A Study of KT-621 Administered Orally to Adult Participants With Moderate to Severe Eosinophilic Asthma

Part of paid clinical trials in Long Beach, California.

Sponsor
Kymera Therapeutics, Inc.
Study ID
NCT07323654
Phase
PHASE2
Status
Recruiting
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Conditions

  • Eosinophilic Asthma

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • KT-621 — DRUG
    Oral drug
  • Placebo — OTHER
    Oral placebo matched to KT-621

Study Details

This Phase 2b study is designed to evaluate the safety and efficacy of KT-621 in participants with uncontrolled moderate to severe eosinophilic asthma. The main goals of this study are to investigate how effective KT-621 is at treating uncontrolled moderate to severe eosinophilic asthma, the safety and tolerability of KT-621, and how KT-621 behaves in the body.

Key Dates

Start date
Jan 28, 2026
Status verified
Jan 2026
Primary completion
Dec 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
264 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Group 1: KT-621 Dose 1
  • Experimental: Group 2: KT-621 Dose 2
  • Experimental: Group 3: KT-621 Dose 3
  • Placebo Comparator: Group 4: Placebo

Primary Outcome Measure

Change from baseline in pre-bronchodilator FEV1 [ Time Frame: From baseline to Week 12 ]

Central Contacts

Locations (20)

FacilityCityStateZIPSite coordinators
Kymera Investigative SiteLong BeachCalifornia90815-
Kymera Investigative SiteNorthridgeCalifornia91324-
Kymera Investigative SiteReddingCalifornia96001-
Kymera Investigative SiteUplandCalifornia91786-
Kymera Investigative SiteLoxahatchee GrovesFlorida33470-
Kymera Investigative SiteMiamiFlorida33126-
Kymera Investigative SiteMiamiFlorida33173-
Kymera Investigative SiteTampaFlorida33607-
Kymera Investigative SiteEast PointGeorgia30344-
Kymera Investigative SiteIowa CityIowa52242-
Kymera Investigative SiteChapel HillNorth Carolina27517-
Kymera Investigative SiteToledoOhio43617-
Kymera Investigative SiteEdmondOklahoma73034-
Kymera Investigative SiteClackamasOregon97015-
Kymera Investigative SitePittsburghPennsylvania15241-
Kymera Investigative SiteNorth CharlestonSouth Carolina29406-
Kymera Investigative SiteRock HillSouth Carolina29732-
Kymera Investigative SiteChattanoogaTennessee37403-
Kymera Investigative SiteDallasTexas75209-
Kymera Investigative SiteMcKinneyTexas75069-

Find similar trials in Long Beach, CA

By research site
Kymera Investigative Site· Long Beach, CAKymera Investigative Site· Northridge, CAKymera Investigative Site· Redding, CAKymera Investigative Site· Upland, CAKymera Investigative Site· Loxahatchee Groves, FLKymera Investigative Site· Miami, FL

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