Paid Clinical Trials in North Carolina

North Carolina has 2,930 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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2,930 clinical trials

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The HIgh-fidelity Hydraulic couPling Upper-arm Cuff Assessment of Limits, Safety, and Effectiveness (HIPULSE) Trial

for Non-cardiac Surgical

3 locations incl. Boston

Sponsor: Philips Clinical & Medical Affairs Global

Sex: All·Age: 18+

Code: NCT06895590·Recruiting

Apply to this trial

Safety of RSV Preventive Monoclonal Antibody

for Fever

6 locations incl. Oakland

Sponsor: Duke University

Sex: All·Age: 6 Weeks - 30 Weeks·Accepts healthy volunteers

Code: NCT07158814·Phase 4·Recruiting

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BEACON-1: Study of AVZO-103 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Urothelial Cancer or Other Solid Tumors (AVZO-103-1001)

for Solid Tumor Cancer

10 locations incl. San Francisco

Sponsor: Avenzo Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07193511·Phase 1, Phase 2·Recruiting

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CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis

for Transthyretin Amyloid Cardiomyopathy (ATTR CM)

Drug: Coramitug

61 locations incl. Phoenix

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07207811·Phase 3·Recruiting

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The DART DELIVER-02 Study

for HIV (Human Immunodeficiency Virus)

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 65

Code: NCT07217379·Phase 1·Recruiting

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Accelerometer Measured Early Recovery After Prolapse Surgery

for Pelvic Organ Prolapse

7 locations incl. San Diego

Sponsor: NICHD Pelvic Floor Disorders Network

Sex: Female·Age: 18 - 99

Code: NCT07218016·Recruiting

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Widefield Confocal Scanning Laser Ophthalmoscope Optimized for Pediatric and Neonatal Imaging

for Eye Diseases

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 30 Days+·Accepts healthy volunteers

Code: NCT06177639·Recruiting

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A Randomized Phase II Study Of Bruton Tyrosine Kinase Inhibitor With Or Without Venetoclax In Veterans With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

for Chronic Lymphocytic Leukemia

Drug: Venetoclax

4 locations incl. San Francisco

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 80

Code: NCT06520098·Phase 2·Recruiting

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Leveraging Interactive Digital Technology to Increase Access to Family-Based Behavioral Treatment for Childhood Obesity

for Childhood Obesity

1 location in Durham

Sponsor: 3-C Institute for Social Development

Sex: All·Age: 6+·Accepts healthy volunteers

Code: NCT06728800·Not Yet Recruiting

Clinical Trial of N-803 Plus Tislelizumab or Prior Failed Immune Checkpoint Inhibitor and Docetaxel Versus Docetaxel Monotherapy in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Acquired Resistance to Immune Checkpoint In

for NSCLC Stage IV

19 locations incl. Springdale

Sponsor: ImmunityBio, Inc.

Sex: All·Age: 18 - 90

Code: NCT06745908·Phase 3·Recruiting

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Targeted Palliative Care Intervention for Patients With Metastatic Breast Cancer

for Metastatic Breast Cancer

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06795529·Recruiting

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A Study to Evaluate INCA035784 in Participants With Myeloproliferative Neoplasms

for Myeloproliferative Neoplasms

12 locations incl. Phoenix

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT07008118·Phase 1·Recruiting

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Optimal Ventilation for Cardiac Arrest

for Cardiac Arrest (CA)

20 locations incl. Orange

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 37 Weeks - 18

Code: NCT07114510·Recruiting

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An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease

for Crohn's Disease

Drug: Duvakitug

93 locations incl. Peoria

Sponsor: Sanofi

Sex: All·Age: 16 - 80

Code: NCT07184931·Phase 3·Recruiting

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A Protocol of Icotrokinra Therapy in Adult and Adolescent Participants With Moderately to Severely Active Ulcerative Colitis

for Colitis, Ulcerative

54 locations incl. Chandler

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 12+

Code: NCT07196748·Phase 3·Recruiting

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Dissemination of BREASTChoice AIM1-B

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07396766·Recruiting

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Veterans Enhanced Recovery Using Integrative Treatments Around Surgery

for Anesthesia

1 location in Durham

Sponsor: Durham VA Medical Center

Sex: All·Age: 18+

Code: NCT06333938·Phase 4·Not Yet Recruiting

Hormone Replacement Therapy After Risk Reducing Salpingo-oophorectomy

for BRCA1 Mutation

2 locations incl. Chapel Hill

Sponsor: Duke University

Sex: Female·Age: 19 - 50

Code: NCT06972719·Recruiting

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Study of Trastuzumab Deruxtecan Versus Standard of Care Chemotherapy for HER2-Expressing (IHC 3+/2+) Endometrial Cancer

for Endometrial Cancer

8 locations incl. Fort Lauderdale

Sponsor: Daiichi Sankyo

Sex: Female·Age: 18+

Code: NCT07022483·Phase 3·Recruiting

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Safety, Tolerability, and Efficacy of NVG-2089 in Participants With Immune Thrombocytopenia

for Immune Thrombocytopenia (ITP)

1 location in Greenville

Sponsor: Nuvig Therapeutics, Inc.

Sex: All·Age: 18 - 80

Code: NCT07095127·Phase 2·Recruiting

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A Study of mRNA-2808 in Participants With Relapsed or Refractory Multiple Myeloma

for Relapsed or Refractory Multiple Myeloma

10 locations incl. Birmingham

Sponsor: ModernaTX, Inc.

