Paid Clinical Trials in North Carolina

North Carolina has 2,944 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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2,944 clinical trials

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Cenobamate Open-Label Extension Study for YKP3089C025

for Primary Generalized Tonic Clonic Seizures in the Setting of Idiopathic Generalized Epilepsy

Drug: Cenobamate

16 locations incl. La Jolla

Sponsor: SK Life Science, Inc.

Sex: All·Age: 12+

Code: NCT03961568·Phase 3·Enrolling By Invitation

Pan Tumor Rollover Study

for Cancer

59 locations incl. Huntsville

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT03899155·Phase 2·Recruiting

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Evaluation of Stool Based Markers for the Early Detection of Colorectal Cancers and Adenomas

for Colonic Neoplasms

11 locations incl. Los Angeles

Sponsor: University of Michigan Rogel Cancer Center

Sex: All·Age: 18+

Code: NCT00843375·Recruiting

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Radiographic and Clinical Evaluation of Surgical Treatment for Cervical Deformity: A Multi-Center Study 2.0

for Cervical Deformity

16 locations incl. La Jolla

Sponsor: International Spine Study Group Foundation

Sex: All·Age: 18+

Code: NCT04194996·Recruiting

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SUNOSI® (Solriamfetol) Pregnancy Registry

for Narcolepsy

Drug: Solriamfetol

2 locations incl. Morrisville

Sponsor: Axsome Therapeutics, Inc.

Sex: Female·Age: All ages

Code: NCT06413420·Recruiting

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A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma

for Glioblastoma

42 locations incl. Birmingham

Sponsor: Global Coalition for Adaptive Research

Sex: All·Age: 18+

Code: NCT03970447·Phase 2, Phase 3·Recruiting

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GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study

for Stroke

45 locations incl. Tucson

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18 - 70

Code: NCT03821129·Recruiting

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Closed Loop DBS Implanted RC+S Study

for Parkinson Disease

1 location in Durham

Sponsor: Dennis Turner, M.D.

Sex: All·Age: 18 - 75

Code: NCT03815656·Enrolling By Invitation

Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions

for Metastatic Uveal Melanoma

12 locations incl. Los Angeles

Sponsor: IDEAYA Biosciences

Sex: All·Age: 18+

Code: NCT03947385·Phase 1, Phase 2·Recruiting

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Tumor Subtypes in Subjects on FOLFIRINOX With Non-Metastatic Pancreatic Cancer

for Pancreatic Ductal Adenocarcinoma (PDAC)

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18 - 99

Code: NCT03977233·Phase 2·Recruiting

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A Study to Evaluate Efficacy and Safety of Perampanel Administered as an Adjunctive Therapy in Pediatric Participants With Childhood Epilepsy

for Pediatric Epileptic Syndrome

22 locations incl. Phoenix

Sponsor: Eisai Inc.

Sex: All·Age: 1 Month - 18

Code: NCT04015141·Phase 2·Recruiting

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Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study

for Lower Respiratory Tract Infection

49 locations incl. Duarte

Sponsor: Ansun Biopharma, Inc.

Sex: All·Age: All ages

Code: NCT03808922·Phase 3·Recruiting

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Treatment of Radiation and Cisplatin Induced Toxicities with Tempol

for Mucositis

9 locations incl. La Jolla

Sponsor: Matrix Biomed, Inc.

Sex: All·Age: 18+

Code: NCT03480971·Phase 2·Recruiting

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Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

for Bladder Adenocarcinoma

Drug: Cabozantinib

579 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT03866382·Phase 2·Recruiting

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Inotuzumab Ozogamicin and Blinatumomab With or Without Ponatinib in Treating Patients With Newly Diagnosed, Recurrent, or Refractory CD22-Positive B-Lineage Acute Lymphoblastic Leukemia

for B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative

275 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT03739814·Phase 2·Recruiting

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Cereset Research Exploratory Study

for Neurological Diseases or Conditions

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 11+

Code: NCT03777267·Recruiting

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An Open-label Study to Assess Safety and Efficacy of SZC in Paediatric Patients With Hyperkalaemia

for Hyperkalaemia

14 locations incl. Birmingham

Sponsor: AstraZeneca

Sex: All·Age: 0 - 18

Code: NCT03813407·Phase 3·Recruiting

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Long-Term Real-World Outcomes Study on Patients Implanted With a Neurostimulator

for Chronic Pain

30 locations incl. Phoenix

Sponsor: Abbott Medical Devices

Sex: All·Age: 18+

Code: NCT03876054·Recruiting

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Chemotherapy Before Surgery and Radiation Therapy or Surgery and Radiation Therapy Alone in Treating Patients With Nasal and Paranasal Sinus Cancer That Can Be Removed by Surgery

for Stage III Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v6 and v7

140 locations incl. Tucson

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT03493425·Phase 2·Recruiting

