Paid Clinical Trials in North Carolina

North Carolina has 2,944 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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2,944 clinical trials

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Prospective Multisite Study of Quality of Life in Pediatric Intestinal Failure

for Pediatric Intestinal Failure

11 locations incl. Birmingham

Sponsor: Boston Children's Hospital

Sex: All·Age: 6 Months - 25

Code: NCT04629014·Recruiting

Apply to this trial

Clinical Trial for Surgery of the Ulnar Nerve (SUN) at the Elbow

for Neuropathy Ulnar

10 locations incl. Atlanta

Sponsor: University of Michigan

Sex: All·Age: 18+

Code: NCT04254185·Recruiting

Apply to this trial

Global Utilization And Registry Database for Improved heArt preservatioN

for Heart Diseases

17 locations incl. Stanford

Sponsor: Paragonix Technologies

Sex: All·Age: All ages

Code: NCT04141605·Enrolling By Invitation

A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma

for Low Grade Astrocytoma

Drug: Selumetinib

124 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 2 - 21

Code: NCT04166409·Phase 3·Recruiting

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A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain

for Osteoarthritis, Knee

62 locations incl. Birmingham

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT05986292·Phase 2·Recruiting

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Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

for Intracerebral Hemorrhage

187 locations incl. Birmingham

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT03907046·Phase 3·Recruiting

Apply to this trial

Brief Cognitive Behavioral Therapy Replication Trial

for Suicide, Attempted

3 locations incl. Jacksonville

Sponsor: University of Utah

Sex: All·Age: 18+

Code: NCT03769259·Enrolling By Invitation

Can Intraosseous Antibiotics Improve the Results of Irrigation & Debridement and Prosthetic Retention for PJI?

for Joint Infection

10 locations incl. San Francisco

Sponsor: OrthoCarolina Research Institute, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT03713528·Phase 4·Enrolling By Invitation

Circulating Tumor DNA (ctDNA) in Locally Advanced Head and Neck Squamous Cell Carcinoma

for Head and Neck Neoplasm

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT04099290·Recruiting

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Prospective Measurement of Normal Venous Sinus Pressures

for Intracranial Venous Pressures

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18 - 60

Code: NCT03948971·Recruiting

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A Study of REGN5093 in Adult Patients With Mesenchymal Epithelial Transition Factor (MET)-Altered Advanced Non-Small Cell Lung Cancer

for NSCLC

18 locations incl. Birmingham

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT04077099·Phase 1, Phase 2·Recruiting

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Post Approval Study for Treatment of Drug-resistant Adult and Pediatric Primary FSGS Using the LIPOSORBER® LA-15 System

for Focal Segmental Glomerulosclerosis

10 locations incl. Loma Linda

Sponsor: Kaneka Medical America LLC

Sex: All·Age: Up to 75

Code: NCT04065438·Recruiting

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Pelvic and Acetabular Fracture: A Prospective Observational Study

for Pelvic Fracture

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT04615104·Recruiting

Apply to this trial

Reproductive Axis Maturation in the Early Post-Menarchal Years

for Reproductive Physiological Processes

1 location in Research Triangle Park

Sponsor: National Institute of Environmental Health Sciences (NIEHS)

Sex: Female·Age: 8 - 65·Accepts healthy volunteers

Code: NCT03986021·Recruiting

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Best Available Therapy Versus Autologous Hematopoietic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS)

for Relapsing Multiple Sclerosis

22 locations incl. Palo Alto

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 55

Code: NCT04047628·Phase 3·Recruiting

Apply to this trial

Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma

for Cutaneous Melanoma, Stage II

130 locations incl. Mobile

Sponsor: Melanoma and Skin Cancer Trials Limited

Sex: All·Age: 18+

Code: NCT03860883·Recruiting

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Self Reported Pain in Women While Undergoing Treatment for Non-metastatic Breast Cancer

for Breast

2 locations incl. Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: Female·Age: 18+

Code: NCT04174742·Recruiting

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A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis

for Myelofibrosis

32 locations incl. Birmingham

Sponsor: Sumitomo Pharma America, Inc.

