Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)

Part of paid clinical trials in Gilbert, Arizona.

Sponsor
Eli Lilly and Company
Study ID
NCT07157774
Phase
PHASE3
Status
Recruiting
Apply to this trial

Conditions

  • Atherosclerotic Cardiovascular Disease (ASCVD)
  • Elevated Lp(a)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Muvalaplin — DRUG
    Administered orally
  • Placebo — DRUG
    Administered orally

Study Details

The purpose of this study is to evaluate the efficacy of muvalaplin in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke.

Key Dates

Start date
Sep 2, 2025
Status verified
Jun 2026
Primary completion
Mar 31, 2031
Completion
Mar 31, 2031

Study Design

Enrollment
10,450 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Muvalaplin
    Participants will receive muvalaplin orally.
  • Placebo Comparator: Placebo
    Participants will receive placebo orally.

Primary Outcome Measure

Time to First Occurrence of Any Component of the Major Adverse Cardiac Event (MACE)-4 Composite Endpoint [ Time Frame: Baseline up to End of Study (About 5.25 Years) ]

Central Contacts

  • Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
    1-317-615-4559
    [email protected]
  • Physicians interested in becoming principal investigators please contact
    [email protected]

Locations (121)

FacilityCityStateZIPSite coordinators
Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLCGilbertArizona85296
480-691-2213
Sunildat Maheshwari (PRINCIPAL_INVESTIGATOR)
Axsendo Clinical Research - Peak Heart & Vascular - PhoenixPhoenixArizona85014
602-730-9500
Kevin Berman (PRINCIPAL_INVESTIGATOR)
Clinical Research Institute of Arizona (CRI) - Sun City WestSun City WestArizona85375
623-293-1360
Jalal Abbas (PRINCIPAL_INVESTIGATOR)
Southwest Kidney Institute - SurpriseSurpriseArizona85374
480-610-6100
Minesh Rajpal (PRINCIPAL_INVESTIGATOR)
Pima HeartTucsonArizona85741
5203149254 ex 13563
Mukesh Gopalakrishnan (PRINCIPAL_INVESTIGATOR)
National Heart InstituteBeverly HillsCalifornia90211
310-289-9955
Norman Lepor (PRINCIPAL_INVESTIGATOR)
John Muir Medical Center - Concord CampusConcordCalifornia94520
925-674-2580
Matthew DeVane (PRINCIPAL_INVESTIGATOR)
Neighborhood Healthcare Institute of HealthEscondidoCalifornia92025
760-737-6984
James Schultz (PRINCIPAL_INVESTIGATOR)
Ark Clinical Research - Fountain ValleyFountain ValleyCalifornia92708
714-988-2021
Mark Leibowitz (PRINCIPAL_INVESTIGATOR)
Care Access - Huntington BeachHuntington BeachCalifornia92648
714-378-2440
Christine Thai (PRINCIPAL_INVESTIGATOR)
The Cardiovascular CenterReddingCalifornia96001
281-944-3610
Mohamed Hussein Khan, MD (PRINCIPAL_INVESTIGATOR)
UCLA South Bay EndocrinologyTorranceCalifornia90505
Dianne Cheung (PRINCIPAL_INVESTIGATOR)
University of Colorado Anschutz Medical CampusAuroraColorado80045
