Paid Clinical Trials in North Carolina

North Carolina has 2,930 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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2,930 clinical trials

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A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.

for Sepsis

16 locations incl. Tucson

Sponsor: AstraZeneca

Sex: All·Age: 18 - 80

Code: NCT07215702·Phase 2·Recruiting

Apply to this trial

A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin

for Overweight

Drug: Eloralintide

54 locations incl. Birmingham

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07392190·Phase 3·Recruiting

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A Multicenter, Randomized, Double-Masked, Placebo-Controlled Pilot Study to Evaluate the Efficacy and Safety of ZOC2017217 in Subjects With Age-Related Cataract

for Age Related Cataracts

21 locations incl. Scottsdale

Sponsor: Ocusun Ophthalmic Pharmaceutical (Guangzhou) Co., Ltd.

Sex: All·Age: 50+

Code: NCT07395986·Phase 2·Enrolling By Invitation

A Double-blind, Randomized Controlled Trial to Investigate the Efficacy, Safety, and Pharmacokinetics of Pegloticase Administration Via Subcutaneous and Intravenous Routes Both With Methotrexate in Participants With Uncontrolled Gout

for Uncontrolled Gout

48 locations incl. Birmingham

Sponsor: Amgen

Sex: All·Age: 18+

Code: NCT07388498·Phase 3·Recruiting

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CAPRI: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME

for Diabetic Macular Edema

Drug: Aflibercept

48 locations incl. Gilbert

Sponsor: EyePoint Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT07449923·Phase 3·Recruiting

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A Study to Develop a Blood-based Test for Aiding the Diagnosis/Prognosis of Traumatic Brain Injury in Adults and for Monitoring the Development of Secondary Events in Patients Diagnosed With Traumatic Brain Injury

for Traumatic Brain Injury

13 locations incl. Sacramento

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT07455136·Recruiting

Apply to this trial

mHealth-supported Skills Training for Alcohol-Related Suicidality

for Alcohol Drinking

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT05847504·Enrolling By Invitation

BELUGA: Better to Exchange ETT for LMA Before Extubation in Children Under General Anaesthesia

for Endotracheal Extubation

2 locations incl. Winston-Salem

Sponsor: Telethon Kids Institute

Sex: All·Age: 0 - 16

Code: NCT07204990·Recruiting

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A Study to Learn About the Effects of Cemsidomide in Combination With Elranatamab in Relapsed/Refractory Multiple Myeloma Subjects

for Multiple Myeloma (MM)

Drug: Elranatamab

16 locations incl. Gilbert

Sponsor: C4 Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07280013·Phase 1·Recruiting

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A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes

for Obesity

Drug: Eloralintide

41 locations incl. Tuscaloosa

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07321886·Phase 3·Recruiting

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A Study of CX11 Tablets in Patients With Type 2 Diabetes Mellitus

for Type II Diabetes Mellitus

31 locations incl. Birmingham

Sponsor: Corxel Pharmaceuticals

Sex: All·Age: 18 - 75

Code: NCT07340320·Phase 2·Recruiting

Apply to this trial

Respiration From Pleth Validation

for Respiratory Rate Monitoring

1 location in Durham

Sponsor: Philips Clinical & Medical Affairs Global

Sex: All·Age: 4+

Code: NCT07449715·Recruiting

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Prophylactic TBR on Phantom Limb Pain

for Phantom Limb Pain After Amputation

1 location in Charlotte

Sponsor: OrthoCarolina Research Institute, Inc.

Sex: All·Age: 13+

Code: NCT06956508·Enrolling By Invitation

Metastatic Ewing's Trial Testing Schedule Enhancement to Improve Outcomes

for Metastatic Ewing Sarcoma

17 locations incl. Birmingham

Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All·Age: 1+

Code: NCT07194044·Phase 1·Recruiting

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A Study to Evaluate the Efficacy, Safety, and Tolerability of VIM0423 in Individuals With Isolated Dystonia

for Dystonia

37 locations incl. Birmingham

Sponsor: Vima Therapeutics

Sex: All·Age: 18 - 65

Code: NCT07304089·Phase 2·Recruiting

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SDM POSSIBLE: A Breast Cancer Treatment Decision Aid for Women 70+ With Low-Risk Stage I Breast Cancers

for Breast Cancer

11 locations incl. Los Angeles

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT06896474·Recruiting

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Study of AGN-151607-DP to Assess Adverse Events and Change in Disease Activity in Adult Participants Undergoing Open Abdominal Ventral Hernia Repair

for Ventral Hernia

11 locations incl. Riverside

Sponsor: AbbVie

Sex: All·Age: 18 - 80

Code: NCT07226791·Phase 2·Recruiting

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A Study Comparing JNJ-79635322 and an Anti-B-cell Maturation Antigen (BCMA)xCD3 Bispecific Antibody in Participants With Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma

23 locations incl. Los Angeles

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT07258511·Phase 3·Recruiting

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Duke Virtual IntEgrated Workflow

for Falls Injury

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07406074·Not Yet Recruiting

A Study to Assess the Safety and Tolerability of BMS-986525 Alone and in Combination With Nivolumab in Participants With Relapsed/Refractory Small Cell Lung Cancer

for Relapsed/Refractory Small Cell Lung Cancer

Drug: Nivolumab

5 locations incl. Detroit

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07325136·Phase 1, Phase 2·Recruiting

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Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2

for Gastric Cancer

Drug: Sonesitatug vedotin

77 locations incl. Phoenix

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07431281·Phase 3·Recruiting

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A Phase 2 Study of LTI-03 in Patients With Idiopathic Pulmonary Fibrosis

for Idiopathic Pulmonary Fibrosis (IPF)

11 locations incl. Birmingham

Sponsor: Rein Therapeutics

Sex: All·Age: 40+

Code: NCT06968845·Phase 2·Recruiting

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GATEWAY: Safety Evaluation of the MiniMed™ NMX8-AID System in Children and Adults Living With Diabetes

for Type 1 Diabetes Mellitus

34 locations incl. Little Rock

Sponsor: Medtronic MiniMed, Inc.

