Paid Clinical Trials in North Carolina

North Carolina has 2,930 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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2,930 clinical trials

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Long-Term Safety Study of Deucravacitinib Versus Ustekinumab in Participants With Psoriasis (PRAGMATYK)

for Plaque Psoriasis

Drug: Deucravacitinib

122 locations incl. Birmingham

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 40+

Code: NCT07116967·Phase 3·Recruiting

Apply to this trial

Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease

for High Risk Cardiovascular Disease

Drug: Zilebesiran

247 locations incl. Birmingham

Sponsor: Alnylam Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07181109·Phase 3·Recruiting

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Study to Evaluate the Efficacy and Safety of VQW-765 for the On-Demand Treatment of Social Anxiety Disorder

for Social Anxiety Disorder (SAD)

30 locations incl. Phoenix

Sponsor: Vanda Pharmaceuticals

Sex: All·Age: 18 - 65

Code: NCT07221578·Phase 3·Recruiting

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Affect-based Impulsivity in Borderline Personality Disorder

for Borderline Personality Disorder (BPD)

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT06880640·Recruiting

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Pilot of Continuous Glucose Monitor-Augmented Food Is Medicine

for Nutrition

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT07148713·Recruiting

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Studying the Presence of CFRD Complications With Thoughtful Recruitment (SPeCTRuM)

for Cystic Fibrosis (CF)

18 locations incl. Birmingham

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 12+

Code: NCT06837181·Recruiting

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Comparative Efficacy of Organizational Skills Training (OST) and Mindfulness-Based Intervention (MBI)

for ADHD

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 13 - 17·Accepts healthy volunteers

Code: NCT07089745·Recruiting

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DESTINY-PANTUMOUR04

for Adenocarcinoma (NOS)

17 locations incl. Birmingham

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT07124000·Recruiting

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ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab

for Anatomic Stage I Breast Cancer AJCC v8

652 locations incl. Phoenix

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT06876714·Phase 3·Recruiting

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MAPS PrEP Van Study

for HIV Infection

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06908252·Phase 4·Recruiting

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Repurposing Tilmanocept for Cardiac Sarcoidosis

for Cardiac Sarcoidosis

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07159074·Phase 2·Recruiting

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A Study of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease

for Alzheimers Disease

Drug: Trontinemab

35 locations incl. Birmingham

Sponsor: Hoffmann-La Roche

Sex: All·Age: 50 - 90

Code: NCT07169578·Phase 3·Recruiting

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Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD), Characterized by an Eosinophilic Phenotype

for Chronic Obstructive Pulmonary Disease

Drug: Lunsekimig

54 locations incl. Birmingham

Sponsor: Sanofi

Sex: All·Age: 40 - 80

Code: NCT07190222·Phase 3·Recruiting

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Use of fenoTRACK Device for Monitoring Changes of Fractional Exhaled Nitric Oxide (FeNO) in Uncontrolled Asthma Subjects and Controlled Asthma Subjects

for Asthma

13 locations incl. Stockton

Sponsor: Biometry Inc

Sex: All·Age: 5 - 100

Code: NCT07228026·Recruiting

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Improving Needs Among Older Adults

for Critical Illness

4 locations incl. Birmingham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06588556·Recruiting

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Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD) Characterized by an Eosinophilic Phenotype

for Chronic Obstructive Pulmonary Disease

Drug: Lunsekimig

63 locations incl. Chandler

Sponsor: Sanofi

Sex: All·Age: 40 - 80

Code: NCT07190209·Phase 3·Recruiting

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Epidermal Sensors for Wireless and Enhanced Amputee Skin Tracking (E-SWEAT) Part 1

for Transtibial Amputation

1 location in Raleigh

Sponsor: North Carolina State University

Sex: All·Age: 18 - 75

Code: NCT07216183·Phase 1·Recruiting

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A Skin Image Reference Tool to Aid Healthcare Providers' Diagnosis

for Dermatologic Disease

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 10+

Code: NCT07033169·Recruiting

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A Study to Evaluate How Apitegromab Works in Subjects Who Are Less Than 2 Years Old and Have Spinal Muscular Atrophy

for Spinal Muscular Atrophy

Drug: Apitegromab

14 locations incl. Phoenix

Sponsor: Scholar Rock, Inc.

