A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin

Part of paid clinical trials in Birmingham, Alabama.

Sponsor
Eli Lilly and Company
Study ID
NCT07392190
Phase
PHASE3
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Eloralintide — DRUG
    Administered SC
  • Placebo — DRUG
    Administered SC

Study Details

The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with placebo in participants with persistent obesity or overweight, with or without type 2 diabetes, and on stable incretin background therapy. Participation in the study will last about 80 weeks.

Key Dates

Start date
Feb 10, 2026
Status verified
Jun 2026
Primary completion
Jun 30, 2028
Completion
Jul 31, 2028

Study Design

Enrollment
900 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Eloralintide Dose 1
    Participants will receive eloralintide subcutaneously (SC)
  • Experimental: Eloralintide Dose 2
    Participants will receive eloralintide SC
  • Experimental: Eloralintide Dose 3
    Participants will receive eloralintide SC
  • Experimental: Eloralintide Dose 4
    Participants will receive eloralintide SC
  • Placebo Comparator: Placebo
    Participants will receive placebo SC

Primary Outcome Measure

Percent Change from Baseline in Body Weight [ Time Frame: Baseline, Week 64 ]

Central Contacts

  • Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
    317-615-4559
    [email protected]
  • Physicians interested in becoming principal investigators please contact
    [email protected]

Locations (54)