303-724-4651
Neda Rasouli (PRINCIPAL_INVESTIGATOR)
Legacy Clinical TrialsColorado SpringsColorado80909
719-387-7572
Charles Bird (PRINCIPAL_INVESTIGATOR)
OptumCare Clinical Trials, LLCGoldenColorado80401-
Cardiology Associates of Fairfield County, P.C.StamfordConnecticut06905
203-353-1133
Edward Portnay (PRINCIPAL_INVESTIGATOR)
Chase Medical Research, LLCWaterburyConnecticut06708
203-419-4420
Joseph Soufer (PRINCIPAL_INVESTIGATOR)
Excel Medical Clinical TrialsBoca RatonFlorida33434
305-631-6704
Michael Hafran (PRINCIPAL_INVESTIGATOR)
FWD Clinical ResearchBoca RatonFlorida33486
561-770-7757
Michael Cammarata (PRINCIPAL_INVESTIGATOR)
American Research InstituteCutler BayFlorida33157
Manuel Garcia Estrada (PRINCIPAL_INVESTIGATOR)
Arrow Clinical TrialsDaytona BeachFlorida32117
386-278-8000
David Billmeier (PRINCIPAL_INVESTIGATOR)
K2 Medical Research - Daytona BeachDaytona BeachFlorida32114
Joshua Eisenhut (PRINCIPAL_INVESTIGATOR)
Soffer Health InstituteHollywoodFlorida33020
Ariel Soffer (PRINCIPAL_INVESTIGATOR)
Jacksonville Center for Clinical ResearchJacksonvilleFlorida32216
904-730-0101
Michael Koren (PRINCIPAL_INVESTIGATOR)
K2 MEDICAL Research THE VILLAGESLady LakeFlorida32159
352-500-5252
Craig Curtis (PRINCIPAL_INVESTIGATOR)
K2 Medical Research - MaitlandMaitlandFlorida32751
407-810-2790
Neel Patel (PRINCIPAL_INVESTIGATOR)
K2 Medical Research ORLANDOMaitlandFlorida32751
407-500-5252
Alfonso Gonzalez-Rodriguez (PRINCIPAL_INVESTIGATOR)
Dade Florida Clinical Research CenterMiamiFlorida33173
786-409-6842
Jesus Gonzalez (PRINCIPAL_INVESTIGATOR)
Onhealth Research CenterMiamiFlorida33186
Jimena Blandon (PRINCIPAL_INVESTIGATOR)
Advanced Research for Health Improvement, LLCNaplesFlorida34102
239-230-2021
Julian Javier (PRINCIPAL_INVESTIGATOR)
Renstar Medical ResearchOcalaFlorida34471
352-629-5800
David Oliver (PRINCIPAL_INVESTIGATOR)
Care Access - TamaracTamaracFlorida33321
877-791-0656
Brad Lipson (PRINCIPAL_INVESTIGATOR)
Care Access - TampaTampaFlorida33625
813-771-5980
Shital Mehta (PRINCIPAL_INVESTIGATOR)
Masters of Clinical ResearchAugustaGeorgia30909
Kashif Naseem (PRINCIPAL_INVESTIGATOR)
Southeastern Clinical Research InstituteAugustaGeorgia30904
706-922-3005
James Stenard (PRINCIPAL_INVESTIGATOR)
Center for Advanced Research & EducationGainesvilleGeorgia30501
770-534-5154
Angela Ritter (PRINCIPAL_INVESTIGATOR)
North Georgia Clinical ResearchWoodstockGeorgia30189
678-494-5735
Bram Wieskopf (PRINCIPAL_INVESTIGATOR)
Elite Clinical TrialsBlackfootIdaho83221
208-643-0006
Gary Soucie (PRINCIPAL_INVESTIGATOR)
CARE Institute - High DesertMeridianIdaho83642
208-398-4306
David Hinchman (PRINCIPAL_INVESTIGATOR)
Elite Clinical TrialsRexburgIdaho83440
208-356-8977
Brian Beesley (PRINCIPAL_INVESTIGATOR)
