MIST (Metabolic Intervention With Semaglutide and THR-β Therapy) Trial

Part of paid clinical trials in Birmingham, Alabama.

Sponsor
Eccogene
Study ID
NCT07505303
Phase
PHASE2
Status
Not Yet Recruiting

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Conditions

  • Adult Obesity
  • Weight Management

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Accepted

Interventions

  • ECC4703 — DRUG
    orally QD
  • Placebo — DRUG
    orally QD
  • Semaglutide — DRUG
    SC once weekly

Study Details

The primary objective of this trial is to evaluate the effect of oral ECC4703 on body weight reduction and in a sub-study on liver fat content as assessed by change in magnetic resonance imaging proton density fat fraction (MRI-PDFF) at Week 20.

Key Dates

Start date
Mar 13, 2026
Status verified
Feb 2026
Primary completion
Nov 20, 2026
Completion
Nov 20, 2026

Study Design

Enrollment
160 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Arm 1: ECC4703 + semaglutide
    ECC4703 orally QD + semaglutide SC once weekly
  • Placebo Comparator: Arm 2: Placebo + semaglutide
    Placebo orally QD + semaglutide SC once weekly

Primary Outcome Measure

Percentage Change in Body Weight from Baseline (Week 9) to Week 20 [ Time Frame: Baseline (Week 9) to Week 20 ]

Central Contacts

Locations (15)

FacilityCityStateZIPSite coordinators
Central Research Associates - Flourish - PPDSBirminghamAlabama35205-
Anaheim Clinical Trials LLC - Anaheim - CenExel - PPDSAnaheimCalifornia92081-
Collaborative Neuroscience Network - Los Alamitos- CenExel - PPDSLos AlamitosCalifornia90720-
AES - DRS - Optimal Research Florida - MelbourneMelbourneFlorida32934-
ForCare Clinical Research - CenExel FCR - PPDSTampaFlorida33613-
Atlanta Center for Medical Research - CenExel ACMR - PPDSAtlantaGeorgia30331-
iResearch Atlanta - CenExel - PPDSDecaturGeorgia30030-
AES - DRS - Synexus Clinical Research US, Inc. - Richfield - MinneapolisRichfieldMinnesota55423-
Velocity Clinical Research (3345 N 107th St) - Omaha - Nebraska - PPDSOmahaNebraska68134-
Velocity Clinical Research - Durham - PPDSDurhamNorth Carolina27701-
Velocity Clinical Research - Cincinnati (Springdale) - Ohio - PPDSCincinnatiOhio45246-
Velocity Clinical Research - Providence - PPDSEast GreenwichRhode Island02818-
Velocity Clinical Research - Dallas - PPDSDallasTexas75230-
AES - DRS - Synexus Clinical Research US, Inc. - San AntonioSan AntonioTexas78229-
Flourish Research - San Antonio - PPDSSan AntonioTexas78229-

Find similar trials in Birmingham, AL

By research site
Central Research Associates - Flourish - PPDS· Birmingham, ALAnaheim Clinical Trials LLC - Anaheim - CenExel - PPDS· Anaheim, CACollaborative Neuroscience Network - Los Alamitos- CenExel - PPDS· Los Alamitos, CAAES - DRS - Optimal Research Florida - Melbourne· Melbourne, FLForCare Clinical Research - CenExel FCR - PPDS· Tampa, FLAtlanta Center for Medical Research - CenExel ACMR - PPDS· Atlanta, GA

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