Preventing Alzheimer's With Cognitive Training

Part of paid clinical trials in Gainesville, Florida.

Sponsor
University of South Florida
Study ID
NCT03848312
Phase
PHASE3
Status
Recruiting
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Conditions

  • Age-related Cognitive Decline
  • Alzheimer's Disease and Related Dementias

Eligibility Criteria

Sex
ALL
Age
65 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Cognitive Training — BEHAVIORAL
    Participants will be completing a total of 45 computerized sessions.
  • Computerized Cognitive Stimulation — BEHAVIORAL
    Participants will be completing a total of 45 computerized cognitive stimulation sessions.

Study Details

Dementia is the most expensive medical condition in the US and increases in prevalence with age. More than 5 million Americans have Alzheimer's disease, the most common form of dementia. Mild cognitive impairment is a transitional stage between normal cognitive aging and Alzheimer's disease or another type of dementia, and is indicative of higher risk for dementia. In addition to the obvious health and quality-of-life ramifications of dementia, there are high direct (e.g., subsidizing residential care needs) and indirect (e.g., lost productivity of family caregivers) economic costs. Implementing interventions to prevent MCI and dementia among older adults is of critical importance to health and maintained quality-of-life for millions of Americans. Recent data analyses from the Advanced Cognitive Training in Vital Elderly study (ACTIVE) indicate that a specific cognitive intervention, speed of processing training (SPT), significantly delays the incidence of cognitive impairment across 10 years. The primary contribution of the proposed research will be the determination of whether this cognitive training technique successfully delays the onset of clinically defined MCI or dementia across three years.

Key Dates

Start date
Feb 19, 2019
Status verified
Sep 2024
Primary completion
Jan 31, 2026
Completion
Jan 31, 2026

Study Design

Enrollment
7,600 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Experimental: Computerized Cognitive Training
    Participants will complete computerized cognitive training.
  • Active Comparator: Computerized Cognitive Stimulation
    Participants will complete cognitively-stimulating computer activities.

Primary Outcome Measure

Incidence of mild cognitive impairment or dementia [ Time Frame: Three years ]

Central Contacts

Locations (7)

FacilityCityStateZIPSite coordinators
University of FloridaGainesvilleFlorida32611-
University of FloridaJacksonvilleFlorida32209-
University of North FloridaJacksonvilleFlorida32224-
The Roskamp InstituteSarasotaFlorida34243
Dorothy St. Pierre
[email protected]
941-500-4447
Laila Abdullah, PhD (PRINCIPAL_INVESTIGATOR)
University of South FloridaTampaFlorida33620
Hope Clark-Bell
[email protected]
813-974-6703
Jennifer L O'Brien, PhD (PRINCIPAL_INVESTIGATOR)
Duke HealthDurhamNorth Carolina27705
Marianne Chanti-Ketterl, PhD
[email protected]
919-668-3154
Brenda Plassman, PhD (PRINCIPAL_INVESTIGATOR)
Clemson University Institute for Engaged AgingSenecaSouth Carolina29672
Kimberly Scoles
[email protected]
864-916-6220
Lesley A Ross, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Gainesville, FL

By research site
University of Florida· Gainesville, FLUniversity of Florida· Jacksonville, FLUniversity of North Florida· Jacksonville, FLThe Roskamp Institute· Sarasota, FLUniversity of South Florida· Tampa, FLDuke Health· Durham, NC

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