Paid Clinical Trials in North Carolina

North Carolina has 2,930 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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2,930 clinical trials

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BandPass: A Remote Monitoring System for Sarcopenia and Functional Decline Phase II Aim 4

for Sarcopenia

2 locations incl. Chapel Hill

Sponsor: SynchroHealth LLC

Sex: All·Age: 65+

Code: NCT07421648·Not Yet Recruiting

Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections

for Gonorrhea

13 locations incl. Los Angeles

Sponsor: Westat

Sex: Female·Age: 13 - 29

Code: NCT06738407·Phase 4·Recruiting

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A Study to Test Whether BI 3802876 is Tolerated in People With Compensated Liver Cirrhosis Due to Metabolic Dysfunction- Associated Steatohepatitis (MASH)

for Liver Cirrhosis

Drug: BI 3802876

26 locations incl. Chandler

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18 - 75

Code: NCT07325526·Phase 2·Recruiting

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An Open-label, Single-arm Study of Prophylaxis for Datopotamab Deruxtecan (Dato-DXd) -Related Stomatitis in Eligible Patients With Metastatic or Inoperable Locally Recurrent Breast Cancer or Locally Advanced or Metastatic Epidermal Growth Factor Receptor-Mutated Non-small Cell Lung Cancer.

for Stomatitis

20 locations incl. Tucson

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07357597·Phase 4·Not Yet Recruiting

PREDICT-RD: ctDNA Surveillance in TNBC With Residual Disease

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07069595·Phase 2·Recruiting

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Effectiveness and Adverse-effect Switch Evaluation of Xanomeline and Trospium Chloride (KarXT)

for Schizophrenia

Drug: KarXT

45 locations incl. Bryant

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07379827·Recruiting

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A Study to Evaluate the Effectiveness of Two Doses of AP-472 as Adjunctive Therapy to Levodopa in Parkinson's Disease (PD) Participants With Motor Fluctuations

for Parkinson Disease

25 locations incl. Little Rock

Sponsor: Appello Pharmaceuticals, Inc.

Sex: All·Age: 30 - 80

Code: NCT07432958·Phase 2·Recruiting

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Evaluating the Safety and Efficacy of dNerva Lung Denervation System in Patients With COPD

for COPD

10 locations incl. Birmingham

Sponsor: Nuvaira, Inc.

Sex: All·Age: 40 - 80

Code: NCT07051707·Recruiting

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Neural Mechanisms of Light Driven Analgesia

for Musculoskeletal Pain

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07245303·Recruiting

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AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight

for Obesity

Drug: NNC0487-0111

22 locations incl. Miramar

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07339423·Phase 3·Recruiting

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A Study to Learn About the Study Medicine (PF-08653944) in People With Obesity or Overweight and Type 2 Diabetes (T2D)

for Obesity

35 locations incl. Anaheim

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07400653·Phase 3·Recruiting

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Biomarker Directed Trial of Temozolomide and Stenoparib in Relapsed SCLC

for Relapsed Small Cell Lung Cancer

11 locations incl. Palo Alto

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT06681220·Phase 1, Phase 2·Recruiting

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PK, Safety and Preliminary Efficacy Study of Montelukast in Critically Ill Infants With Developing Bronchopulmonary Dysplasia

for Bronchopulmonary Dysplasia (BPD)

5 locations incl. Little Rock

Sponsor: Duke University

Sex: All·Age: 7 Days - 28 Days

Code: NCT07101640·Phase 1, Phase 2·Recruiting

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Nalmefene Implant in Healthy Subjects

for Opioid Abuse and Addiction

1 location in Morrisville

Sponsor: ReacX Pharmaceuticals, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07325279·Phase 1·Recruiting

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A Study Comparing AZD0120, a Dual-targeted CAR-T Against B-cell Maturation Antigen (BCMA) and CD19, Versus Standard Regimens in Participants With Relapsed Refractory Multiple Myeloma (DURGA-4)

for Relapsed Refractory Multiple Myeloma

48 locations incl. Gilbert

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07391657·Phase 3·Recruiting

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A Study of FG-3246 in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC)

for Metastatic Castration-Resistant Prostate Cancer

20 locations incl. Goodyear

Sponsor: Kyntra Bio

Sex: Male·Age: 18+

Code: NCT06842498·Phase 2·Recruiting

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Testing the Addition of an Anti-Cancer Drug, Cabozantinib to the Immunotherapy Drug Cemiplimab (REGN2810), in Adolescents and Adults With Advanced Adrenocortical Cancer

for Locally Advanced Adrenal Cortical Carcinoma

Drug: Cabozantinib

69 locations incl. La Jolla

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12+

Code: NCT06900595·Phase 2·Recruiting

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A Study to Learn How Stargardt-type Eye Conditions Progress in Children and Adults

for Stargardt Disease

7 locations incl. Phoenix

Sponsor: Astellas Pharma Global Development, Inc.