Sex: All·Age: Up to 2

Code: NCT07047144·Phase 2·Recruiting

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A Web-Based Tool to Help People With Health Conditions Make Contraceptive Decisions

for Contraceptive Usage

18 locations incl. Phoenix

Sponsor: University of Michigan

Sex: Female·Age: 18 - 49

Code: NCT07075536·Enrolling By Invitation

Evaluation of Efficacy and Safety of Iloperidone for the Treatment of Participants With Uncontrolled Hypertension

for Hypertension

28 locations incl. Phoenix

Sponsor: Vanda Pharmaceuticals

Sex: All·Age: 18 - 65

Code: NCT07090161·Phase 2·Recruiting

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A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee

for Osteoarthritis

Drug: Orforglipron

26 locations incl. Phoenix

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07153471·Phase 3·Recruiting

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Intent of Surgery for IPMN

for Intraductal Papillary Mucinous Neoplasm

8 locations incl. Phoenix

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT07216521·Recruiting

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A Study to Test Whether Nerandomilast Helps People With Lungfibrosis Related to Rheumatic Diseases

for Interstitial Lung Diseases

Drug: Nerandomilast

33 locations incl. Birmingham

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06806592·Phase 3·Recruiting

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A Dose-masked Study of Intravitreal EYE103 in Participants With NVAMD or Macular Edema Following BRVO

for Neovascular Age-Related Macular Degeneration (NVAMD)

49 locations incl. Scottsdale

Sponsor: EyeBiotech Ltd.

Sex: All·Age: 18+

Code: NCT07205887·Phase 2·Recruiting

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A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)

for Breast Neoplasms

46 locations incl. Hot Springs

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT06926868·Phase 2, Phase 3·Recruiting

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Bracing and Reconstruction of the Anterior Cruciate Ligament for Efficacy Trial

for Anterior Cruciate Ligament Injuries

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 14 - 39

Code: NCT06942754·Recruiting

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Once Daily Intrapleural Enzyme Therapy in Complicated Parapneumonic Effusion or Empyema

for Pleural Infection Bacterial

6 locations incl. New Haven

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT07095361·Phase 4·Recruiting

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Caring for the Carer

for Care Burden

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT07167641·Recruiting

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pH1N1 Blinded Challenge Study

for Influenza

2 locations incl. Baltimore

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07110532·Phase 1·Recruiting

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A Phase 2 Open-label Study to Evaluate the Safety of Laruparetigene Zovaparvovec Administered Bilaterally in Male Participants With X-Linked Retinitis Pigmentosa

for X-Linked Retinitis Pigmentosa (XLRP)

6 locations incl. Jacksonville

Sponsor: Beacon Therapeutics

Sex: Male·Age: 12 - 50

Code: NCT07174726·Phase 2·Recruiting

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Developing and Testing Drone-Delivered AEDs for Cardiac Arrests In Rural America

for Cardiac Arrest

1 location in Clemmons

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06229418·Recruiting

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Study of Casdatifan and Cabozantinib Versus Placebo and Cabozantinib in Patients With Advanced Clear Cell Renal Cell Carcinoma

for Metastatic Clear Cell Renal Cell Carcinoma

Drug: Cabozantinib

40 locations incl. Gilbert

Sponsor: Arcus Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT07011719·Phase 3·Recruiting

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Education & Mentorship of Advanced Practice Providers to Increase Community-based Research Within the NCORP Network, COACH-APP Trial

for Other

31 locations incl. Newark

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06904391·Recruiting

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A Study to Evaluate the Safety and Efficacy of BGB-16673 Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

for Chronic Lymphocytic Leukemia

36 locations incl. Phoenix

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT06973187·Phase 3·Recruiting

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A Study of Healthy Donor CD19-targeted Allogeneic CAR T Cells in Participants With Severe, Refractory Autoimmune Diseases

for Refractory Autoimmune Diseases

2 locations incl. Boston

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT07115745·Phase 1·Recruiting

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Mobile Intervention for Suicidal Thoughts

for Suicide

1 location in Durham

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT06593379·Recruiting

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A Study of GNTI-122 in Adults Recently Diagnosed With T1D

for Type 1 Diabetes (T1D)

10 locations incl. Duarte

Sponsor: GentiBio, Inc

Sex: All·Age: 18 - 55

Code: NCT06919354·Phase 1·Recruiting

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Tenosynovial Giant Cell Tumor (TGCT) Real-World Participant Experience With Vimseltinib

for Tenosynovial Giant Cell Tumor

1 location in Wilmington

Sponsor: Deciphera Pharmaceuticals, LLC

Sex: All·Age: 18+

Code: NCT07075471·Recruiting

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Phase 2 Study of Inhaled SNG001 in Mechanically Ventilated Patients With Respiratory Viral Infection

for Viral Pneumonia

22 locations incl. Sacramento

Sponsor: Synairgen Research Ltd.

Sex: All·Age: 18+

Code: NCT06999603·Phase 2·Recruiting

Apply to this trial