Duke APOL1 Research Biorepository

Part of paid clinical trials in Durham, North Carolina.

Sponsor
Duke University
Study ID
NCT04160507
Status
Recruiting
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Conditions

  • End Stage Kidney Disease

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Biorepository — OTHER
    To collect and store biological samples (whole blood and urine), along with relevant medical information, from adult inpatients and outpatients. Buffy coats will also be received from H3Africa Kidney Disease Research Network.

Study Details

The Duke ApoL1 Nephropathy Biorepository aims to address needs within non-diabetic kidney failure research by utilizing existing and, when necessary, developing new infrastructure to support the consent of patients and the collection of dedicated samples for ApoL1 Nephropathy biorepository. The mutations in ApoL1 gene that are strongly associated with kidney disease are only present in individuals of recent African ancestry (i.e., black people). Caucasians do not have these ApoL1 mutations nor the associated kidney disease. Therefore, majority of subjects recruited for this study will be self-identified African Americans, Afro-Caribbean and other black individual. Study subjects will include individuals with end stage kidney disease and those without any clinical evidence of kidney disease. Additionally, healthy black adults with no known history of kidney disease will be recruited as controls in this study because they are the only group that can fill this role.

Key Dates

Start date
Dec 13, 2019
Status verified
Mar 2025
Primary completion
Nov 15, 2026
Completion
Nov 15, 2026

Study Design

Enrollment
200 participants (estimated)

Arms

  • Arm: Healthy black adults 50 and over
    Healthy black adults age 50 and over with no known history of kidney disease will be recruited as controls in this study.
  • Arm: black adult cases with non-diabetic nephropathy
    black adult cases with non-diabetic nephropathy

Primary Outcome Measure

Biorepository [ Time Frame: 5 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Duke University Medical CenterDurhamNorth Carolina27705
Maurice W Smith, M.A.
[email protected]
919-613-1386
Opeyemi Olabisi, MD (PRINCIPAL_INVESTIGATOR)

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Duke University Medical Center· Durham, NC

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