Paid Clinical Trials in North Carolina

North Carolina has 2,930 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

Filter results

Filter results

State

City

Phase

Study type

Intervention

Recruitment status

Condition

Sex

Age

Healthy volunteers only

2,930 clinical trials

↓ Download CSV

Continuous Glucose Monitoring, Diabetes Education, and Peer Support for Management of Uncontrolled Type 2 Diabetes

for Type 2 Diabetes Mellitus - Poor Control

1 location in Asheville

Sponsor: Whole Endo

Sex: All·Age: 18+

Code: NCT07054125·Recruiting

Apply to this trial

Developing a Digital Aid to Improve ICD Decisions

for Heart Failure and Reduced Ejection Fraction

2 locations incl. San Francisco

Sponsor: Stanford University

Sex: All·Age: 60+

Code: NCT07084142·Recruiting

Apply to this trial

A Study of Dotinurad Versus Allopurinol in Participants With Gout

for Gout

Drug: Dotinurad

80 locations incl. Birmingham

Sponsor: Crystalys Therapeutics

Sex: All·Age: 18 - 75

Code: NCT07089875·Phase 3·Recruiting

Apply to this trial

Trial Investigating Visugromab in Combination With Immunochemotherapy in 1L Treatment of Participants With Metastatic NSCLC

for Metastatic Non-Squamous Non-Small Cell Lung Cancer

6 locations incl. Birmingham

Sponsor: CatalYm GmbH

Sex: All·Age: 18+

Code: NCT07098988·Phase 2·Recruiting

Apply to this trial

Comparison of Epi-ON Corneal Collagen Crosslinking Performed Using an 18-Minute UVA Exposure vs. a 24-Minute UVA Exposure on Eyes With Ectatic Corneal Diseases

for Keratoconus

12 locations incl. Atlanta

Sponsor: Woolfson Eye Institute

Sex: All·Age: 8+

Code: NCT07124910·Phase 3·Recruiting

Apply to this trial

Compassionate Use Study of Epi-ON Corneal Collagen Crosslinking Performed Using UVA Exposure on Eyes With Ectatic Corneal Diseases for Subjects With Down Syndrome

for Down Syndrome (DS)

12 locations incl. Atlanta

Sponsor: Woolfson Eye Institute

Sex: All·Age: 8+

Code: NCT07135167·Phase 3·Recruiting

Apply to this trial

Detecting Pulmonary Hypertension With the Eko CORE 500 Digital Stethoscope

for Pulmnary Hypertension

2 locations incl. Los Angeles

Sponsor: Eko Devices, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07136623·Recruiting

Apply to this trial

Towards Efficient Personalization of Computerized Lower Limb Prostheses Via Reinforcement Learning in a Clinical Setup - Group 1

for Transfemoral Amputation

1 location in Raleigh

Sponsor: North Carolina State University

Sex: All·Age: 18 - 75

Code: NCT07204925·Phase 1·Recruiting

Apply to this trial

Enhancing Physical Function in Older Adults With Chronic Kidney Disease

for Chronic Kidney Diseases

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 65 - 100

Code: NCT06738394·Recruiting

Apply to this trial

A Phase IIb Ensifentrine-glycopyrrolate Fixed-dose Combination Dose Ranging Study in Subjects With COPD

for Chronic Obstructive Pulmonary Disease

57 locations incl. Dothan

Sponsor: Verona Pharma, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA

Sex: All·Age: 40 - 80

Code: NCT07016412·Phase 2·Recruiting

Apply to this trial

A Clinical Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-011)

for Human Immunodeficiency Virus (HIV)

23 locations incl. Birmingham

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 16+·Accepts healthy volunteers

