OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events

Part of paid clinical trials in Alexander City, Alabama.

Sponsor
Amgen
Study ID
NCT07136012
Phase
PHASE3
Status
Recruiting
Apply to this trial

Conditions

  • Cardiovascular Disease

Eligibility Criteria

Sex
ALL
Age
50 Years - 105 Years
Healthy Volunteers
Not accepted

Interventions

  • Olpasiran — DRUG
    Olpasiran will be administered via SC injection.
  • Placebo — DRUG
    Placebo will be administered via SC injection.

Study Details

The primary objective is to evaluate the effect of olpasiran, compared to placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or urgent coronary revascularization in participants at risk for a first major cardiovascular event with elevated lipoprotein(a) (Lp\[a\]).

Key Dates

Start date
Aug 22, 2025
Status verified
Jun 2026
Primary completion
Oct 20, 2031
Completion
Oct 20, 2031

Study Design

Enrollment
11,000 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Olpasiran
    Participants will receive subcutaneous (SC) olpasiran.
  • Placebo Comparator: Placebo
    Participants will receive SC placebo.

Primary Outcome Measure

Time to CHD Death, Myocardial Infarction, or Urgent Coronary Revascularization, Whichever Occurs First [ Time Frame: Up to approximately 6.2 years ]

Central Contacts

Locations (204)

