How a Single Workout Affects Gut Bugs in Women With Different Fitness Levels and Body Types

Part of paid clinical trials in Washington D.C., District of Columbia.

Sponsor
George Washington University
Study ID
NCT06691100
Status
Recruiting
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Conditions

  • Exercise
  • Gut Microbiome
  • Gut Microbiota
  • Health
  • Metabolome
  • Obesity
  • Weight Management
  • Women

Eligibility Criteria

Sex
FEMALE
Age
21 Years - 40 Years
Healthy Volunteers
Accepted

Interventions

  • Aerobic Exercise — BEHAVIORAL
    30-minute exercise bout in a cycle ergometer at 60 to 70% of the Heart Rate Reserve (HRR) and corresponding power (watts).

Study Details

This study aims to elucidate the differences in the gut microbiome functional activity and metabolome in adult premenopausal women with distinctive fitness levels and BMIs (with obesity, w/o obesity). The specific aims are as follows: * Aim 1: To examine the effects of acute aerobic exercise at 60-70% heart rate reserve (HRRmax) for 30 minutes bout on changes in the abundance of SCFA-producing bacteria and their functional downstream metabolic activity. * Aim 2: To examine the effects of acute aerobic exercise at 60-70% HRRmax 30-minute bout on changes in GM-released SCFA concentrations in stool and plasmatic metabolome.

Key Dates

Start date
Oct 16, 2024
Status verified
Jul 2025
Primary completion
Jun 1, 2027
Completion
Oct 16, 2027

Study Design

Enrollment
40 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION

Arms

  • Experimental: Intervention
    30-minute exercise bout in a cycle ergometer at 60 to 70% of the Heart Rate Reserve (HRR) and corresponding power (watts).

Primary Outcome Measure

Gut Microbiome Composition [ Time Frame: Before the exercise intervention and immediately after the intervention ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Milken Institute School of Public Health, The George Washington UniversityWashington D.C.District of Columbia20037
Carmen Ortega-Santos, PhD, RD
[email protected]
202-994-2757

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Milken Institute School of Public Health, The George Washington University· Washington D.C., DC

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