Paid Clinical Trials in Massachusetts

Massachusetts has 3,584 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 16, 2026.

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3,586 clinical trials

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Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

for Treatment Resistant Depression

24 locations incl. Birmingham

Sponsor: Abbott Medical Devices

Sex: All·Age: 22 - 70

Code: NCT06423430·Recruiting

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A Phase II Study of Ensifentrine in Non-Cystic Fibrosis Bronchiectasis

for Non-cystic Fibrosis Bronchiectasis

29 locations incl. Birmingham

Sponsor: Verona Pharma, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA

Sex: All·Age: 18 - 80

Code: NCT06559150·Phase 2·Recruiting

Apply to this trial

AVAVA MIRIA General Use

for Acne

1 location in Waltham

Sponsor: AVAVA, Inc.

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT06868615·Recruiting

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The Effects of Psilocybin on Self-Focus and Self-Related Processing in Major Depressive Disorder

for Major Depressive Disorder

1 location in Charlestown

Sponsor: Sharmin Ghaznavi

Sex: All·Age: 18 - 55

Code: NCT06247839·Phase 3·Recruiting

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PROSTATE-IQ: Parallel RandOmized STudy of Personalized Apalutamide Treatment and Evaluation to Improve Quality of Life in Post-Operative Radiation With Androgen Axis Suppression. A Phase III Multi-center Study for Men With Detectable PSA After Prostatectomy for Prostate Cancer.

for Androgen Axis Suppression

Drug: Apalutamide

5 locations incl. Chicago

Sponsor: M.D. Anderson Cancer Center

Sex: Male·Age: 18+

Code: NCT06274047·Phase 3·Recruiting

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LIFT: Life Improvement Trial

for ME/CFS

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 70

Code: NCT06366724·Phase 2·Recruiting

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Head-Cancelled Virtual Reality for Ocular Cranial Nerve Palsies

for Internuclear Ophthalmoplegia

2 locations incl. Jacksonville

Sponsor: Kevin Houston

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06417216·Recruiting

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Study of Oral Ubrogepant to Assess Adverse Events and Change in Disease Activity in Adult Participants With Menstrual Migraine

for Migraine

Drug: Ubrogepant

103 locations incl. Birmingham

Sponsor: AbbVie

Sex: Female·Age: 18+

Code: NCT06417775·Phase 3·Recruiting

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Prolonged Overnight Fasting and/or Exercise on Fatigue and Other Patient Reported Outcomes in Women With Hormone Receptor Positive Advanced Breast Cancer

for HER2-positive Breast Cancer

3 locations incl. Phoenix

Sponsor: University of Miami

Sex: Female·Age: 18+

Code: NCT06123988·Recruiting

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Safety and Effectiveness of Mechanical Thrombectomy Using the Anaconda ANA Funnel Catheter

for Acute Ischemic Stroke From Large Vessel Occlusion

11 locations incl. Jacksonville

Sponsor: Anaconda Biomed S.L.

Sex: All·Age: 22 - 85

Code: NCT06370182·Recruiting

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A Study of Vemurafenib and Obinutuzumab Compared to Cladribine and Rituximab in People With Hairy Cell Leukemia (HCL)

for Hairy Cell Leukemia

Drug: Rituximab

10 locations incl. Boston

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT06561360·Phase 2·Recruiting

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Safety and Efficacy of Matrix Pro for Eyebrow Lift and Lift of Submental/Neck Laxity

for Laxity

1 location in Marlborough

Sponsor: Candela Corporation

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT06640998·Enrolling By Invitation

Long-term Follow-up of Participants Treated With Galapagos Chimeric Antigen Receptor (CAR) T-cell Therapies

for Hematological Malignancies

1 location in Boston

Sponsor: Lakefront Biotherapeutics NV

Sex: All·Age: 18+

Code: NCT06652633·Phase 3·Recruiting

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A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH

for NASH - Nonalcoholic Steatohepatitis

Drug: Efruxifermin

168 locations incl. Birmingham

Sponsor: Akero Therapeutics, Inc

Sex: All·Age: 18 - 80

Code: NCT06528314·Phase 3·Recruiting

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Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease

for Crohn's Disease

64 locations incl. Dothan

Sponsor: AbbVie

Sex: All·Age: 18 - 75

Code: NCT06548542·Phase 2·Recruiting

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A Study of Rapcabtagene Autoleucel in Active, Refractory Systemic Lupus Erythematosus (SLE) or Lupus Nephritis (LN) Patients (AUTOGRAPH - SLE/LN)

for Lupus Erythematosus, Systemic

19 locations incl. Birmingham

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 75

Code: NCT06581198·Phase 2·Recruiting

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A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)

for Pulmonary Hypertension

31 locations incl. Phoenix

Sponsor: Tectonic Therapeutic

Sex: All·Age: 18 - 83

Code: NCT06616974·Phase 2·Recruiting

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The Coronary Artery Calcium and Troponins in Rheumatoid Arthritis (CAT-RA) Study

for Rheumatoid Arthritis (RA

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 35 - 79

Code: NCT07315997·Recruiting

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Prospective Multicenter Research on Donor and Recipient Management Strategies to Improve Lung Transplant Outcomes

for Lung Transplant

18 locations incl. Los Angeles

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06399302·Recruiting

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PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm

for Coronary Artery Disease

18 locations incl. Chandler

Sponsor: Kardion Inc

Sex: All·Age: 18 - 90

Code: NCT06445608·Recruiting

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Robotic Apparel to Prevent Freezing of Gait in Parkinson Disease

for Parkinson Disease (PD)