FacilityCityStateZIPSite coordinators
Birmingham Clinical ResearchBirminghamAlabama35209
205-870-4343
Nova Law (PRINCIPAL_INVESTIGATOR)
RIO Clinical Trials - PhoenixPhoenixArizona85016
480-966-7882
Kenneth Steil (PRINCIPAL_INVESTIGATOR)
Headlands Research - ScottsdaleScottsdaleArizona85260
480-725-8708
Benjamin Clark (PRINCIPAL_INVESTIGATOR)
Novak Clinical Research - Tucson - North La Cholla BoulevardTucsonArizona85741
Thili Kulatilake (PRINCIPAL_INVESTIGATOR)
Irvine Clinical ResearchIrvineCalifornia92614
949-753-1663
Elly Lee (PRINCIPAL_INVESTIGATOR)
Scripps Whittier Diabetes InstituteLa JollaCalifornia92037
858-824-5352
Athena Philis-Tsimikas (PRINCIPAL_INVESTIGATOR)
Peninsula Research AssociatesRolling Hills EstatesCalifornia90274
310-265-1623
Lawrence Sher (PRINCIPAL_INVESTIGATOR)
Care Access - SacramentoSacramentoCalifornia95831
925-734-2331
Francisco Garcia (PRINCIPAL_INVESTIGATOR)
Artemis Institute for Clinical ResearchSan DiegoCalifornia92123
858-278-3647
Stacey Layle (PRINCIPAL_INVESTIGATOR)
Southern California Clinical ResearchSanta AnaCalifornia92701
714-474-2173
Wayne Ho (PRINCIPAL_INVESTIGATOR)
University Clinical Investigators, Inc.TustinCalifornia92780
714-734-7944
Joanna Van (PRINCIPAL_INVESTIGATOR)
New England Research Associates, LLCBridgeportConnecticut06606
203-374-9816
Ilja Hulinsky (PRINCIPAL_INVESTIGATOR)
Yale University School of MedicineNew HavenConnecticut06519
203-785-7421
Ania Jastreboff (PRINCIPAL_INVESTIGATOR)
Chase Medical Research, LLCWaterburyConnecticut06708
203-419-4420
Joseph Soufer (PRINCIPAL_INVESTIGATOR)
JEM Research InstituteAtlantisFlorida33462
561-968-2933
David Halpert (PRINCIPAL_INVESTIGATOR)
AMR ClinicalDoralFlorida33172
Abid Chaudhry (PRINCIPAL_INVESTIGATOR)
Northeast Research Institute (NERI)Fleming IslandFlorida32003
904-541-8225
Senan Sultan (PRINCIPAL_INVESTIGATOR)
Jacksonville Center for Clinical ResearchJacksonvilleFlorida32216
904-730-0101
Alpa Patel (PRINCIPAL_INVESTIGATOR)
New Horizon Research CenterMiamiFlorida33165
305-226-3933
Lazaro Nunez (PRINCIPAL_INVESTIGATOR)
St Johns Center for Clinical ResearchSaint AugustineFlorida32086
904-209-0043
Ameeth Vedre (PRINCIPAL_INVESTIGATOR)
Metabolic Research Institute, Inc.West Palm BeachFlorida33401
561-802-3060
Barry Horowitz, MD (PRINCIPAL_INVESTIGATOR)
Teak Research Consults - DunwoodyDunwoodyGeorgia30338
470-403-4755
Aakar Thaker (PRINCIPAL_INVESTIGATOR)
Center for Advanced Research & EducationGainesvilleGeorgia30501
770-534-5154
Angela Ritter (PRINCIPAL_INVESTIGATOR)
Family First Medical CenterIdaho FallsIdaho83404
208-552-7700
Flint Packer (PRINCIPAL_INVESTIGATOR)
Great Lakes Clinical Trials - RavenswoodChicagoIllinois60640
773-275-3500 Ext 126
Rupal Trivedi (PRINCIPAL_INVESTIGATOR)
Iowa Diabetes and Endocrinology Research CenterWest Des MoinesIowa50266
515-329-6800
Robert Burr (PRINCIPAL_INVESTIGATOR)
Cotton O'Neil Diabetes & EndocrinologyTopekaKansas66606
785-354-9591
susan brian (PRINCIPAL_INVESTIGATOR)
AMR ClinicalLexingtonKentucky40509
859-264-8999
Mark Adams (PRINCIPAL_INVESTIGATOR)
IMA Clinical Research Monroe - ArmandMonroeLouisiana71201
Clinton Guillory (PRINCIPAL_INVESTIGATOR)
Centennial Medical GroupColumbiaMaryland21045
410-730-3399
Rajiv Dua (PRINCIPAL_INVESTIGATOR)
Brigham and Women's Hospital Diabetes ProgramBostonMassachusetts02115
617-732-4245
Vanita Aroda (PRINCIPAL_INVESTIGATOR)
MedVadis Research CorporationWalthamMassachusetts02451
617-744-1310
David DiBenedetto (PRINCIPAL_INVESTIGATOR)
Great Lakes Research InstituteSouthfieldMichigan48075
248-864-5242
Derrick Williamson (PRINCIPAL_INVESTIGATOR)
Arcturus Healthcare , PLC, Troy Internal Medicine Research DivisionTroyMichigan48098
248-312-0025
Neil Fraser (PRINCIPAL_INVESTIGATOR)
Clinical Research ProfessionalsChesterfieldMissouri63005
636-220-1200
Timothy Jennings (PRINCIPAL_INVESTIGATOR)
IMA Clinical Research ManhattanNew YorkNew York10036
Eli Shalenberg (PRINCIPAL_INVESTIGATOR)
NYU Langone HealthNew YorkNew York10016
212-263-3166
Holly Lofton (PRINCIPAL_INVESTIGATOR)
Weill Cornell Medical CollegeNew YorkNew York10021
646-962-2111
Louis Aronne (PRINCIPAL_INVESTIGATOR)
University of North Carolina Medical CenterChapel HillNorth Carolina27514
984-974-3004
Klara Klein (PRINCIPAL_INVESTIGATOR)
Medication ManagementGreensboroNorth Carolina27405
336-763-6968
James Franklin (PRINCIPAL_INVESTIGATOR)
Carteret Medical GroupMorehead CityNorth Carolina28557
252-499-8623
Mary Lawrence (PRINCIPAL_INVESTIGATOR)
Accellacare - Wilmington - 1917 Tradd CourtWilmingtonNorth Carolina28401
910-799-5500
John Parker (PRINCIPAL_INVESTIGATOR)
Care Access - LimaLimaOhio45805
Jimmy Alele (PRINCIPAL_INVESTIGATOR)
Preferred Primary Care Physicians, Preferred Clinical Research (Ofc 18)PittsburghPennsylvania15236
412-650-6155
Bryce Palchick (PRINCIPAL_INVESTIGATOR)
UT Southwestern Medical CenterDallasTexas75390
Amy Shah (PRINCIPAL_INVESTIGATOR)
Juno ResearchHoustonTexas77040
713-779-5494
Damaris Vega (PRINCIPAL_INVESTIGATOR)
Activian Clinical ResearchKingwoodTexas77339
832-969-3401
Martin Basaldua (PRINCIPAL_INVESTIGATOR)
Texas Valley Clinical Research (TVCR) - MissionMissionTexas78572
Alejandro Gonzalez Campos (PRINCIPAL_INVESTIGATOR)
Synergy Groups Medical LLC - Missouri CityMissouri CityTexas77459
832-532-4210
Deirdre McMullen (PRINCIPAL_INVESTIGATOR)
Endeavor Clinical TrialsSan AntonioTexas78240
518-428-6859
Nitendra Agarwal (PRINCIPAL_INVESTIGATOR)
IMA Clinical Research San AntonioSan AntonioTexas78229
210-692-7157
Priscilla Thomas (PRINCIPAL_INVESTIGATOR)
Consano Clinical Research, LLCShavano ParkTexas78231
210-545-4900
Michelle Welch (PRINCIPAL_INVESTIGATOR)
Texas Valley Clinical ResearchWeslacoTexas78596
956-431-8090
Eduardo Luna (PRINCIPAL_INVESTIGATOR)
Medrasa Clinical ResearchWylieTexas75098
469-449-3645
Tanvir Ahmad (PRINCIPAL_INVESTIGATOR)

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