Paid Clinical Trials in North Carolina

North Carolina has 2,930 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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2,930 clinical trials

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Testing the Anti-cancer Drug, Cirtuvivint, and Its Combination With ASTX727 to Improve Outcomes in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndromes

for Acute Myeloid Leukemia

22 locations incl. New Haven

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06484062·Phase 1·Recruiting

Apply to this trial

AMD and Validation Rod-Meditated Dark Adaptation With Everyday Task Performance

for Age-Related Macular Degeneration

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 50 - 89·Accepts healthy volunteers

Code: NCT06619405·Recruiting

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FIBERGRAFT Aeridyan Posterolateral Fusion Study

for Degenerative Spine Disease

8 locations incl. Sacramento

Sponsor: DePuy Synthes Products, Inc.

Sex: All·Age: 18+

Code: NCT07059065·Recruiting

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MiREA-AC for Reducing Problematic Alcohol and Marijuana Use in College Students

for Alcohol Misuse

2 locations incl. Charlotte

Sponsor: mHealth Systems Inc.

Sex: All·Age: 18 - 26·Accepts healthy volunteers

Code: NCT07339150·Recruiting

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A New Intervention to Improve Function in Veterans With Anxiety and Depression

for Anxiety and Depression

1 location in Durham

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 65

Code: NCT06188923·Phase 2·Recruiting

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Caring Connections Youth Suicide Detection and Intervention Study

for Suicide

1 location in Charlotte

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 13+

Code: NCT06353711·Recruiting

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A Mobile Intervention to Reduce Pain and Improve Health-III

for Chronic Pain

1 location in Winston-Salem

Sponsor: Wake Forest University

Sex: All·Age: 65+

Code: NCT06623669·Phase 2·Recruiting

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A Follow-up Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia

for Immune Thrombocytopenic Purpura (ITP)

17 locations incl. Los Angeles

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06948318·Phase 3·Recruiting

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Open-label Extension Study in Participants With Early Alzheimer's Disease

for Alzheimer's Disease

9 locations incl. Maitland

Sponsor: GlaxoSmithKline

Sex: All·Age: 50 - 85

Code: NCT07105709·Phase 2·Recruiting

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Pain With Dementia

for Pain

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 50+·Accepts healthy volunteers

Code: NCT06854718·Recruiting

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A Study Investigating Intravenous Human Normal Immunoglobulin 10% in Adults With Chronic Immune Thrombocytopenia (ITP)

for Chronic Primary Immune Thrombocytopenia (ITP)

2 locations incl. Los Angeles

Sponsor: Kedrion S.p.A.

Sex: All·Age: 18 - 70

Code: NCT07059000·Phase 3·Recruiting

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Abbott Cephea Mitral Valve Disease Registry

for Mitral Regurgitation

22 locations incl. Phoenix

Sponsor: Abbott Medical Devices

Sex: All·Age: 18+

Code: NCT07069673·Recruiting

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Mirikizumab in the Treatment of Chronic Inflammatory Conditions of the Pouch

for Pouchitis

5 locations incl. Los Angeles

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 80

Code: NCT06864403·Phase 4·Recruiting

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Rademikibart Add-on Treatment of an Acute COPD Exacerbation (Seabreeze STAT COPD)

for COPD Acute Exacerbation

22 locations incl. Birmingham

Sponsor: Connect Biopharm LLC

Sex: All·Age: 40 - 80

Code: NCT06940154·Phase 2·Recruiting

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Pilot Study of Personalized Aperiodic Transcranial Alternating Current Stimulation in Antenatal Depression (PandA-tACS)

for Antenatal Depression

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT06979154·Recruiting

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A Phase 2, Open-Label Study of DISC-3405 in Participants With Polycythemia Vera (PV)

for Polycythemia Vera (PV)

15 locations incl. Phoenix

Sponsor: Disc Medicine, Inc

Sex: All·Age: 18+

Code: NCT06985147·Phase 2·Recruiting

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A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors

for Advanced Solid Tumor

18 locations incl. Phoenix

Sponsor: BioNTech SE

Sex: All·Age: 18+

Code: NCT07070232·Phase 1, Phase 2·Recruiting

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A Long-term Extension Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia

for Narcolepsy Type 1

Drug: ORX750

19 locations incl. Auburn

Sponsor: Centessa Pharmaceuticals (UK) Limited

Sex: All·Age: 18 - 65

Code: NCT07096674·Phase 2·Recruiting

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Comparing a Workplace Resilience and a Physical Activity Intervention on Early Childhood Educators Well-being

for Resilience

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT06919952·Recruiting

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A Research Study to See How a Weekly Insulin, Insulin Icodec, Helps in Reducing the Blood Sugar Compared to Daily Insulin Glargine, Both in Combination With Insulin Aspart, in Adults With Type 1 Diabetes

for Diabetes Mellitus, Type 1

109 locations incl. Cullman

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07076199·Phase 3·Recruiting

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Real-World Efgartigimod Effectiveness in CIDP: A Prospective Study

for Chronic Inflammatory Demyelinating Polyradiculoneuropathy

1 location in Wilmington

Sponsor: argenx

Sex: All·Age: 18+

Code: NCT07264426·Recruiting

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Microplastic Exposure From Clear Aligner Wear (MPE)