2 locations incl. Allston

Sponsor: Harvard Medical School (HMS and HSDM)

Sex: All·Age: 18 - 90

Code: NCT06602544·Recruiting

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Frequency of Selected Single Nucleotide Polymorphisms in Huntington Disease Gene Expansion Carriers

for Huntington Disease

13 locations incl. Birmingham

Sponsor: Hoffmann-La Roche

Sex: All·Age: 25 - 60

Code: NCT06667414·Recruiting

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Cognitive Control to Boost Physical Activity Adherence

for Physical Inactivity

2 locations incl. Iowa City

Sponsor: University of Iowa

Sex: All·Age: 40 - 65·Accepts healthy volunteers

Code: NCT06338774·Recruiting

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The COMPASSION Study

for Breast Cancer

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06507930·Recruiting

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CRS Questionnaire Validation Project

for Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps

5 locations incl. Santa Monica

Sponsor: The European Forum for Research and Education in Allergy and Airway Diseases

Sex: All·Age: 18+

Code: NCT06970977·Recruiting

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Episodic Memory Integration and Interference

for Episodic Memory

1 location in Chestnut Hill

Sponsor: Boston College

Sex: All·Age: 18 - 39·Accepts healthy volunteers

Code: NCT05974371·Not Yet Recruiting

A Multicenter Phase 1b/2 Study of Adagrasib, Cetuximab, and Cemiplimab for Metastatic Colorectal Cancer Harboring KRAS G12C Mutations

for Metastatic Colorectal Cancer

Drug: Cemiplimab

2 locations incl. Boston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06412198·Phase 1, Phase 2·Recruiting

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A Study to Learn More About How Well Sevabertinib Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

for Advanced Non-small Cell Lung Cancer, HER2 Mutation

27 locations incl. Newport Beach

Sponsor: Bayer

Sex: All·Age: 18+

Code: NCT06452277·Phase 3·Recruiting

Apply to this trial

Open Label Extension Study of NCT06221852

for Bipolar I Disorder

1 location in Belmont

Sponsor: Mclean Hospital

Sex: All·Age: 18 - 45

Code: NCT06558201·Enrolling By Invitation

Optimal Duration of Foley Catheter After Bulbar Urethroplasty

for Urethral Stricture, Bulbar

4 locations incl. Burlington

Sponsor: Jane Kurtzman

Sex: Male·Age: 18 - 70

Code: NCT07220980·Enrolling By Invitation

Skilled Nursing Facility at Home Trial

for Skilled Nursing Facility

2 locations incl. Springfield

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: 18+

Code: NCT06547645·Recruiting

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A Study Comparing Anitocabtagene Autoleucel to Standard of Care Therapy in Participants With Relapsed/ Refractory Multiple Myeloma

for Multiple Myeloma

50 locations incl. Gilbert

Sponsor: Kite, A Gilead Company

Sex: All·Age: 18+

Code: NCT06413498·Phase 3·Recruiting

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Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

for High Grade Glioma

Drug: Ribociclib

11 locations incl. Aurora

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 12 Months - 39

Code: NCT05843253·Phase 2·Recruiting

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Study to Assess Safety and Tolerability of OPN-6602 in Subjects With Relapsed and/or Refractory Multiple Myeloma

for Relapsed Multiple Myeloma

12 locations incl. Gilbert

Sponsor: Opna Bio LLC

Sex: All·Age: 18+

Code: NCT06433947·Phase 1·Recruiting

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Phase 3 Study on the Efficacy and Safety of Human Plasma Derived Antithrombin (Atenativ) in Heparin-Resistant Patients Scheduled to Undergo Cardiac Surgery Necessitating Cardiopulmonary Bypass

for Acquired Antithrombin Deficiency

9 locations incl. Stanford

Sponsor: Octapharma

Sex: All·Age: 18 - 85

Code: NCT06096116·Phase 3·Recruiting

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A Study to Test the Efficacy and Safety of Riliprubart Against the Usual Treatment of Intravenous Immunoglobulin (IVIg) in People With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

for Chronic Inflammatory Demyelinating Polyneuropathy

Drug: riliprubart

31 locations incl. Homewood

Sponsor: Sanofi

Sex: All·Age: 18+

Code: NCT06290141·Phase 3·Recruiting

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Neural Mechanisms of Family-Focused Treatment for Youth Depression

for Childhood Depression

2 locations incl. Boston

Sponsor: Boston University Charles River Campus

Sex: All·Age: 7 - 12·Accepts healthy volunteers

Code: NCT06289010·Recruiting

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PICNIC Study - PatIent Centered aNtIbiotic Courses in Children With Medical Complexity

for Pneumonia

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 2 - 25

Code: NCT06364514·Recruiting

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A Clinical Trial of Combination HIV-Specific Broadly Neutralizing Monoclonal Antibodies Combined With ART Initiation During Acute HIV Infection to Induce HIV Remission

for Acute HIV Infection

32 locations incl. Birmingham

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 70

Code: NCT05719441·Phase 2·Recruiting

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Study of Safety and Efficacy of RGT-61159 in Adults With Relapsed/Refractory Adenoid Cystic Carcinoma (ACC) or Colorectal Carcinoma (CRC)

for Adenoid Cystic Carcinoma

8 locations incl. Boston

Sponsor: Rgenta Therapeutics Inc

Sex: All·Age: 18+

Code: NCT06462183·Phase 1·Recruiting

Apply to this trial