsor: Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

Sex: All·Age: 18 - 79

Code: NCT07443020·Phase 1·Recruiting

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"Vasectomy: Right for Me?" Decision Support Tool

for Vasectomy

2 locations incl. San Francisco

Sponsor: University of Pittsburgh

Sex: Male·Age: 21 - 55

Code: NCT07451067·Not Yet Recruiting

Evaluating an Artificial Intelligence-Based Diagnostic Support Tool for Older Adults in Primary Care

for Diagnostic Support

1 location in Philadephia

Sponsor: University of Pennsylvania

Sex: All·Age: 65+

Code: NCT07553559·Not Yet Recruiting

A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)

for Cognitive Dysfunction

Drug: Donanemab

42 locations incl. Chandler

Sponsor: Eli Lilly and Company

Sex: All·Age: 55 - 85

Code: NCT07589595·Phase 2·Not Yet Recruiting

Impact of NOL - Nociception Level Index Intraoperative Monitoring on Perioperative Outcomes in Spine Surgery - a Quality Improvement Pilot

for Spine Surgery

1 location in Philadelphia

Sponsor: Medasense Biometrics Ltd

Sex: All·Age: 18+

Code: NCT07608276·Not Yet Recruiting

A Study to See if Lepodisiran Can Reduce Plaque in Coronary Arteries of Adults With Elevated Lp(a) Who Have Had Heart Events or Are at High Risk

for Atherosclerosis

Drug: Lepodisiran

17 locations incl. La Jolla

Sponsor: Eli Lilly and Company

Sex: All·Age: 45 - 80

Code: NCT07613294·Phase 3·Not Yet Recruiting

Testing the Combination of Anti-cancer Drugs, Tovorafenib Plus Rituximab, in Patients With Hairy Cell Leukemia

for Hairy Cell Leukemia

Drug: Rituximab

4 locations incl. Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06965114·Phase 1, Phase 2·Recruiting

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A Study to Compare the Efficacy and Safety of BMS-986353 (Zolacabtagene- Autoleucel / Zola-cel), CD19-CAR T Cells, Versus Standard of Care in Participants With Active Systemic Sclerosis

for Systemic Sclerosis

Drug: BMS-986353

16 locations incl. Scottsdale

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 16+

Code: NCT07335562·Phase 3·Recruiting

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A Study to Learn About How a New Pneumococcal Vaccine Works in Infants.

for Pneumococcal Disease

58 locations incl. Birmingham

Sponsor: Pfizer

Sex: All·Age: 42 Days - 211 Days·Accepts healthy volunteers

Code: NCT07629440·Phase 3·Recruiting

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A Phase 2b Study of the Effects of Camoteskimab in Adults With Moderate-to-Severe Atopic Dermatitis

for Atopic Dermatitis

33 locations incl. Birmingham

Sponsor: Apollo Therapeutics Ltd

Sex: All·Age: 18 - 65

Code: NCT07599813·Phase 2·Recruiting

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Open-label Study of SKY-GJB2 in Pediatric Subjects With GJB2-mediated Hearing Loss

for GJB2-mediated Hearing Loss

2 locations incl. Boston

Sponsor: Skylark Bio Inc.

Sex: All·Age: 9 Months - 7

Code: NCT07627971·Phase 1, Phase 2·Recruiting

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Testing Whether Cemiplimab (REGN2810) Plus CDX-1140 Given Prior to Surgery Are Better Than Cemiplimab (REGN2810) Alone in Patients With Stage III-IV Head and Neck Cancer

for Head and Neck Squamous Cell Carcinoma

Drug: Cemiplimab

6 locations incl. Irvine

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06980038·Phase 2·Recruiting

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Testing the Effectiveness of the Anti-cancer Drug, Mirdametinib, in Treating Relapsed, Refractory Chronic Lymphocytic Leukemia

for Recurrent Chronic Lymphocytic Leukemia

7 locations incl. Duarte

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07061951·Phase 2·Recruiting

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Sparrow Link Neuromodulation Device for Opioid Withdrawal Management in Hospitalized Adults With Opioid Use Disorder

for Opioid Withdrawal

1 location in Pittsburgh

Sponsor: Payel Roy

Sex: All·Age: 18+

Code: NCT07079826·Recruiting

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Radiation, Oral Vancomycin, and CAR-T for B-Cell Lymphomas

for Large B Cell Lymphoma

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT07478848·Phase 1·Not Yet Recruiting