Code: NCT07044297·Phase 3·Recruiting

Apply to this trial

AMG 410 Alone and in Combination With Other Agents in Participants With KRAS Altered Advanced or Metastatic Solid Tumors

for KRAS Altered Advanced or Metastatic Solid Tumors

9 locations incl. Duarte

Sponsor: Amgen

Sex: All·Age: 18+

Code: NCT07094113·Phase 1·Recruiting

Apply to this trial

Transition Health and Resilience Through Valued Experiences (THRiVE) Pilot for Newly Separated Veterans

for Military Transition

1 location in Durham

Sponsor: RTI International

Sex: All·Age: 18+

Code: NCT06778278·Recruiting

Apply to this trial

Testing the Addition of an Anti-Cancer Drug, Triapine, to the Usual Radiation Therapy for Recurrent Glioblastoma or Astrocytoma

for Astrocytoma, IDH-Mutant, Grade 2

42 locations incl. Duarte

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06860594·Phase 1·Recruiting

Apply to this trial

A Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal KSI-101 in Participants With Macular Edema Secondary to Inflammation (MESI) - PEAK

for Macular Edema Secondary to Inflammation

55 locations incl. Phoenix

Sponsor: Kodiak Sciences Inc

Sex: All·Age: 18+

Code: NCT06990399·Phase 3·Recruiting

Apply to this trial

RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

for Adjustment Disorder

30 locations incl. Birmingham

Sponsor: Reunion Neuroscience Inc

Sex: All·Age: 18 - 80

Code: NCT07002034·Phase 2·Recruiting

Apply to this trial

PReSeRVE-HD: Observational Study of the Merit HeRO® Graft and Super HeRO® in Patients on Hemodialysis

for End Stage Renal Disease

7 locations incl. Washington D.C.

Sponsor: Merit Medical Systems, Inc.

Sex: All·Age: 18+

Code: NCT06422871·Recruiting

Apply to this trial

Chronic Exogenous Ketosis in HFpEF

for Heart Failure With Preserved Ejection Fraction (HFPEF)

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06937320·Phase 2·Enrolling By Invitation

The Better, Harder, Faster, Stronger Study

for Frailty at Older Adults

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: Female·Age: 55+

Code: NCT07220512·Recruiting

Apply to this trial

Remote Ischemic Conditioning and Spinal Reflex Modulation in Children With Cerebral Palsy

for Children With Cerebral Palsy

1 location in Greenville

Sponsor: East Carolina University

Sex: All·Age: 8 - 17

Code: NCT07390760·Recruiting

Apply to this trial

A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation

for AML (Acute Myelogenous Leukemia)

13 locations incl. Birmingham

Sponsor: Center for International Blood and Marrow Transplant Research

Sex: All·Age: 18 - 66

Code: NCT06859424·Phase 2·Recruiting

Apply to this trial

A Study of Intravenous L-Citrulline in Patients Aged 6-21 Years Old With Sickle Cell Disease Presenting to Emergency Departments in Acute Vaso-Occlusive Crisis

for Sickle Cell Disease

6 locations incl. Washington D.C.

Sponsor: Asklepion Pharmaceuticals, LLC

Sex: All·Age: 6 - 21

Code: NCT06989567·Phase 3·Not Yet Recruiting

Global Open-Label Extension Study of Del-desiran for the Treatment of DM1

for Myotonic Dystrophy Type 1

17 locations incl. Los Angeles

Sponsor: Avidity Biosciences, Inc.

Sex: All·Age: 16+

Code: NCT07008469·Phase 3·Enrolling By Invitation

Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

for Atherosclerotic Cardiovascular Disease

139 locations incl. Daphne

Sponsor: Amgen

Sex: All·Age: 45 - 99

Code: NCT07037433·Phase 3·Recruiting

Apply to this trial

Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Bipolar I Disorder

for Bipolar 1 Disorder

22 locations incl. Little Rock

Sponsor: Rapport Therapeutics Inc.

Sex: All·Age: 18 - 65

Code: NCT07046494·Phase 2·Recruiting

Apply to this trial

Safety and Efficacy of VDPHL01 in Females With Androgenetic Alopecia (AGA)

for Androgenetic Alopecia (AGA)

71 locations incl. Birmingham

Sponsor: Veradermics, Inc.