Sex: All·Age: 18+

Code: NCT07116616·Phase 1, Phase 2·Recruiting

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Pivotal Study on the NOVABLOC System for Patients Undergoing Primary Total Knee Arthroplasty

for Pain

5 locations incl. Daphne

Sponsor: Synaptrix, Inc.

Sex: All·Age: 21+

Code: NCT07191067·Recruiting

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Evaluation of a Non-Implanted Electrical Stimulation Device for Overactive Bladder (OAB)

for Overactive Bladder (OAB)

15 locations incl. Beverly Hills

Sponsor: FemPulse Corporation

Sex: Female·Age: 21+

Code: NCT07195656·Recruiting

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Study to Assess the Adverse Events of Oral ABBV-932 in Adult Participants With Depressive Episodes Associated With Bipolar I or II Disorder

for Bipolar I or II Disorder

47 locations incl. Phoenix

Sponsor: AbbVie

Sex: All·Age: 18 - 65

Code: NCT07220460·Phase 2·Recruiting

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A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)

for Ulcerative Colitis

8 locations incl. Lancaster

Sponsor: Genentech, Inc.

Sex: All·Age: 18+

Code: NCT06979336·Phase 2·Recruiting

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Inhaled Treprostinil (Tyvaso Nebulizer) For COPD Patients With Hypoxemia

for COPD (Chronic Obstructive Pulmonary Disease)

1 location in Durham

Sponsor: Bastiaan Driehuys

Sex: All·Age: 40+

Code: NCT07037836·Phase 2·Recruiting

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Prospective Clinical Evaluation of the BioFire Emerging Coronavirus Panel for the Detection of COVID-19 and Other Coronaviruses

for Coronavirus

6 locations incl. Los Angeles

Sponsor: BioFire Defense LLC

Sex: All·Age: All ages

Code: NCT07221097·Recruiting

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This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.

for Metastatic Castration Sensitive Prostate Cancer (mCSPC)

Drug: Mevrometostat

120 locations incl. Huntsville

Sponsor: Pfizer

Sex: Male·Age: 18+

Code: NCT07028853·Phase 3·Recruiting

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Woodsmoke Exposure, Influenza Infection, and Nasal Immunity

for Smoke Exposure

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 49·Accepts healthy volunteers

Code: NCT06841913·Phase 4·Recruiting

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Studies to Assess Ziftomenib in Combination With Ven+Aza or 7+3 in Patients With Untreated NPM1-m or KMT2A-r AML

for Acute Myeloid Leukemia (AML)

42 locations incl. Gilbert

Sponsor: Kura Oncology, Inc.

Sex: All·Age: 18+

Code: NCT07007312·Phase 3·Recruiting

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Study of Datopotamab Deruxtecan Plus Carboplatin or Cisplatin Versus Gemcitabine Plus Carboplatin or Cisplatin in Participants With Locally Advanced or Metastatic Urothelial Carcinoma

for Urothelial Cancer

38 locations incl. Fullerton

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT07129993·Phase 2, Phase 3·Recruiting

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A Study to Evaluate the Safety and Efficacy of CD388 for Prevention of Influenza

for Influenza

120 locations incl. Anniston

Sponsor: Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Sex: All·Age: 12+

Code: NCT07159763·Phase 3·Recruiting

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Study to Evaluate the Pharmacokinetics (PK), Safety and Tolerability up to 6 Years of Intravenous (i.v.) Secukinumab in Pediatric Participants With Juvenile Psoriatic Arthritis (JPsA).

for Juvenile Psoriatic Arthritis

Drug: Secukinumab

8 locations incl. Gainesville

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 2 - 17

Code: NCT06751238·Phase 1·Recruiting

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Healthy Living Anson Study

for Obesity (Disorder)

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT07126587·Recruiting

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A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations

for Breast Cancer

14 locations incl. Orlando

Sponsor: Terremoto Biosciences Inc.

Sex: All·Age: 18+

Code: NCT07109726·Phase 1, Phase 2·Recruiting

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A Study of PHN-012 in Patients With Advanced Solid Tumors

for Colon Cancer

11 locations incl. Los Angeles

Sponsor: Pheon Therapeutics

Sex: All·Age: 18+

Code: NCT07127874·Phase 1·Recruiting

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Intra-Arterial Tenecteplase Following Endovascular Thrombectomy for Large Vessel Occlusion Stroke

for Acute Ischemic Stroke

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06781385·Phase 2·Enrolling By Invitation

GORE® Ascending Stent Graft in the Treatment of De Novo Type A Aortic Dissections

for Aortic Dissection

16 locations incl. Birmingham

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT06827990·Recruiting

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A Study to Investigate Airway Inflammation With Dupilumab Subcutaneously in Participants Aged ≥40 to ≤85 Years With Chronic Obstructive Pulmonary Disease.

for Chronic Obstructive Pulmonary Disease

Drug: Dupilumab

9 locations incl. Birmingham

Sponsor: Sanofi

Sex: All·Age: 40 - 85

Code: NCT07053423·Phase 4·Recruiting

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Evaluation of Treatment Satisfaction and KarXT Utilization Registry (RESKU)

for Schizophrenia

Drug: KarXT

18 locations incl. Orange

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07101094·Recruiting

Apply to this trial