Pilot Study of Personalized Aperiodic Transcranial Alternating Current Stimulation in Antenatal Depression (PandA-tACS)

Part of paid clinical trials in Chapel Hill, North Carolina.

Sponsor
University of North Carolina, Chapel Hill
Study ID
NCT06979154
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 45 Years
Healthy Volunteers
Accepted

Interventions

  • tACS (aperiodic) — DEVICE
    Individualized tACS waveform based on aperiodic EEG activity will be delivered.

Study Details

The purpose of this study is to develop the safety, feasibility, and tolerability of a personalized transcranial alternating current stimulation (tACS) approach in antenatal depression.

Key Dates

Start date
Aug 12, 2025
Status verified
Apr 2026
Primary completion
Dec 1, 2026
Completion
Dec 1, 2026

Study Design

Enrollment
10 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
OTHER

Arms

  • Experimental: Healthy Control Group
    Aperiodic tACS delivered using a waveform based on individual participant EEG activity which has been modified to alter excitation/inhibition balance.
  • Experimental: Antenatal Depression Group
    Aperiodic tACS delivered using a waveform based on individual participant EEG activity which has been modified to alter excitation/inhibition balance.

Primary Outcome Measure

Safety via the presence of any serious AEs related to stimulation [ Time Frame: Day 1 to Follow-Up (Day 19) (HC) or Day 1 to end of monitoring (birth outcomes review within 90 days of expected delivery date) (antenatal depression) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Carolina Center for NeurostimulationChapel HillNorth Carolina27516
Zachary Stewart
[email protected]
919-966-9929
Athena Stein, PhD
[email protected]
9199669929
Flavio Frohlich, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Chapel Hill, NC

By condition
Depression
By specialty
PsychiatryMental healthBehavioral health
By research site
Carolina Center for Neurostimulation· Chapel Hill, NC

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