Sex: Female·Age: 18 - 65

Code: NCT07146022·Phase 3·Recruiting

Apply to this trial

4D Duke Microscope Integrated Optical Coherence Tomography in a Zeiss Artevo 800

for Corneal Diseases

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07024719·Recruiting

Apply to this trial

This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.

for Non-Small Cell Lung Cancer

Drug: sigvotatug vedotin

58 locations incl. Fullerton

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT06758401·Phase 3·Recruiting

Apply to this trial

Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.

for Relapsing Multiple Sclerosis

Drug: Remibrutinib

38 locations incl. Scottsdale

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 40 - 70

Code: NCT06846281·Phase 3·Recruiting

Apply to this trial

Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention

for Percutaneous Coronary Intervention

Drug: Inclisiran

102 locations incl. Alexander City

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06909565·Phase 4·Recruiting

Apply to this trial

Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension

for Pulmonary Hypertension

25 locations incl. Birmingham

Sponsor: Tempus AI

Sex: All·Age: 18+

Code: NCT06911632·Recruiting

Apply to this trial

A Study to Assess Adverse Events and Change in Disease Activity of Oral Surzetoclax Alone or in Combination With Subcutaneous and/or Oral Antimyeloma Agents in Adult Participants With Multiple Myeloma (MM)

for Multiple Myeloma

10 locations incl. Los Angeles

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06953960·Phase 1, Phase 2·Recruiting

Apply to this trial

Study of Lenacapavir as a Once-Yearly Injection for HIV Pre-exposure Prophylaxis (PrEP)

for HIV Pre-exposure Prophylaxis

31 locations incl. Birmingham

Sponsor: Gilead Sciences

Sex: All·Age: 16+·Accepts healthy volunteers

Code: NCT07047716·Phase 3·Recruiting

Apply to this trial

EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease

for Diabetes Mellitus, Type 2

Drug: Empagliflozin

216 locations incl. Anniston

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT07064473·Phase 3·Recruiting

Apply to this trial

Single Intravitreal (IVT) Injection of 4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration

for Neovascular Age-Related Macular Degeneration (nAMD)

54 locations incl. Scottsdale

Sponsor: 4D Molecular Therapeutics

Sex: All·Age: 50+

Code: NCT07064759·Phase 3·Recruiting

Apply to this trial

A Long-Term Follow-Up Observational Study to Evaluate Safety in Subjects Who Have Received a Gene-Modified Regulatory T Cell (Treg) Therapeutic

for Rheumatoid Arthritis (RA)

10 locations incl. San Francisco

Sponsor: Sonoma Biotherapeutics, Inc.

Sex: All·Age: 18 - 71

Code: NCT07123038·Recruiting

Apply to this trial

A Clinical Trial to Evaluate the Safety and Efficacy of COM701 in Relapsed Platinum Sensitive Ovarian Cancer

for Ovarian Cancer

14 locations incl. Augusta

Sponsor: Compugen Ltd

Sex: Female·Age: 18+

Code: NCT06888921·Phase 1, Phase 2·Recruiting

Apply to this trial

Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors

for Pancreatic Neuroendocrine Tumor (pNET)

39 locations incl. Birmingham

Sponsor: Exelixis

Sex: All·Age: 18+

Code: NCT06943755·Phase 2, Phase 3·Recruiting

Apply to this trial

A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)

for Breast Neoplasms

33 locations incl. Daphne

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT07060807·Phase 3·Recruiting

Apply to this trial

Substudy 03C: A Study of Combination Therapies in Participants With Renal Cell Carcinoma With Recurrent Disease During or After Anti-PD-(L)1 Therapy (MK-3475-03C/KEYMAKER-U03)

for Renal Cell Carcinoma

7 locations incl. San Francisco

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18 - 120

Code: NCT07049926·Phase 1, Phase 2·Recruiting

Apply to this trial