Stimulation-Based Modulation of Spinal and Cortical Sensory Pathways

for Stroke

1 location in Pittsburgh

Sponsor: Peter C. Gerszten, MD

Sex: All·Age: 21 - 75·Accepts healthy volunteers

Code: NCT07401186·Recruiting

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Effect of Collagen Membrane on Ridge Preservation

for Dehiscence

1 location in Pittsburgh

Sponsor: Debora Dias

Sex: All·Age: 18 - 80

Code: NCT07580495·Recruiting

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Cardiometabolic Effects of Pecan Snacking in Prediabetes

for Prediabetes

1 location in University Park

Sponsor: Penn State University

Sex: All·Age: 25 - 65

Code: NCT07235358·Recruiting

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Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma

for Osteosarcoma

1 location in Hershey

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: 0 - 50

Code: NCT07321912·Phase 2·Recruiting

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A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight

for Obesity

Drug: Semaglutide

99 locations incl. Birmingham

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07564414·Phase 3·Recruiting

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A Study to Evaluate Axatilimab Versus Best Available Therapy in Pediatric Participants With Chronic Graft-Versus-Host Disease After at Least 2 Prior Lines of Systemic Therapy (AGAVE-256)

for Chronic Graft-versus-host-disease

11 locations incl. Duarte

Sponsor: Incyte Corporation

Sex: All·Age: 2 - 17

Code: NCT07124078·Phase 2·Recruiting

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Phase 1b/2a Study of EYC-0305 in Patients With Neovascular Age-related Macular Degeneration

for Neovascular (Wet) Age-Related Macular Degeneration

5 locations incl. Beverly Hills

Sponsor: Eyconis INC.

Sex: All·Age: 50+

Code: NCT07587515·Phase 1, Phase 2·Recruiting

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huCART19-IL18-eDHFR Cells in Relapsed/Refractory Follicular Lymphoma

for Relapsed or Refractory Follicular Lymphoma

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT07343934·Phase 1·Recruiting

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Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disorder (MND) in Persons With HIV

for Major Depressive Disorder

25 locations incl. Birmingham

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 70

Code: NCT06705478·Phase 2·Recruiting

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Adding Asciminib to Usual Treatment for Adults With Newly Diagnosed Philadelphia Chromosome Positive (Ph+) Acute Lymphoblastic Leukemia

for Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

8 locations incl. Orange

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 60+

Code: NCT06773936·Phase 2·Enrolling By Invitation

Rapid Antidepressant Dynamics in Acute Neuromodulation Treatments

for Depression

1 location in Pittsburgh

Sponsor: Marta Peciña, MD PhD

Sex: All·Age: 18 - 55

Code: NCT06976840·Recruiting

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Game-Based Intervention to Reduce Alcohol Use Among Youth

for Alcohol Problem

1 location in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 14 - 18·Accepts healthy volunteers

Code: NCT07463118·Not Yet Recruiting

Rezpegaldesleukin (NKTR-358) in New Onset Type 1 Diabetes Mellitus

for Type 1 Diabetes Mellitus

2 locations incl. Pittsburgh

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 8 - 45

Code: NCT07142252·Phase 2·Recruiting

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CART123 Cells With or Without Ruxolitinib in Relapsed/Refractory Acute Myeloid Leukemia

for Acute Myeloid Leukemia (AML)

Drug: Ruxolitinib

1 location in Philadelphia

Sponsor: Stephan Grupp MD PhD

Sex: All·Age: 0 - 29

Code: NCT07464951·Phase 1·Recruiting

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Early Signals of the Transition From Immune Quiescence to Activation in the Liver Allograft Microenvironment and in the Circulation

for Liver Transplant

10 locations incl. San Francisco

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 3 - 13

Code: NCT07549503·Phase 2·Recruiting

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