for Microplastic Exposure

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 10 - 75

Code: NCT06934603·Recruiting

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Frontline T-cell Engager vs Autologous Stem Cell Transplant (ASCT) and Measurable Residual Disease (MRD)-Guided Sequential Intensification thERapy in Multiple Myeloma

for Multiple Myeloma, Newly Diagnosed

11 locations incl. Birmingham

Sponsor: SCRI Development Innovations, LLC

Sex: All·Age: 19+

Code: NCT06974786·Phase 2·Recruiting

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Safety and Efficacy of Boric Acid Inserts for Treatment of Vulvovaginal Candidiasis

for Vulvovaginal Candidiases

27 locations incl. Mobile

Sponsor: pH-D Feminine Health LLC

Sex: Female·Age: 12+

Code: NCT07109869·Phase 3·Recruiting

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A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression)

for Bipolar Disorder

28 locations incl. Tucson

Sponsor: Xenon Pharmaceuticals Inc.

Sex: All·Age: 18 - 74

Code: NCT07172516·Phase 3·Recruiting

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Ripe for Revival: Outcomes Evaluation of a Mobile Produce Market With Vouchers

for Diet Interventions

1 location in Raleigh

Sponsor: North Carolina State University

Sex: All·Age: 18+

Code: NCT07218978·Recruiting

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Trial of Ovarian Vein and Pelvic Vein Embolization in Women With Chronic Pelvic Pain and Pelvic Varices

for Chronic Pelvic Pain Syndrome

3 locations incl. New York

Sponsor: Weill Medical College of Cornell University

Sex: Female·Age: 18 - 75·Accepts healthy volunteers

Code: NCT06168058·Recruiting

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Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis

for Sickle Cell Disease Vaso-occlusive Crisis

16 locations incl. Oakland

Sponsor: CSL Behring

Sex: All·Age: 12+

Code: NCT06699849·Phase 2·Recruiting

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Study of Intravenously (IV) Infused Etentamig in Combination With an Oral Cereblon E3 Ligase Modulatory Drug (CELMoD) Agent Assessing Adverse Events and Change in Disease Activity in Adult Participants With Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma

Drug: Etentamig

7 locations incl. Beverly Hills

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06896916·Phase 1·Recruiting

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COMPASS Study for Metastatic Castration-resistant Prostate Cancer

for Prostate Cancer

3 locations incl. San Francisco

Sponsor: Duke University

Sex: Male·Age: 18+

Code: NCT07050433·Recruiting

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A Clinical Trial to Learn About the Effects of VHB937 in People With Early Alzheimer's Disease

for Alzheimer's Disease

24 locations incl. Phoenix

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 50 - 85

Code: NCT07094516·Phase 2·Recruiting

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Phase 2, Efficacy and Safety Study of ACP-204 in Lewy Body Dementia Psychosis

for Lewy Body Dementia Psychosis

26 locations incl. Irvine

Sponsor: ACADIA Pharmaceuticals Inc.

Sex: All·Age: 55 - 84

Code: NCT07029581·Phase 2·Recruiting

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A Study to Investigate Efficacy and Safety of Teplizumab Compared With Placebo in Participants 1 to 25 Years of Age With Stage 3 Type 1 Diabetes

for Type 1 Diabetes Mellitus

32 locations incl. Scottsdale

Sponsor: Sanofi

Sex: All·Age: 1 - 25

Code: NCT07088068·Phase 3·Recruiting

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Study of EN-374 Gene Therapy in Participants With X-Linked Chronic Granulomatous Disease

for X-Linked Chronic Granulomatous Disease

8 locations incl. Los Angeles

Sponsor: Ensoma

Sex: Male·Age: 3 Months+

Code: NCT06876363·Phase 1, Phase 2·Recruiting

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FiberLocker® System Augmentation of Rotator Cuff Repairs

for Rotator Cuff Tear

4 locations incl. Chicago

Sponsor: ZuriMED Technologies Inc.

Sex: All·Age: 30 - 70

Code: NCT06918041·Recruiting

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Study to Evaluate the Efficacy and Safety of Deuruxolitinib in Adolescents With Severe Alopecia Areata

for Alopecia Areata

54 locations incl. Birmingham

Sponsor: Sun Pharmaceutical Industries, Inc.

Sex: All·Age: 12 - 17

Code: NCT07133308·Phase 3·Recruiting

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A Study of Dotinurad Versus Allopurinol in Tophaceous Gout

for Tophaceous Gout

Drug: Dotinurad

86 locations incl. Birmingham

Sponsor: Crystalys Therapeutics

Sex: All·Age: 18 - 75

Code: NCT07089888·Phase 3·Recruiting

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Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

for High Grade Glioma

10 locations incl. Aurora

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 1 - 21·Accepts healthy volunteers

Code: NCT06333899·EARLY_Phase 1·Recruiting

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Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)

for Endometrial Cancer

68 locations incl. Tucson

Sponsor: AstraZeneca

Sex: Female·Age: 18+

Code: NCT07044336·Phase 3·Recruiting

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Individualizing Treatment for Asthma in Primary Care (Full Study)

for Asthma

13 locations incl. Aurora

Sponsor: DARTNet Institute

Sex: All·Age: 13 - 75

Code: NCT07052942·Phase 4·Recruiting

Apply to this trial