FacilityCityStateZIPSite coordinators
Advanced Cardiovascular LLCAlexander CityAlabama35010-
Birmingham Clinical ResearchBirminghamAlabama35209-
University of Alabama Birmingham Saint Vincents BirminghamBirminghamAlabama35205-
Alliance For Multispecialty Research - DaphneDaphneAlabama36526-
Eastern Shore Research InstituteFairhopeAlabama36532-
Heart Center Research LLCHuntsvilleAlabama35801-
CB Flock Research CorporationMobileAlabama36608-
Elite Clinical Studies LLCPhoenixArizona85018-
Hero Clinical ResearchPhoenixArizona85021-
Phoenix ClinicalPhoenixArizona85014-
HonorHealth Research InstituteScottsdaleArizona85258-
Eclipse Clinical ResearchTucsonArizona85745-
Lynn Institute of the OzarksLittle RockArkansas72204-
National Heart InstituteBeverly HillsCalifornia90211-
310 Clinical ResearchInglewoodCalifornia90301-
University of California San DiegoLa JollaCalifornia92037-
InvivoCureLos AngelesCalifornia91405-
Valley Clinical TrialsNorthridgeCalifornia91325-
Clinical Trials Research - SacramentoRosevilleCalifornia95661-
Alliance Clinical ResearchSan DiegoCalifornia92120-
Encompass Clinical ResearchSpring ValleyCalifornia91978-
Stanford Health CareStanfordCalifornia94305-
Manshadi Heart InstituteStocktonCalifornia95204-
Blue Coast CardiologyVistaCalifornia92083-
Diablo Clinical ResearchWalnut CreekCalifornia94598-
Focus Clinical ResearchWest HillsCalifornia91307-
Interventional Cardiology Medical GroupWest HillsCalifornia91307-
UCHealth Memorial CentralColorado SpringsColorado80909-
South Denver Cardiology AssociatesLittletonColorado80120-
Gandelman Cardiology, PCGreenwichConnecticut06830-
ClinTrial HamdenHamdenConnecticut06518-
Chase Medical Research LLCWaterburyConnecticut06708-
Excel Medical Clinical TrialsBoca RatonFlorida33434-
Clearwater Cardiovascular ConsultantsClearwaterFlorida33756-
Proactive Clinical ResearchFort LauderdaleFlorida33308-
Elite Cardiac Research Center LLCHialeahFlorida33013-
Indago Research and Health CenterHialeahFlorida33012-
Jacksonville Center for Clinical ResearchJacksonvilleFlorida32216-
East Coast Institute for Research, LLCLake CityFlorida32055-
Columbus Clinical Services LLCMiamiFlorida33125-
Kendall South Medical CenterMiamiFlorida33175-
Inpatient Research Clinic, LLCMiami LakesFlorida33014-
Panax Clinical ResearchMiami LakesFlorida33014-
Eminat, LLCMiramarFlorida33027-
Suncoast Clinical Research IncNew Port RicheyFlorida34652-
Ocala Cardiovascular ResearchOcalaFlorida34471-
Ocala Research Institute, IncOcalaFlorida34474-
Ormond Beach Clinical ResearchOrmond BeachFlorida32174-
Baptist Health CarePensacolaFlorida32514-
Denali Health Plant CityPlant CityFlorida33563-
FWD Clinical ResearchTamaracFlorida33321-
Guardian Research Organization LLCWinter ParkFlorida32792-
Emory University HospitalAtlantaGeorgia30322-
East Coast Institute for ResearchCantonGeorgia30114-
Northeast Georgia Medical Center Wisteria BuildingCummingGeorgia30041-
Nsc ResearchJohns CreekGeorgia30024-
Georgia Clinical ResearchLawrencevilleGeorgia30044-
North Georgia Clinical ResearchWoodstockGeorgia30189-
Solaris Clinical ResearchMeridianIdaho83646-
St Lukes Idaho Cardiology AssociatesMeridianIdaho83642-
Endeavor Health-Northwest Community HealthcareArlington HeightsIllinois60005-
Christie ClinicChampaignIllinois61822-
Advocate Lutheran General HospitalPark RidgeIllinois60068-
Alliance for Multispecialty Research LLC - Park RidgePark RidgeIllinois66068-
MediSphere Medical Research Center LLCEvansvilleIndiana47714-
Parkview Research CenterFort WayneIndiana46845-
Ascension Saint Vincent Heart CenterIndianapolisIndiana46290-
Franciscan Health IndianapolisIndianapolisIndiana46237-
Cardiovascular Research of Northwest Indiana LLCMunsterIndiana46321-
Reid Physician AssociatesRichmondIndiana47374-
MercyOne Iowa Heart CenterWest Des MoinesIowa50266-
Hutchinson Clinic PAHutchinsonKansas67502-
University of Kansas Medical CenterKansas CityKansas66160-
Midwest Heart and Vascular SpecialistsOverland ParkKansas66211-
Graves Gilbert ClinicBowling GreenKentucky42101-
Baptist Health LexingtonLexingtonKentucky40503-
The Research Group of Lexington LLCLexingtonKentucky40503-
Heart Clinic of HammondCovingtonLouisiana70433-
IMA Clinical ResearchMonroeLouisiana71201-
Louisiana Heart CenterSlidellLouisiana70458-
Monroe Research LLCWest MonroeLouisiana71291-
Ascension Saint Agnes Heart CareBaltimoreMaryland21229-
Johns Hopkins HospitalBaltimoreMaryland21287-
Metropolitan Cardiovascular Consultants LLCBeltsvilleMaryland20705-
Suburban HospitalBethesdaMaryland20814-
Flourish ResearchBowieMaryland20715-
Centennial Medical GroupColumbiaMaryland21045-
Johns Hopkins UniversityColumbiaMaryland21044-
Medstar Franklin Square Medical CenterHyattsvilleMaryland20782-
Capitol Cardiology AssociatesLanhamMaryland20706-
Brigham and Womens HospitalBostonMassachusetts02115-
Henry Ford Health SystemDetroitMichigan48202-
Healthy Heart CardiologyGrand RapidsMichigan49546-
MyMichigan Medical Center Midland - Clinical Research DepartmentMidlandMichigan48670-
Advanced Cardiology AssociatesRochester HillsMichigan48307-
Revival Research InstituteSouthfieldMichigan48034-
Saint Marys Medical CenterDuluthMinnesota55805-
Health East Cancer CareMaplewoodMinnesota55109-
University of MinnesotaMinneapolisMinnesota55455-
Mayo ClinicRochesterMinnesota55905-
Methodist HospitalSaint Louis ParkMinnesota55426-
Jackson Heart ClinicJacksonMississippi39216-
Cardiology Associates Research LLCTupeloMississippi38801-
Sisters of Saint Mary Health Heart and Vascular CareBridgetonMissouri63044-
Kansas City Veterans Affairs Medical CenterKansas CityMissouri64128-
Washington UniversitySt LouisMissouri63110-
Bryan HeartLincolnNebraska68506-
