PICNIC Study - PatIent Centered aNtIbiotic Courses in Children With Medical Complexity

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Boston Children's Hospital
Study ID
NCT06364514
Status
Recruiting
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Conditions

  • Pneumonia

Eligibility Criteria

Sex
ALL
Age
2 Years - 25 Years
Healthy Volunteers
Not accepted

Interventions

  • Clinical Stability Assessment — OTHER
    Base total days of antibiotics on clinical stability vs utilizing predetermined total days of antibiotics

Study Details

To determine if clinicians can safely reduce antibiotic exposure in children with medical complexity (CMC) who are diagnosed with pneumonia by implementing an intervention that bases total antibiotic duration on an individual's clinical stability.

Key Dates

Start date
Aug 20, 2024
Status verified
Nov 2025
Primary completion
Jun 1, 2026
Completion
Oct 1, 2026

Study Design

Enrollment
50 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Intervention Group
    Patients will be started on antibiotics for treatment of pneumonia per usual care by their medical provider team. The research team will monitor enrolled patients daily for markers of their clinical status (caregiver assessment of respiratory status, supplemental oxygen/respiratory support, presence of fever). Once the patient has been "clinically stable" x48 hours, antibiotics will be discontinued.

Primary Outcome Measure

Proportion of eligible patients who consent to participate in the intervention [ Time Frame: 48 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Boston Children's HospitalBostonMassachusetts02115
Kathleen D Snow, MD, MPH
[email protected]

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By research site
Boston Children's Hospital· Boston, MA

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