Paid Clinical Trials in North Carolina

North Carolina has 2,930 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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2,930 clinical trials

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A Study to Assess Adverse Events and Change in Disease Activity in Adult Participants Receiving Intravenously Infused Telisotuzumab Adizutecan Alone or With Standard of Care in Participants With Post Adjuvant Circulating Tumor DNA Positive Colorectal Cancer and No Radiographic Evidence of Disease

for Colorectal Cancer

22 locations incl. Huntsville

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT07023289·Phase 2·Recruiting

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OPI-NXYDLD-303 Safety and Efficacy of Phentolamine Ophthalmic Solution in Keratorefractive Surgery Participants With Decreased Mesopic Visual Acuity

for Vision Loss Night

23 locations incl. Chandler

Sponsor: Ocuphire Pharma, Inc.

Sex: All·Age: 18+

Code: NCT07140783·Phase 3·Recruiting

Apply to this trial

Provider Skill Building for Engagement and Communication in Healthcare - Hypertension Management

for Patient-centered Care

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07147075·Enrolling By Invitation

Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)

for Elevated Lp(a)

Drug: Muvalaplin

121 locations incl. Gilbert

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07157774·Phase 3·Recruiting

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SNAPS Breast Cancer Patient Study Breast Cancer Patients

for Breast Cancer

1 location in Durham

Sponsor: Immunis.AI

Sex: Female·Age: 18+

Code: NCT05370300·Not Yet Recruiting

A Targeted Electronic Health Approach to Reduce Fear of Recurrence in Breast Cancer Survivors (FoRtitude)

for Breast Cancer Survivor

1 location in Chapel Hill

Sponsor: Eastern Cooperative Oncology Group

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT07122492·Not Yet Recruiting

Hospital-to-Home Transitional Care Interventions (H2H-TCI) Children/Youth With Special Health Care Needs (CYSHCN)

for Health Care

2 locations incl. Chapel Hill

Sponsor: Duke University

Sex: All·Age: Up to 18

Code: NCT06428175·Recruiting

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Bump the Lump - Intervention for the Treatment of Globus Pharyngeus

for Globus Pharyngeus

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06762444·Recruiting

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A Single-arm, Phase II Clinical Trial of ASPIRin to prEvent Venous Thromboembolism in Patients With Advanced Germ Cell Tumors Receiving Chemotherapy

for Germ Cell Tumor

3 locations incl. Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18 - 70

Code: NCT06866964·Phase 2·Recruiting

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Long Term Follow-up Study for Subjects Administered CLBR001

for Long Term Follow-Up

3 locations incl. Indianapolis

Sponsor: Calibr, a division of Scripps Research

Sex: All·Age: 18+

Code: NCT06882317·Enrolling By Invitation

Clinical Evaluation of WaveLight Plus LASIK

for Myopia

1 location in Greensboro

Sponsor: Laser Defined Vision

Sex: All·Age: 18+

Code: NCT07127757·Recruiting

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An Open-Label Extension Study of Batoclimab in Adult Participants With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

for Chronic Inflammatory Demyelinating Polyneuropathy

Drug: Batoclimab

5 locations incl. New Haven

Sponsor: Immunovant Sciences GmbH

Sex: All·Age: 18+

Code: NCT07188844·Phase 2·Enrolling By Invitation

Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors

for Solid Tumor Malignancies

13 locations incl. Denver

Sponsor: Tasca Therapeutics

Sex: All·Age: 18+

Code: NCT07030257·Phase 1, Phase 2·Recruiting

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Optimizing Timing of Cesarean Delivery Consent on Labor and Delivery

for Pregnancy

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: 18+

Code: NCT07117708·Recruiting

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A Phase II Nationwide, Fully Decentralized, Telemedicine Study of Pemigatinib in Adult Patients With Advanced or Metastatic Pancreatic Cancer With FGFR Genetic Alterations

for Advanced Pancreatic Carcinoma

109 locations incl. Birmingham

Sponsor: Sameek Roychowdhury

Sex: All·Age: 18+

Code: NCT06906562·Phase 2·Recruiting

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A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Patients With Invasive Mold Infections.

for Invasive Mold Infections

15 locations incl. Birmingham

Sponsor: Basilea Pharmaceutica

Sex: All·Age: 18+

Code: NCT06925321·Phase 3·Recruiting

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Study to Evaluate Efficacy and Dose Response of Imapextide (STEADI)

for Postbariatric Hypoglycemia

4 locations incl. Aurora

Sponsor: MBX Biosciences

Sex: All·Age: 18 - 75

Code: NCT07029412·Phase 2·Recruiting

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Safety and Efficacy of ABP-745 in Participants With an Acute Gout Flare

for Acute Gouty Arthritis

14 locations incl. Peoria

Sponsor: Atom Therapeutics Co., Ltd

Sex: All·Age: 18 - 70

Code: NCT07145229·Phase 2·Recruiting

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855303-RNA Biomarker Validation

for Fractures, Bone

7 locations incl. Sacramento

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06872775·Enrolling By Invitation