Sex: All·Age: 6+

Code: NCT07425574·Recruiting

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AURN001 Efficacy in Participants With Corneal Edema Secondary to Corneal Endothelial Dysfunction

for Corneal Edema

12 locations incl. Mesa

Sponsor: Aurion Biotech

Sex: All·Age: 18+

Code: NCT07368959·Phase 3·Recruiting

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Optimizing Recovery in Trauma Patients by Integrating Enhanced Nutrition Delivery

for Trauma

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 45+

Code: NCT06521086·Recruiting

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A Study to Assess the Safety and Efficacy of Different Doses of ELV001 to Treat Active Rheumatoid Arthritis in Patients With an Inadequate Response to Methotrexate and Tumor Necrosis Factor Inhibition (START SYNERGY)

for Active Rheumatoid Arthritis

22 locations incl. Gilbert

Sponsor: Elevara Medicines Limited

Sex: All·Age: 18 - 75

Code: NCT07409103·Phase 2·Recruiting

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A Study to Assess the Effectiveness and Safety of IPN10200 Over Time in Adults With Moderate to Severe Wrinkle-like Lines Between the Eyebrows

for Moderate to Severe Glabellar Lines

41 locations incl. Los Angeles

Sponsor: Ipsen

Sex: All·Age: 18 - 80

Code: NCT07435428·Phase 3·Recruiting

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Connectomic Guided DBS for Parkinson's Disease

for Parkinson Disease

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06618157·Enrolling By Invitation

A Study to Find Out if BI 764198 Helps Adults and Adolescents With a Kidney Condition Called Focal Segmental Glomerulosclerosis (FSGS)

for Focal Segmental Glomerulosclerosis

65 locations incl. Alabaster

Sponsor: Boehringer Ingelheim

Sex: All·Age: 12+

Code: NCT07220083·Phase 3·Recruiting

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Sugary Drink Labeling Study

for Health Behavior

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07294053·Recruiting

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Evolutionary Clinical Trial for Novel Biomarker-Driven Therapies

for Breast Cancer

2 locations incl. Rochester

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07340541·Phase 2·Recruiting

Apply to this trial

Impacts of Sugar Warnings on Weight Bias

for Nutrition

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07346001·Recruiting

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COMO: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME

for Diabetic Macular Edema

Drug: Aflibercept

50 locations incl. Bakersfield

Sponsor: EyePoint Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT07449936·Phase 3·Recruiting

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Ultrasound Imaging of the Head, Neck, and Airway

for Healthy

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07406061·Not Yet Recruiting

Zinc Supplementation in Sickle Cell Disease: A Precursor to the Think Zinc for Bones Trial

for Sickle Cell Disease

6 locations incl. Oakland

Sponsor: University of California, San Francisco

Sex: All·Age: 15 - 40

Code: NCT06260891·Phase 2·Recruiting

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Using PrEP, Doing It for Ourselves

for HIV Prevention

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT06638892·Recruiting

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Comparing Digital Therapy, Trazodone, and Daridorexant for Menopause-Related Insomnia Symptoms

for Menopausal Women

Drug: Daridorexant

5 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: Female·Age: 40 - 62

Code: NCT07136415·Phase 4·Recruiting

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Anti-Ly6E Exatecan ADC M7437 in Advanced Solid Tumors

for Advanced Solid Tumors

4 locations incl. New Haven

Sponsor: EMD Serono Research & Development Institute, Inc.

Sex: All·Age: 18+

Code: NCT07360314·Phase 1·Recruiting

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Comparative Study of High Performance Low-Cost Optical Coherence Tomography (Stage 1B, 2 and 3)

for Optical Coherence Tomography of Retina

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT07425106·Enrolling By Invitation

A Trial to Investigate Safety, Exposure, and Efficacy of HU6 Compared With Placebo in Adult Participants With Metabolic Dysfunction-associated Steatohepatitis (MASH)

for MASH - Metabolic Dysfunction-Associated Steatohepatitis

31 locations incl. Chandler

Sponsor: Rivus Pharmaceuticals, Inc.

Sex: All·Age: 30+

Code: NCT07491458·Phase 2·Recruiting

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Clinical Trial of Omalizumab for Allergen Sensitized and Exposed Individuals With COPD

for Chronic Obstructive Pulmonary Disease (COPD)

Drug: Omalizumab

23 locations incl. Birmingham

Sponsor: Johns Hopkins University

Sex: All·Age: 40+

Code: NCT07059091·Phase 2·Recruiting

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Distance-Based Exercise to Preserve Function and Prevent Disability

for Hematopoietic and Lymphatic System Neoplasm

17 locations incl. Dublin

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT07059884·Recruiting

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A Novel Dialectical Behavior Therapy Brief Group Intervention for Cigarette Smoking by Patients With Cancer: An Open Clinical Trial

for Smoking Behavior

2 locations incl. Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT07119489·Recruiting

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A Phase 2b Study Evaluating Oral VH4524184 Regimens in Treatment Naïve Persons With HIV-1 (INNOVATE Study)

for HIV Infections

32 locations incl. Bakersfield

Sponsor: ViiV Healthcare

Sex: All·Age: 18+

Code: NCT07202546·Phase 2·Recruiting

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A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate to Severe Chronic Obstructive Pulmonary Disease

for Moderate to Severe Chronic Obstructive Pulmonary Disease

Drug: PF-07275315

30 locations incl. Dothan

Sponsor: Pfizer

Sex: All·Age: 35 - 80

Code: NCT07363694·Phase 2, Phase 3·Recruiting

Apply to this trial