Great Lakes Clinical Trials - RavenswoodChicagoIllinois60640
773-275-3500
Manish Jain (PRINCIPAL_INVESTIGATOR)
AMR ClinicalNilesIllinois60714
Saifullah Nasir (PRINCIPAL_INVESTIGATOR)
IU Health BloomingtonBloomingtonIndiana47408
Julie Clary (PRINCIPAL_INVESTIGATOR)
Indiana University Health Methodist HospitalIndianapolisIndiana46202
Julie Clary (PRINCIPAL_INVESTIGATOR)
Tulane University School of MedicineNew OrleansLouisiana70112
504-756-5621
Keith Ferdinand (PRINCIPAL_INVESTIGATOR)
MaineHealth CardiologyScarboroughMaine04074
Edward Teufel (PRINCIPAL_INVESTIGATOR)
Ascension Saint Agnes Heart CareBaltimoreMaryland21229
443-798-2670
Jeffrey Cole (PRINCIPAL_INVESTIGATOR)
Metropolitan Cardiovascular ConsultantsBeltsvilleMaryland20750
301-595-0356
Ayim Akyea-Djamson (PRINCIPAL_INVESTIGATOR)
Flourish Research - BowieBowieMaryland20715
410-824-1342
BARBARA HUTCHINSON (PRINCIPAL_INVESTIGATOR)
Centennial Medical GroupColumbiaMaryland21045
410-730-3399
Rajiv Dua (PRINCIPAL_INVESTIGATOR)
Johns Hopkins UniversityColumbiaMaryland21044
Daniel Kim (PRINCIPAL_INVESTIGATOR)
Anderson Medical ResearchFt. WashingtonMaryland20744
301-542-6741
Felton Anderson (PRINCIPAL_INVESTIGATOR)
Brigham and Women's Hospital Diabetes ProgramBostonMassachusetts02115
617-732-4245
Vanita Aroda (PRINCIPAL_INVESTIGATOR)
Lucida Clinical TrialsNew BedfordMassachusetts02740
Maria Rumsey (PRINCIPAL_INVESTIGATOR)
Care Access - QuincyQuincyMassachusetts02169
877-791-0656
Chih Chao Yang (PRINCIPAL_INVESTIGATOR)
Revival Research Institute, LLCDearbornMichigan48126
Qaiser Shafiq (PRINCIPAL_INVESTIGATOR)
Arcturus Healthcare , PLC, Troy Internal Medicine Research DivisionTroyMichigan48098
248-312-0025
Neil Fraser (PRINCIPAL_INVESTIGATOR)
Boeson Research MSOMissoulaMontana59804
406-763-8833
Aubrey Remmers (PRINCIPAL_INVESTIGATOR)
Clinical Research of South NevadaLas VegasNevada89121
702-570-6107
Roger Estevez (PRINCIPAL_INVESTIGATOR)
Vector Clinical TrialsLas VegasNevada89128
702-750-000
Bharat Mocherla (PRINCIPAL_INVESTIGATOR)
Vector Clinical TrialsSparksNevada89436
775-877-9777
Nitesh Kuhadiya (PRINCIPAL_INVESTIGATOR)
Clinical Research of PhiladelphiaPenningtonNew Jersey08534
215-676-6696
Taher Modarressi (PRINCIPAL_INVESTIGATOR)
Cardio Metabolic InstituteSomersetNew Jersey08873
732-846-7000 x 108
Dinesh Singal (PRINCIPAL_INVESTIGATOR)
IMA Clinical ResearchAlbuquerqueNew Mexico87109
505-848-3773
Yaw Adjei-Poku (PRINCIPAL_INVESTIGATOR)
Southwest Cardiovascular CenterAlbuquerqueNew Mexico87112
Suresh Neelagaru (PRINCIPAL_INVESTIGATOR)
Capital Cardiology AssociatesAlbanyNew York12211
518-292-6216
Lance Sullenberger (PRINCIPAL_INVESTIGATOR)
NYC ResearchNew YorkNew York10016
516-574-9232
Anastasios Manessis (PRINCIPAL_INVESTIGATOR)
Weill Cornell Medical CollegeNew YorkNew York10021
646-962-5558
Samuel Kim (PRINCIPAL_INVESTIGATOR)
