Stimulation-Based Modulation of Spinal and Cortical Sensory Pathways

Part of paid clinical trials in Pittsburgh, Pennsylvania.

Sponsor
Peter C. Gerszten, MD
Study ID
NCT07401186
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
21 Years - 75 Years
Healthy Volunteers
Accepted

Interventions

  • Bipolar Neural Stimulation Electrode — DEVICE
    All individuals enrolled in this study will receive electrical stimulation to the dorsal cervical spinal nerves using the FDA-cleared bipolar stimulating electrode routinely used as standard-of-care to monitor neural function, during which muscle activities will be recorded through intramuscular electromyography (EMGs), and sensory evoked cortical local field potentials (SSEPs) will be acquired simultaneously to characterize properties of the spinal sensory pathways.

Study Details

The goal of this study is to assess cervical (neck) reflexes by intra-operatively stimulating the neck nerve roots to evoke motor responses through their connections to spinal motoneurons. This data is critical to reveal changes to the spinal sensory modulating circuitry in neurological disorders like stroke.

Key Dates

Start date
May 26, 2026
Status verified
Jun 2026
Primary completion
Aug 31, 2027
Completion
Jan 31, 2028

Study Design

Enrollment
15 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Dorsal Spinal Nerve Root Stimulation
    Individuals undergoing cervical spinal surgery will receive direct electrical stimulation to the cervical dorsal spinal nerve roots.

Primary Outcome Measure

Spinal Circuit Excitability [ Time Frame: 1 day ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of PittsburghPittsburghPennsylvania15213
Peter C Gerszten, MD
[email protected]
412-647-0958
Sydney Bader
412-648-4196
Peter C Gerszten, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Pittsburgh, PA

By condition
Stroke
By specialty
NeurologyBrain disorders
By research site
University of Pittsburgh· Pittsburgh, PA

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