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Deep Brain Stimulation (DBS) Retrospective Outcomes Study

for Parkinson Disease

9 locations incl. Phoenix

Sponsor: Boston Scientific Corporation

Sex: All·Age: All ages

Code: NCT03664609·Recruiting

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Dose-escalation and Dose-expansion Study of Safety of Azer-cel (PBCAR0191) in Participants With Relapsed/Refractory (r/r) Non-Hodgkin Lymphoma (NHL) and r/r B-cell Acute Lymphoblastic Leukemia (B-ALL)

for Non-Hodgkin Lymphoma

18 locations incl. Gilbert

Sponsor: Imugene Limited

Sex: All·Age: 18+

Code: NCT03666000·Phase 1·Recruiting

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Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Tuspetinib (HM43239) in Patients With Relapsed or Refractory Acute Myeloid Leukemia

for Leukemia, Myeloid, Acute

Drug: Tuspetinib

15 locations incl. Birmingham

Sponsor: Aptose Biosciences Inc.

Sex: All·Age: 18+

Code: NCT03850574·Phase 1, Phase 2·Recruiting

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Study of CAR T-Cells Targeting the GD2 With IL-15+iCaspase9 for Relapsed/Refractory Neuroblastoma or Relapsed/Refractory Osteosarcoma

for Neuroblastoma

2 locations incl. Atlanta

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18 Months+

Code: NCT03721068·Phase 1·Recruiting

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Preventing Alzheimer's With Cognitive Training

for Age-related Cognitive Decline

7 locations incl. Gainesville

Sponsor: University of South Florida

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT03848312·Phase 3·Recruiting

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Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

for Previously Treated Non-Small Cell Lung Cancer

1229 locations incl. Birmingham

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT03851445·Phase 2, Phase 3·Recruiting

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Synergistic Activity of Human Milk Nutrients and Infant Cognition

for Breastfeeding, Exclusive

1 location in Kannapolis

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 3 Months - 35·Accepts healthy volunteers

Code: NCT03838536·Recruiting

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A Long-term Observational Study Evaluating Eteplirsen, Golodirsen, or Casimersen in Routine Clinical Practice

for Duchenne Muscular Dystrophy

20 locations incl. Little Rock

Sponsor: Sarepta Therapeutics, Inc.

Sex: Male·Age: All ages

Code: NCT06606340·Enrolling By Invitation

Multisite Inventory of Neonatal-Perinatal Interventions (MINI) Minimum Dataset

for Infant, Extremely Premature

37 locations incl. Birmingham

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: 0 - 1

Code: NCT05685745·Recruiting

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Study of Individuals Affected With Hypoplasminogenemia

for Plasminogen Deficiency

13 locations incl. Birmingham

Sponsor: Indiana Hemophilia &Thrombosis Center, Inc.

Sex: All·Age: All ages

Code: NCT03797495·Recruiting

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Anesthetics and Analgesics in Children

for Anesthesia

11 locations incl. Stanford

Sponsor: Chi Dang Hornik

Sex: All·Age: 0 - 17

Code: NCT03427736·Recruiting

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Parent and Infant Inter(X)Action Intervention (PIXI)

for Fragile X Syndrome

1 location in Research Triangle Park

Sponsor: RTI International

Sex: All·Age: Up to 99·Accepts healthy volunteers

Code: NCT03836300·Enrolling By Invitation

Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases

for Brain Metastases

73 locations incl. Tucson

Sponsor: Canadian Cancer Trials Group

Sex: All·Age: 18+

Code: NCT03550391·Phase 3·Recruiting

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Harnessing Analysis RNA Expression and Molecular Subtype to Optimize Novel TherapY MBCA

for Breast Cancer

2 locations incl. Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18 - 99

Code: NCT03769415·Recruiting

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Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections

for Pulmonary Invasive Fungal Infections

32 locations incl. Little Rock

Sponsor: Arkansas Children's Hospital Research Institute

Sex: All·Age: 120 Days - 21

Code: NCT03827694·Recruiting

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Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer

for Breast Cancer

451 locations incl. Fairbanks

Sponsor: Canadian Cancer Trials Group

Sex: Female·Age: 35+

Code: NCT03488693·Phase 3·Recruiting

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Early Check: Expanded Screening in Newborns

for Spinal Muscular Atrophy

1 location in Research Triangle Park

Sponsor: RTI International

Sex: All·Age: 1 Day - 31 Days·Accepts healthy volunteers

Code: NCT03655223·Enrolling By Invitation

Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants

for Lactating Women on Select DOI

20 locations incl. La Jolla

Sponsor: Duke University

Sex: All·Age: All ages

Code: NCT03511118·Recruiting

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Intraoperative OCT Guidance of Intraocular Surgery II

for Macular Holes

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 4 Weeks+·Accepts healthy volunteers

Code: NCT03713268·Recruiting

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A Phase 2 Study of Home Care Following Autologous Hematopoietic Stem Cell Transplantation

for Well-being of Caregivers (Caregiver Strain Index)

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 80

Code: NCT03667599·Recruiting

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Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA)

for Spinal Muscular Atrophy (SMA)

50 locations incl. Phoenix

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: All ages

Code: NCT04174157·Recruiting

Apply to this trial