A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee

Part of paid clinical trials in Phoenix, Arizona.

Sponsor
Eli Lilly and Company
Study ID
NCT07153471
Phase
PHASE3
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Orforglipron — DRUG
    Administered orally
  • Placebo — DRUG
    Administered orally

Study Details

The GZPT master protocol will support two independent studies, J2A-MC-GZT1 and J2A-MC-GZT2. Each study will see how well and safely orforglipron works in people with obesity or overweight who have osteoarthritis (OA) of the knee with pain. Participation in the study will last about 74 weeks.

Key Dates

Start date
Sep 15, 2025
Status verified
Jun 2026
Primary completion
Apr 30, 2028
Completion
May 31, 2028

Study Design

Enrollment
800 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Orforglipron (GZT1)
    Participants will receive orforglipron orally
  • Placebo Comparator: Placebo (GZT1)
    Participants will receive placebo orally
  • Experimental: Orforglipron (GZT2)
    Participants will receive orforglipron orally
  • Placebo Comparator: Placebo (GZT2)
    Participants will receive placebo orally

Primary Outcome Measure

Change from Baseline in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale Score [ Time Frame: Baseline, Week 72 ]

Central Contacts

  • Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
    1-317-615-4559
    [email protected]
  • Physicians interested in becoming principal investigators please contact
    [email protected]

Locations (26)

FacilityCityStateZIPSite coordinators
Arizona Research CenterPhoenixArizona85053
602-863-6363
Louise Taber MD (PRINCIPAL_INVESTIGATOR)
AMR ClinicalTempeArizona85281
602-910-3343
William Reedy (PRINCIPAL_INVESTIGATOR)
Care Access - Huntington BeachHuntington BeachCalifornia92648
714-378-2440
Christine Thai (PRINCIPAL_INVESTIGATOR)
Care Access - Thousand OaksThousand OaksCalifornia91360
805-778-5143
Elvira Lindwall (PRINCIPAL_INVESTIGATOR)
Legacy Clinical TrialsColorado SpringsColorado80909
719-387-7572
Charles Bird (PRINCIPAL_INVESTIGATOR)
Chase Medical Research, LLCWaterburyConnecticut06708
203-419-4420
Joseph Soufer (PRINCIPAL_INVESTIGATOR)
Care Access - DecaturDecaturGeorgia30030
678-470-4394
Marie Walton (PRINCIPAL_INVESTIGATOR)
North Georgia Clinical ResearchWoodstockGeorgia30189
678-494-5735
Bram Wieskopf (PRINCIPAL_INVESTIGATOR)
Northwestern UniversityChicagoIllinois60611
312-503-2315
Thomas Schnitzer (PRINCIPAL_INVESTIGATOR)
AMR ClinicalNewtonKansas67114
316-804-7304
Troy Holdeman (PRINCIPAL_INVESTIGATOR)
MedVadis Research CorporationWalthamMassachusetts02451
617-744-1310
David DiBenedetto (PRINCIPAL_INVESTIGATOR)
StudyMetrix ResearchCity of Saint PetersMissouri63303
636-387-5100
Timothy Smith (PRINCIPAL_INVESTIGATOR)
AMR ClinicalKansas CityMissouri64114
Martha Fanning (PRINCIPAL_INVESTIGATOR)
Cardio Metabolic InstituteSomersetNew Jersey08873
732-846-7000 x 108
Dinesh Singal (PRINCIPAL_INVESTIGATOR)
Carolina Research CenterShelbyNorth Carolina28150
704-600-6052
Stephen Jones (PRINCIPAL_INVESTIGATOR)
University Orthopedics CenterAltoonaPennsylvania16602
Joshua Greenleaf (PRINCIPAL_INVESTIGATOR)
Care Access - Rapid CityRapid CitySouth Dakota57701
877-791-0656
Ali Bajwa (PRINCIPAL_INVESTIGATOR)
AMR ClinicalKnoxvilleTennessee37909
865-305-9100
Jerry Punch (PRINCIPAL_INVESTIGATOR)
Mercy Family ClinicDallasTexas75208
281-944-3610
Ebere Israel Azubuike, MD (PRINCIPAL_INVESTIGATOR)
Biopharma Informatic, LLCHoustonTexas77084
281-944-3610
Kiran Farheen, MD (PRINCIPAL_INVESTIGATOR)
Juno ResearchHoustonTexas77040
713-779-5494
Damaris Vega (PRINCIPAL_INVESTIGATOR)
Activian Clinical ResearchKingwoodTexas77339
832-969-3401
Martin Basaldua (PRINCIPAL_INVESTIGATOR)
Advanced Rheumatology of Houston - WoodlandsThe WoodlandsTexas77382
936-681-4882
Tamar Brionez (PRINCIPAL_INVESTIGATOR)
Charlottesville Medical ResearchCharlottesvilleVirginia22911
434-817-2442
James Clark (PRINCIPAL_INVESTIGATOR)
Gershon Pain SpecialistsVirginia BeachVirginia23454
757-496-2050
Steven Gershon (PRINCIPAL_INVESTIGATOR)
Northwest Clinical Research CenterBellevueWashington98007
Jeena Vaid (PRINCIPAL_INVESTIGATOR)

Find similar trials in Phoenix, AZ

By condition
Osteoarthritis (other)
By specialty
OrthopedicsMusculoskeletal disorders
By research site
Arizona Research Center· Phoenix, AZAMR Clinical· Tempe, AZCare Access - Huntington Beach· Huntington Beach, CACare Access - Thousand Oaks· Thousand Oaks, CALegacy Clinical Trials· Colorado Springs, COChase Medical Research, LLC· Waterbury, CT

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