Sex: All·Age: 18+

Code: NCT04176198·Phase 1, Phase 2·Recruiting

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Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

for Atrial Fibrillation

51 locations incl. Little Rock

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18+

Code: NCT04045665·Phase 3·Recruiting

Apply to this trial

Duke APOL1 Research Biorepository

for End Stage Kidney Disease

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04160507·Recruiting

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Prophylactic Reinforcement of Ventral Abdominal Incisions Trial

for Open Midline Laparotomy

31 locations incl. Phoenix

Sponsor: C. R. Bard

Sex: All·Age: 18+

Code: NCT03911700·Recruiting

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Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

for Tricuspid Regurgitation

73 locations incl. Phoenix

Sponsor: Edwards Lifesciences

Sex: All·Age: 18+

Code: NCT04097145·Recruiting

Apply to this trial

Medtronic Cardiac Surgery PMCF Registry

for Valve Disease, Heart

11 locations incl. Marietta

Sponsor: Medtronic Cardiac Surgery

Sex: All·Age: All ages

Code: NCT04073420·Recruiting

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Registry of Participants With Generalized Myasthenia Gravis Treated With Alexion C5 Inhibition Therapies (C5ITs)

for Generalized Myasthenia Gravis

32 locations incl. Birmingham

Sponsor: Alexion Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT04202341·Recruiting

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A Prospective Registry of Pediatric Cellular Therapy Patients at Risk for Endothelial Dysfunction, Sinusoidal Obstruction Syndrome and/or Multi-Organ Dysfunction Syndrome (MODS).

for Hematopoietic Cell Transplantation

3 locations incl. Rochester

Sponsor: Duke University

Sex: All·Age: 0 - 26

Code: NCT05090345·Recruiting

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Addressing Neuromuscular Deficits for Improved Outcomes in Ankle Rehabilitation

for Ankle Sprains

2 locations incl. Lexington

Sponsor: Phillip Gribble

Sex: All·Age: 18 - 44

Code: NCT03663361·Recruiting

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A Study of Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation

for Acute Myeloid Leukemia

Drug: Revumenib

22 locations incl. Duarte

Sponsor: Syndax Pharmaceuticals

Sex: All·Age: 30 Days+

Code: NCT04065399·Phase 1, Phase 2·Recruiting

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Muscle Fiber Fragments for Improved Function of Rotator Cuff Musculature Following Rotator Cuff Repair

for Rotator Cuff

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 40 - 80

Code: NCT03752034·Recruiting

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Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy

for B Acute Lymphoblastic Leukemia

203 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 365 Days - 25

Code: NCT03959085·Phase 3·Recruiting

Apply to this trial

Carboplatin or Olaparib for BRcA Deficient Prostate Cancer

for Metastatic Castrate Resistant Prostate Cancer

18 locations incl. West Los Angeles

Sponsor: VA Office of Research and Development

Sex: Male·Age: 18+

Code: NCT04038502·Phase 2·Recruiting

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A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

for Treatment Resistant Depression

101 locations incl. Birmingham

Sponsor: LivaNova

Sex: All·Age: 18+

Code: NCT03887715·Recruiting

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Role of Ablative Radiotherapy in the Management of Metastatic Disease: A Patient Data Registry

for Oligometastasis

5 locations incl. Cary

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT04085029·Recruiting

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A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension

for PAH

Drug: Ralinepag

48 locations incl. Phoenix

Sponsor: United Therapeutics

Sex: All·Age: 18+

Code: NCT03683186·Phase 3·Enrolling By Invitation

Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer

for Colorectal Cancer

146 locations incl. Millville

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 60+

Code: NCT03998202·Recruiting

Apply to this trial

CD30 CAR for Relapsed/Refractory CD30+ T Cell Lymphoma

for Peripheral T Cell Lymphoma

2 locations incl. Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18 - 99

Code: NCT04083495·Phase 2·Recruiting

Apply to this trial

Stroke Thrombectomy and Aneurysm Registry

for Stroke

54 locations incl. Birmingham

Sponsor: Medical University of South Carolina

Sex: All·Age: 1 - 120

Code: NCT04994756·Recruiting

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Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma

for Smoldering Plasma Cell Myeloma

Drug: Daratumumab

741 locations incl. Birmingham

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT03937635·Phase 3·Recruiting

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Orthognathic Speech Pathology: Phonetic Contrasts of Patients With Dental Discrepancies Pre- and Post-Treatment Analyses

for Dentofacial Abnormalities

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 15 - 40

Code: NCT04117360·Recruiting

Apply to this trial

Kidney Precision Medicine Project

for Acute Kidney Failure

13 locations incl. Tucson

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18+

Code: NCT04334707·Recruiting

Apply to this trial

Suvorexant: A Dual Orexin Receptor Antagonist for Treating Sleep Disturbance in Posttraumatic Stress

for Sleep Initiation and Maintenance Disorders

4 locations incl. Long Beach

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 75

Code: NCT03642028·Phase 4·Recruiting

Apply to this trial