Physician Research Collaboration, LLCLincolnNebraska68516-
American Institute of Medical ResearchLas VegasNevada89123-
Excel Clinical ResearchLas VegasNevada89109-
Las Vegas Clinical TrialsNorth Las VegasNevada89030-
Renown Institute for Heart and Vascular HealthRenoNevada89502-
Advanced Heart Care LLCBridgewaterNew Jersey08807-
Advanced Heart and Vascular Institute of HunterdonFlemingtonNew Jersey08822-
Clinical Reseach Philadelphia PenningtonHamiltonNew Jersey08690-
Med Clinical Research Partners - IrvingtonIrvingtonNew Jersey07111-
New Jersey Medcare / New Jersey HeartLindenNew Jersey07036-
Saint Michaels Medical CenterNewarkNew Jersey07102-
Circuit Clinical / Optum Medical Care of New JerseySecaucusNew Jersey07094-
The Heart House - Washington TownshipSewellNew Jersey08080-
CardioMetabolic Collaborative ClinicSomersetNew Jersey08873-
Ima Clinical Research - WarrenWarren TownshipNew Jersey07059-
Albany Medical CollegeAlbanyNew York12203-
Basil ClinicalInwoodNew York11096-
Rasai ResearchJackson HeightsNew York11372-
Crystal Run HealthcareMonroeNew York10950-
Icahn School of Medicine at Mount SinaiNew YorkNew York10029-
Ima Clinical Research ManhattanNew YorkNew York10036-
Mount Sinai QueensNew YorkNew York10029-
Niagara Falls Memorial Medical CenterNiagara FallsNew York14304-
Circuit Clinical Orchard Park Family PracticeOrchard ParkNew York14127-
Hudson Valley Cardiovascular Physicians PCPoughkeepsieNew York12601-
Saratoga Clinical Research, LLCSaratoga SpringsNew York12866-
Duke University Health SystemDurhamNorth Carolina27710-
Medication Management LLCGreensboroNorth Carolina27405-
Moses H Cone Memorial HospitalGreensboroNorth Carolina27401-
Triad Clinical Trials, LLCGreensboroNorth Carolina27410-
ClinCept, LLCKinstonNorth Carolina28501-
Monroe Biomedical ResearchMonroeNorth Carolina28112-
Piedmont HealthcareStatesvilleNorth Carolina28625-
Accellacare Research of WilmingtonWilmingtonNorth Carolina28401-
Wake Forest University Health SciencesWinston-SalemNorth Carolina27157-
Lillestol Research LLCFargoNorth Dakota58104-
Aultman Cardiology Clinical TrialsCantonOhio44710-
The Christ HospitalCincinnatiOhio45219-
Velocity Clinical Research - CincinnatiCincinnatiOhio45219-
Nexgen ResearchLimaOhio45801-
K and R ResearchMarionOhio43302-
Alliance for Multispecialty ResearchNormanOklahoma73069-
University of PennsylvaniaPhiladelphiaPennsylvania19104-
Preferred Primary Care Physicians, IncPittsburghPennsylvania15236-
Pottstown Medical Specialists IncPottstownPennsylvania19464-
Miriam HospitalEast GreenwichRhode Island02818-
Medical University of South CarolinaCharlestonSouth Carolina29425-
Pharmacorp Clinical Trials IncCharlestonSouth Carolina29412-
Prisma Health Carolina Cardiology - GreenvilleGanttSouth Carolina29605-
Walker Family CareLittle RiverSouth Carolina29566-
Accellacare CharlestonMt. PleasantSouth Carolina29464-
Tribe Clinical Research - SpartanburgSpartanburgSouth Carolina29301-
Monument Health Clinical ResearchRapid CitySouth Dakota57701-
Erlanger Health, Inc.ChattanoogaTennessee37403-
Apex Research Foundation, LLCJacksonTennessee38301-
Alliance for Multispecialty Research KnoxvilleKnoxvilleTennessee37909-
Ascension Saint ThomasNashvilleTennessee37205-
Parkway Cardiology AssociatesOak RidgeTennessee37830-
Tennessee Center for Clinical TrialsTullahomaTennessee37388-
PharmaTex Research, LLCAmarilloTexas79106-
Ima Clinical ResearchAustinTexas78745-
Texas Diabetes and EndocrinologyAustinTexas78731-
Pioneer Medical AssociatesCarrolltonTexas75007-
Baylor Scott and White Heart and Vascular Hospital-DallasDallasTexas75226-
Cedar Health Research, LLCDallasTexas75251-
The Heartbeat ClinicDallasTexas75243-
Zenos Clinical ResearchDallasTexas75230-
Cedar Health Research, LLCEulessTexas76040-
Baylor College of MedicineHoustonTexas77030-
Cardiovascular Specialists of WillowbrookHoustonTexas77070-
East Texas Cardiology PAHoustonTexas77002-
Vital Heart and VeinHumbleTexas77338-
Tcr Institute LlcKingwoodTexas77339-
Epic Clinical ResearchLewisvilleTexas75057-
Texas Tech University Health Sciences CenterLubbockTexas79430-
North Dallas Research AssociatesMcKinneyTexas75069-
Revival Research InstituteMcKinneyTexas75071-
Texas Institute of CardiologyMcKinneyTexas75071-
Southern Endocrinology Associates PAMesquiteTexas75149-
Orion MedicalPasadenaTexas77505-
Valley Institute of Research PlanoPlanoTexas75024-
Ima Clinical Research San AntonioSan AntonioTexas78229-
St Davids Heart & Vascular PLLC dba Austin HeartSan MarcosTexas78666-
Tyler Cardiovascular ConsultantsTylerTexas75701-
Alpine Research OrganizationLaytonUtah84041-
Inova Cardiology - FairfaxFairfaxVirginia22031-
Virginia HeartFalls ChurchVirginia22042-
Virginia Heart - LoudounLeesburgVirginia20176-
Carient Heart and VascularManassasVirginia20109-
Bon Secours CardiologyMidlothianVirginia23114-
Tidewater Physicians Multispecialty Group Clinical ResearchNewport NewsVirginia23606-
Alliance for Multispecialty Research NorfolkNorfolkVirginia23502-
Centricity ResearchSuffolkVirginia23435-
Selma Medical AssociatesWinchesterVirginia22601-
Winchester Medical CenterWinchesterVirginia22601-
Western Washington Medical GroupEverettWashington98208-
Rainier Clinical Research CenterRentonWashington98057-

Find similar trials in Alexander City, AL

By research site
Advanced Cardiovascular LLC· Alexander City, ALBirmingham Clinical Research· Birmingham, ALUniversity of Alabama Birmingham Saint Vincents Birmingham· Birmingham, ALAlliance For Multispecialty Research - Daphne· Daphne, ALEastern Shore Research Institute· Fairhope, ALHeart Center Research LLC· Huntsville, AL

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