Rochester Clinical Research, LLCRochesterNew York14609
585-288-0890
Matthew Davis (PRINCIPAL_INVESTIGATOR)
SUNY Upstate Medical UniversitySyracuseNew York13210
315-464-9006
Malek El Muayed (PRINCIPAL_INVESTIGATOR)
Southgate Medical GroupWest SenecaNew York14224
716-712-1004
Brian Snyder (PRINCIPAL_INVESTIGATOR)
Care Access - FayettevilleFayettevilleNorth Carolina28314
910-249-9855
Daniel Uba (PRINCIPAL_INVESTIGATOR)
Medication ManagementGreensboroNorth Carolina27405
336-763-6968
James Franklin (PRINCIPAL_INVESTIGATOR)
Kaiser Permanente Sunnyside Medical CenterClackamasOregon97015
Abhimanyu Uberoi (PRINCIPAL_INVESTIGATOR)
Advanced Research Institute - TigardTigardOregon97223
503-610-0033
James Bergthold (PRINCIPAL_INVESTIGATOR)
Lehigh Valley Health NetworkAllentownPennsylvania18103
610-402-9543
Andrew Sumner (PRINCIPAL_INVESTIGATOR)
Capital Area Research, LLCCamp HillPennsylvania17011
717-441-1725
Venkatesh Nadar (PRINCIPAL_INVESTIGATOR)
Altoona Center For Clinical ResearchDuncansvillePennsylvania16635
814-693-0300
Alan Kivitz (PRINCIPAL_INVESTIGATOR)
Clinical Research of PhiladelphiaPhiladelphiaPennsylvania19114
215-676-6696
JOSEPH HEETHER (PRINCIPAL_INVESTIGATOR)
Penn Medicine: University of Pennsylvania Health SystemPhiladelphiaPennsylvania19104
Archna Bajaj (PRINCIPAL_INVESTIGATOR)
Keystone Clinical StudiesPlymouth MeetingPennsylvania19462
610-277-8073
Stephen Litman (PRINCIPAL_INVESTIGATOR)
M3 Wake Research - CharlestonCharlestonSouth Carolina29414
843-258-1852
Donald Hurley (PRINCIPAL_INVESTIGATOR)
Medical University of South CarolinaCharlestonSouth Carolina29425
Ashley Waring (PRINCIPAL_INVESTIGATOR)
Walker Family CareLittle RiverSouth Carolina29566
843-280-8333
Stephen Grubb (PRINCIPAL_INVESTIGATOR)
Circle Clinical ResearchSioux FallsSouth Dakota57104
605-215-1159
Elizabeth Jensen (PRINCIPAL_INVESTIGATOR)
WR-Clinsearch, LLCChattanoogaTennessee37397
423-698-4584
Obadias Marquez (PRINCIPAL_INVESTIGATOR)
The Jackson ClinicJacksonTennessee38305
731-660-8396
Edwin Hays (PRINCIPAL_INVESTIGATOR)
PharmaTex ResearchAmarilloTexas79106
806-355-2581
David Brabham (PRINCIPAL_INVESTIGATOR)
St. David's Heart & Vascular PLLC dba Austin HeartAustinTexas78756
Kunjan Bhatt (PRINCIPAL_INVESTIGATOR)
Dallas VA Medical CenterDallasTexas75216
214-857-0393
Kyaw Soe (PRINCIPAL_INVESTIGATOR)
IntraCareDallasTexas75254
972-385-0000
Shakil Ahmed (PRINCIPAL_INVESTIGATOR)
Renal Disease Research InstituteDallasTexas75246
214-366-6125
Bernard Fischbach (PRINCIPAL_INVESTIGATOR)
Southwest Family Medicine AssociatesDallasTexas75235
469-893-1242
Chrisette Dharma (PRINCIPAL_INVESTIGATOR)
UT Southwestern Medical CenterDallasTexas75390
Parag Joshi (PRINCIPAL_INVESTIGATOR)
Cedar Health Research - Fort WorthFort WorthTexas76132
214-253-8170
Olutola Adetona (PRINCIPAL_INVESTIGATOR)