Sex: All·Age: 7 - 85

Code: NCT07228117·Recruiting

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Hyaluronic Acid-based Gel Spacers in Gynecologic Malignancies

for Cervix Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 18+

Code: NCT07292818·Phase 1·Recruiting

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Study to Evaluate the REMEDY SPECTRUM GV IM Spacer Nail in the Treatment of Ankle-Related Infections

for Periprosthetic Joint Infection

3 locations incl. Lansing

Sponsor: OsteoRemedies, LLC

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT06428448·Phase 2·Recruiting

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Personalized Care for Prenatal Stress Reduction & Prevention of Preterm Birth (PTB) Disparities

for Preterm Birth Complication

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: Female·Age: 18+

Code: NCT06915428·Not Yet Recruiting

Enhancing Heart Allograft Function With the OCS Heart System Trial

for Heart Transplant

8 locations incl. San Francisco

Sponsor: TransMedics

Sex: All·Age: 18+

Code: NCT07145515·Recruiting

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Phase 2 Study of Disease Risk Mutation-Guided Finite Acalabrutinib+Venetoclax for Relapsed CLL Post-1L Finite cBTKi+BCL2i ± Obinutuzumab

for Chronic Lymphocytic Leukemia (CLL)

Drug: Venetoclax

3 locations incl. Boston

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT07024706·Phase 2·Not Yet Recruiting

Increasing Germline Genetic Testing for Patients With Cancer

for Hereditary Pancreatic Cancer

10 locations incl. Los Angeles

Sponsor: Josh Peterson

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07307664·Recruiting

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A Prospective Multicenter Clinical Investigation Evaluating the Accuracy of the Trimline Design When Treated With SureSmile® Aligners.

for Malocclusion

4 locations incl. Fresno

Sponsor: Dentsply Sirona Implants and Consumables

Sex: All·Age: 18+

Code: NCT07290790·Recruiting

Apply to this trial

A Trial of TAK-861 for the Treatment of Narcolepsy With Cataplexy

for Narcolepsy Type 1 (NT1)

11 locations incl. Redwood City

Sponsor: Takeda

Sex: All·Age: 16 - 70

Code: NCT07363720·Phase 3·Recruiting

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Study to Evaluate the Safety and Efficacy of Larsucosterol in Participants With Alcohol-associated Hepatitis (AH)

for Hepatitis

Drug: Larsucosterol

48 locations incl. Birmingham

Sponsor: Bausch Health Americas, Inc.

Sex: All·Age: 18+

Code: NCT07428538·Phase 3·Recruiting

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Double-blind, Randomized Clinical Trial Evaluating the Efficacy and Safety of Vormatrigine in Adults With Focal Seizures

for Focal Epilepsy

7 locations incl. Miami

Sponsor: Praxis Precision Medicines

Sex: All·Age: 18 - 85

Code: NCT07505004·Phase 3·Recruiting

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Sparing Parotid Ducts Via MRI Sialography for Reduced Patient-Reported Xerostomia

for Head and Neck Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07278557·Phase 2·Recruiting

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A Study of KT-621 Administered Orally to Adult Participants With Moderate to Severe Eosinophilic Asthma

for Eosinophilic Asthma

20 locations incl. Long Beach

Sponsor: Kymera Therapeutics, Inc.

Sex: All·Age: 18 - 75

Code: NCT07323654·Phase 2·Recruiting

Apply to this trial

Intestinal Microbiome Transplant in ALS

for Amyotrophic Lateral Sclerosis ALS

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07017946·Phase 1, Phase 2·Recruiting

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Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer

for Advanced Endometrial Carcinoma

Drug: Bevacizumab

211 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT07198074·Phase 3·Recruiting

Apply to this trial

A Study of JNJ-90301900 in Combination With Chemoradiation Therapy in Participants With Locally Advanced Head and Neck Squamous Cell Carcinoma

for Squamous Cell Carcinoma of Head and Neck

8 locations incl. Birmingham

Sponsor: Johnson & Johnson Enterprise Innovation Inc.

Sex: All·Age: 18 - 74

Code: NCT07219212·Phase 1·Recruiting

Apply to this trial

A Long-Term Extension Study of IMVT-1402 in Adult Participants With Graves' Disease (GD)

for Graves' Disease

Drug: IMVT-1402

89 locations incl. Phoenix

Sponsor: Immunovant Sciences GmbH

Sex: All·Age: 18+

Code: NCT07286006·Phase 2·Enrolling By Invitation

ONC-MM-2407: The Effect of Virtual Reality Headsets on Pain and Anxiety in the Peri and Post Bone Marrow Biopsy Period

for Hematologic Malignancy

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT07203534·Recruiting

Apply to this trial