Paid Clinical Trials in North Carolina

North Carolina has 2,930 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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2,930 clinical trials

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A Study of Orelabrutinib in Patients With Primary Progressive Multiple Sclerosis

for Multiple Sclerosis (MS) Primary Progressive

11 locations incl. Pheonix

Sponsor: Zenas BioPharma (USA), LLC

Sex: All·Age: 18 - 60

Code: NCT07067463·Phase 3·Recruiting

Apply to this trial

A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight and Type 2 Diabetes

for Obesity or Overweight

Drug: Enicepatide

28 locations incl. Guntersville

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT07351058·Phase 3·Recruiting

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PODOMOUNT-Basket, a Study to Test Whether BI 764198 Helps Adults and Adolescents With Different Types of Kidney Disease

for Proteinuric Kidney Diseases

25 locations incl. Huntsville

Sponsor: Boehringer Ingelheim

Sex: All·Age: 12+

Code: NCT07355296·Phase 2·Recruiting

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Piloting a Generative Artificial Intelligence Chatbot in a Mobile Weight Loss Program

for Overweight and/or Obesity

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 39·Accepts healthy volunteers

Code: NCT07534254·Recruiting

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Pilot Trial for WounDx™ Clinical Decision Support Tool

for Wounds

5 locations incl. Birmingham

Sponsor: Henry M. Jackson Foundation for the Advancement of Military Medicine

Sex: All·Age: 18 - 65

Code: NCT06921707·Recruiting

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Dose Ranging Study of ORKA-002 in Patients With Moderate-to-Severe Plaque Psoriasis

for Plaque Psoriasis

22 locations incl. Birmingham

Sponsor: Oruka Therapeutics, Inc.

Sex: All·Age: 18 - 79

Code: NCT07474792·Phase 2·Recruiting

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A Study to Describe the Real-world Effectiveness, Safety and Patterns of Use of Dupilumab in Patients With Chronic Spontaneous Urticaria

for Chronic Spontaneous Urticaria

Drug: Dupilumab

1 location in Wilmington

Sponsor: Sanofi

Sex: All·Age: 12+

Code: NCT07316114·Recruiting

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Comparing Over the Counter Pain Medicines for Discomfort in Crohn's Disease (AVID-CD)

for Crohn's Disease (CD)

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: Female·Age: 18 - 44

Code: NCT07337902·Recruiting

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Preoperative Chemotherapy, Pembrolizumab and Low or High Dose RADiation in an Expansion Cohort of Node(+), Triple Negative Breast Cancer

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07276880·Phase 2·Recruiting

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A Phase 3 Trial to Compare IV BCV Versus IV CDV for Treatment of Adenovirus Infection After Allo-HCT

for Adenovirus Infections

26 locations incl. Phoenix

Sponsor: SymBio Pharmaceuticals

Sex: All·Age: 2 Months+

Code: NCT07387367·Phase 3·Recruiting

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The Use of p48/64 MW HPC Flow Modulation Device in the Treatment of Wide-necked Intracranial Aneurysms

for Hemorrhagic Stroke

17 locations incl. Phoenix

Sponsor: phenox Inc.

Sex: All·Age: 18+

Code: NCT07143019·Recruiting

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Resilience Enhancement Using Electronic Frailty Index-Directed Care Pathway

for Cancer

2 locations incl. Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 65+

Code: NCT07175376·Recruiting

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A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)

for Non-small Cell Lung Cancer (NSCLC)

Drug: Durvalumab

38 locations incl. Daphne

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07361497·Phase 3·Recruiting

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Local Radiofrequency Ablation Plus External Beam Radiation for the Treatment of Painful Thoracic and Lumbar Spine Tumors

for Thoracic Neoplasms

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07479199·Recruiting

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Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-related Macular Degeneration (AQUARIUS)

for Neovascular Age-Related Macular Degeneration (nAMD)

46 locations incl. Phoenix

Sponsor: Adverum Biotechnologies, Inc.

Sex: All·Age: 50+

Code: NCT07482176·Phase 3·Recruiting

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A Phase 3 Efficacy and Safety Study of HBS-301 in Participants With Idiopathic Hypersomnia (IH)

for Idiopathic Hypersomnia

12 locations incl. Santa Monica

Sponsor: Harmony Biosciences Management, Inc.

Sex: All·Age: 18+

Code: NCT07500090·Phase 3·Recruiting

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A Long-term Follow-up Study of Patients With ARD103 CAR-T Cell Therapies

for Acute Myeloid Leukemia, in Relapse

3 locations incl. Charlotte

Sponsor: ARCE Therapeutics, Inc.