Texas Health Research & Education Institute - Fort WorthFort WorthTexas76104
817-252-5000
Tyler Bloomer (PRINCIPAL_INVESTIGATOR)
Center for Cardiometabolic Disease Prevention/Baylor College of MedicineHoustonTexas77030
713-798-5800
Christie Ballantyne (PRINCIPAL_INVESTIGATOR)
Research Physicians Network, LLCHoustonTexas77089
281-944-3610
Amir Hassan (PRINCIPAL_INVESTIGATOR)
GMG Clinical Research (DBA Radiance Clinical Research) - LampasasLampasasTexas76550
512-556-4130
Vanna Gold (PRINCIPAL_INVESTIGATOR)
Biopharma Informatic, LLCMcAllenTexas78503
281-944-3610
Christian Assad-Kottner (PRINCIPAL_INVESTIGATOR)
Revival Research Institute, LLCMcKinneyTexas75071
Asad Karim (PRINCIPAL_INVESTIGATOR)
PRX ResearchMesquiteTexas75149
972-777-4428
Urooj Shibli (PRINCIPAL_INVESTIGATOR)
ERA Health Research-TexasMidlandTexas79707
432-528-7555
Sapna Chilka (PRINCIPAL_INVESTIGATOR)
Sherman Clinical ResearchShermanTexas75090
903-771-4093
Nikhil Joshi (PRINCIPAL_INVESTIGATOR)
Intermountain Medical CenterMurrayUtah84107
Kirk Knowlton (PRINCIPAL_INVESTIGATOR)
Advanced Research InstituteOgdenUtah84405
801-409-2040
Michael Woolman (PRINCIPAL_INVESTIGATOR)
Ogden Clinic - Canyon ViewOgdenUtah84404
385-271-0684
Stephen Bruce (PRINCIPAL_INVESTIGATOR)
Virginia HeartFalls ChurchVirginia22042
703-766-5920
Tariq Haddad (PRINCIPAL_INVESTIGATOR)
Mary Washington HospitalFredericksburgVirginia22401
Sebhat Erqou (PRINCIPAL_INVESTIGATOR)
Carient Heart & Vascular - ManassasManassasVirginia20109
703-335-8750
Hamid Taheri (PRINCIPAL_INVESTIGATOR)
Manassas Clinical Research CenterManassasVirginia20110
703-330-1112
Nabil Andrawis (PRINCIPAL_INVESTIGATOR)
TPMG (Tidewater Physicians Multispecialty Group) Clinical ResearchNewport NewsVirginia23606
757-232-8836
Linda Schneider (PRINCIPAL_INVESTIGATOR)
York Clinical ResearchNorfolkVirginia23504
757-373-8478
Charles Lovell (PRINCIPAL_INVESTIGATOR)
Dominion Medical Associates, Inc.RichmondVirginia23219
804-249-2111
Richard Jackson (PRINCIPAL_INVESTIGATOR)
Carilion ClinicRoanokeVirginia24014
Bryant Self (PRINCIPAL_INVESTIGATOR)
ERA Health Research - CardioNow - LynnwoodLynnwoodWashington98036
425-869-6828
Kevin Hanson (PRINCIPAL_INVESTIGATOR)
Eastside Research AssociatesRedmondWashington98052
425-869-6828
Christopher Price (PRINCIPAL_INVESTIGATOR)
Rainier Clinical Research CenterRentonWashington98057
425-251-1722
Sheryl Marks (PRINCIPAL_INVESTIGATOR)
Universal Research GroupTacomaWashington98405
253-882-1070
Sabrina Benjamin (PRINCIPAL_INVESTIGATOR)
Central Washington Health Services Association d/b/a Confluence HealthWenatcheeWashington98801
509-436-4050
Kathryn Eren (PRINCIPAL_INVESTIGATOR)
Clinical Investigation SpecialistsKenoshaWisconsin53144
262-925-1280
John Agaiby (PRINCIPAL_INVESTIGATOR)

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