An International Observational Study of Adults With Acute Infection

for Infectious Disease

18 locations incl. Tucson

Sponsor: University of Minnesota

Sex: All·Age: 18+

Code: NCT07069400·Recruiting

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Enhancing Resilience Among Patients With Stroke: Implementation of High Intensity Home-based Rehabilitation

for Stroke

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07098286·Enrolling By Invitation

BEATRIX: A Study to Learn About a Group B Streptococcus Vaccine in Healthy Pregnant Women and Their Babies

for Healthy

114 locations incl. Birmingham

Sponsor: Pfizer

Sex: All·Age: 1 Day - 49·Accepts healthy volunteers

Code: NCT07160244·Phase 3·Recruiting

Apply to this trial

Telerehabilitation In The Home After Stroke

for Stroke

27 locations incl. Downey

Sponsor: University of California, Los Angeles

Sex: All·Age: 18 - 80

Code: NCT06682429·Recruiting

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HCMT/MM2401: Ph2 Study of Selinexor + Bispecific Antibody for RRMM

for Multiple Myeloma in Relapse

Drug: Selinexor

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06822972·Phase 2·Recruiting

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Molecular Residual Disease Assessment in a Representative Diverse Population of Patients With Early-stage Breast Cancer

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07025785·Recruiting

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OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events

for Cardiovascular Disease

Drug: Olpasiran

204 locations incl. Alexander City

Sponsor: Amgen

Sex: All·Age: 50 - 105

Code: NCT07136012·Phase 3·Recruiting

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Validation of Chronic Obstructive Pulmonary Disease (COPD) Algorithm

for COPD (Chronic Obstructive Pulmonary Disease)

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 40+

Code: NCT07223749·Recruiting

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LCI-SAR-BSTS-CTDNA-001: Circulating Tumor DNA Liquid Biopsy in Sarcoma Patients

for Sarcoma

2 locations incl. Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: All ages

Code: NCT06958107·Recruiting

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Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer

for Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma

279 locations incl. Gilbert

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT06958328·Phase 3·Recruiting

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AGENT DCB STANCE: Safety and Effectiveness Study of AGENT Drug-Coated Balloon Compared to Standard of Care Percutaneous Coronary Intervention (PCI) Treatment for de Novo Coronary Lesions

for Coronary Arterial Disease (CAD)

42 locations incl. La Jolla

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT06959524·Recruiting

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Study of BHV-1300 in Graves' Disease

for Graves Disease

10 locations incl. South Gate

Sponsor: Biohaven Therapeutics Ltd.

Sex: All·Age: 18 - 65

Code: NCT06980649·Phase 1·Recruiting

Apply to this trial

Osteoarthritis Care Tools for Primary Care Providers

for Arthritis

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT06988163·Enrolling By Invitation

Accelerated TMS for MDD

for Major Depressive Disorder

3 locations incl. New York

Sponsor: Neuronetics

Sex: All·Age: 15+

Code: NCT07147218·Recruiting

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A Study of Pitolisant in Participants With Prader-Willi Syndrome

for Prader-Willi Syndrome

1 location in Morrisville

Sponsor: Harmony Biosciences Management, Inc.

Sex: All·Age: 7+

Code: NCT07219485·Phase 3·Enrolling By Invitation

Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 18+

Code: NCT06727773·Phase 2·Recruiting

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Testing the Addition of Paclitaxel Administered Into the Abdominal Cavity Combined With Chemotherapy for Patients With Gastric Cancer Spread to the Abdominal Cavity

for Gastric Adenocarcinoma

55 locations incl. Irvine

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT07001748·Phase 2, Phase 3·Recruiting

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Quitting Matters Human Immunodeficiency Virus Hybrid Trial

for Tobacco

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06883097·Recruiting

Apply to this trial

Sequential Multiple Assignment Randomized Trial to Reduce Food Insecurity

for Uncontrolled Hypertension

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT07031739·Recruiting

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A Study of XB371 Administered in Participants With Locally Advanced or Metastatic Solid Tumors

for Solid Tumors

9 locations incl. Rogers

Sponsor: Exelixis

Sex: All·Age: 18+

Code: NCT07123103·Phase 1·Recruiting

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A Study to Evaluate the Maintenance Effect of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

for Major Depressive Disorder

Drug: NBI-1065845

18 locations incl. Oceanside

Sponsor: Neurocrine Biosciences

Sex: All·Age: 18+

Code: NCT07196501·Phase 3·Recruiting

Apply to this trial