Sex: All·Age: All ages

Code: NCT06906380·Not Yet Recruiting

A Study of MUC16-Directed Antibody Drug Conjugate HWK-016 in Participants With Advanced Solid Tumors.

for PROC

12 locations incl. Little Rock

Sponsor: Whitehawk Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07470853·Phase 1·Recruiting

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A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204)

for Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma

Drug: Nivolumab

34 locations incl. Phoenix

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07221149·Phase 2, Phase 3·Recruiting

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MIST (Metabolic Intervention With Semaglutide and THR-β Therapy) Trial

for Adult Obesity

Drug: Semaglutide

15 locations incl. Birmingham

Sponsor: Eccogene

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT07505303·Phase 2·Not Yet Recruiting

IL-17 Blockade to Decrease irAEs (REPLAY)

for Metastatic Melanoma

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07237594·Phase 1·Recruiting

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A Study to Evaluate the Efficacy of Pumitamig Versus Pembrolizumab in Participants With Previously Untreated Advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%. (ROSETTA Lung-202)

for Non-Small Cell Lung Cancer (NSCLC)

Drug: Pumitamig

40 locations incl. Daphne

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07361510·Phase 3·Recruiting

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Validation of a Platelet Proteomic Assay for Diagnosing and Monitoring Prostate Cancer

for Prostate Cancer (Diagnosis)

1 location in Durham

Sponsor: Duke University

Sex: Male·Age: 40+

Code: NCT07144228·Recruiting

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Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cartilage Lesions and Osteoarthritis

for Knee Cartilage Defects

17 locations incl. Birmingham

Sponsor: Medipost, Inc.

Sex: All·Age: 18 - 75

Code: NCT07339111·Phase 3·Recruiting

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Ketamine add-on Therapy for Established Status Epilepticus Treatment Trial (KESETT)

for Status Epilepticus

52 locations incl. Tucson

Sponsor: University of Virginia

Sex: All·Age: 1+

Code: NCT06907173·Phase 3·Recruiting

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A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer

for CRC (Colorectal Cancer)

Drug: Bevacizumab

80 locations incl. Chandler

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT07284849·Phase 3·Recruiting

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A Study of Nipocalimab in Adults With Moderate to Severe Systemic Lupus Erythematosus

for Lupus Erythematosus, Systemic

Drug: Nipocalimab

29 locations incl. Beverly Hills

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18 - 75

Code: NCT07438496·Phase 3·Recruiting

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A Study to Investigate OCS Tapering in Adult Participants With Generalized Myasthenia Gravis Treated With Ravulizumab

for Generalized Myasthenia Gravis

5 locations incl. Chicago

Sponsor: Alexion Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT07221838·Phase 4·Recruiting

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Metformin Hydrochloride in Combination With Standard of Care Systemic Therapy in Previously Untreated Advanced Unresectable or Metastatic Soft Tissue Sarcoma

for Sarcoma Metastatic

2 locations incl. Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT07291297·Phase 2·Recruiting

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TOUCH® CMC 1 New Enrollment US Study

for Osteoarthritis Thumb

4 locations incl. Aurora

Sponsor: Keri Medical SA

Sex: All·Age: 22+

Code: NCT07405983·Recruiting

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Efficacy and Safety of Ribupatide (KAI-9531) Administered Once Weekly in Participants Living With Obesity Who Do Not Have Diabetes

for Obesity

35 locations incl. Mesa

Sponsor: Kailera

Sex: All·Age: 18+

Code: NCT07458269·Phase 2·Enrolling By Invitation

Intra-abdominal Pressure (IAP) During PFA Treatment of A-fib/ A-Flutter

for Intra-Abdominal Hypertension

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06876896·Recruiting

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A Study Exploring Changes in a Variety of Biomarkers Following Dosing With MT1988 in Participants at Clinical High Risk for Psychosis

for Clinical High Risk for Psychosis (CHR)

15 locations incl. Irvine

Sponsor: Monument Therapeutics Limited

Sex: All·Age: 17 - 30

Code: NCT07226895·Phase 1, Phase 2·Recruiting

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LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2

for Pulmonary Hypertension Associated With HFpEF

18 locations incl. Alexander City

Sponsor: Tenax Therapeutics, Inc.

Sex: All·Age: 18 - 85

Code: NCT07288398·Phase 3·Recruiting

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GORE® TAG® Thoracic Branch Endoprosthesis Zone 0/1 Post-Approval Study

for Aortic Arch Dissection

6 locations incl. Gainesville

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT07166133·Recruiting

Apply to this trial

Automated Applanation Tonometry - Updated

for Glaucoma

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07298356·Recruiting

Apply to this trial

A Mobile Text Approach to Measurement and Feedback for Wraparound Care Coordination

for Mental Health Services

1 location in Durham

Sponsor: 3-C Institute for Social Development

Sex: All·Age: 8+

Code: NCT07300930·Not Yet Recruiting

Adolescent Mental Health Parenting Program for Child-Adult Relationship Enhancement

for Adolescent Behavior

2 locations incl. Cary

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT07303062·Not Yet Recruiting

Tirzepatide in Idiopathic Intracranial Hypertension Trial

for Idiopathic Intracranial Hypertension (IIH)

Drug: Tirzepatide

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 60

Code: NCT07191873·Phase 4·Not Yet Recruiting

A Usability Study of a Multi-channel ECG Monitoring Device

for Healthy Adult Participants

1 location in New London

Sponsor: Wearlinq

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07388355·Not Yet Recruiting