Paid Clinical Trials in Massachusetts

Massachusetts has 3,584 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 16, 2026.

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3,586 clinical trials

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Texting to Reduce Human Immunodeficiency Virus (HIV) Risk

for HIV Infections

2 locations incl. Boston

Sponsor: Boston University

Sex: All·Age: 18+

Code: NCT06088277·Recruiting

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Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)

for B-cell Acute Lymphoblastic Leukemia

17 locations incl. Los Angeles

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 6 Months - 25

Code: NCT06395103·Phase 1, Phase 2·Recruiting

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A Prospective Study on the Role of Karl Storz Curved and Straight Fetoscopes (11508AAK and 11506AAK) for Fetoscopic Intrauterine Procedures

for Fetal Conditions

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: Female·Age: 18 - 45

Code: NCT06056635·Recruiting

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A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease

for Alzheimer Disease

6 locations incl. Maitland

Sponsor: Eli Lilly and Company

Sex: All·Age: 50 - 85

Code: NCT06297590·Phase 1·Recruiting

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Promoting Improved Functioning Among People Experiencing Stressful Situations

for Acute Stress Reaction

5 locations incl. Belmont

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 50

Code: NCT06482567·Recruiting

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A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease

for Sickle Cell Disease

5 locations incl. Birmingham

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 12 - 55·Accepts healthy volunteers

Code: NCT06546670·Phase 1, Phase 2·Recruiting

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A Study to Evaluate Solrikitug in Participants With COPD (ZION)

for COPD

101 locations incl. Birmingham

Sponsor: Uniquity One (UNI)

Sex: All·Age: 40 - 75

Code: NCT06496620·Phase 2·Recruiting

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Safety/Efficacy Study of CID-078 in Patients With Advanced Solid Tumor Malignancies

for Advanced Solid Tumor

10 locations incl. Sarasota

Sponsor: Circle Pharma

Sex: All·Age: 12+

Code: NCT06577987·Phase 1·Recruiting

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A Study Comparing the Efficacy and Safety of Zanidatamab to Trastuzumab, Each in Combination With Physician's Choice Chemotherapy, for the Treatment of Participants With Metastatic HER2-positive Breast Cancer

for Metastatic HER2-positive Breast Cancer

48 locations incl. Phoenix

Sponsor: Jazz Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06435429·Phase 3·Recruiting

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Phase Ib Study of Axatilimab in Combination With Olaparib in BRCA1/2 and PALB2- Associated Metastatic HER2-negative Breast Cancer

for Breast Cancer

3 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06488378·Phase 1·Recruiting

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A Single-Center Study to Characterize the Safety and Efficacy of Ublituximab in Older Adults With Relapsing Forms of Multiple Sclerosis (RMS)

for Multiple Sclerosis, Relapsing Forms of Multiple Sclerosis

1 location in Foxborough

Sponsor: Neurology Center of New England P.C.

Sex: All·Age: 55 - 80

Code: NCT06681623·Recruiting

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Best Practice Advisories to Reduce Inequities in Technology Use for People With Type 1 Diabetes

for Diabetes Mellitus, Type 1

2 locations incl. Boston

Sponsor: T1D Exchange, United States

Sex: All·Age: 2 - 95·Accepts healthy volunteers

Code: NCT06931275·Recruiting

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Synbiotic to Attenuate Resorption of the Skeleton

for Osteoporosis

1 location in Roslindale

Sponsor: Hebrew SeniorLife

Sex: Female·Age: 60+·Accepts healthy volunteers

Code: NCT06389539·Recruiting

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Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer

for Biliary Tract Cancer

Drug: Rilvegostomig

48 locations incl. Scottsdale

Sponsor: AstraZeneca

Sex: All·Age: 18 - 99

Code: NCT06467357·Phase 3·Recruiting

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Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

for Recurrent Lung Non-Small Cell Carcinoma

266 locations incl. Daphne

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18 Minutes+

Code: NCT06031688·Phase 2·Recruiting

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Crohn's Disease: Efficacy, Safety, and Pharmacokinetics of Upadacitinib in Pediatric Subjects With Moderately to Severely Active Crohn's Disease

for Crohn's Disease

Drug: Upadacitinib

12 locations incl. Oakland

Sponsor: AbbVie

Sex: All·Age: 2 - 17

Code: NCT06332534·Phase 3·Recruiting

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The SAPPHO Study: Sequential Therapy With Curative Intent in de Novo HER2+ Metastatic Breast Cancer

for Breast Cancer Female

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06439693·Phase 2·Recruiting

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Autologous iPSC-Derived Dopamine Neuron Transplantation for Parkinson's Disease

for Parkinson Disease

1 location in Boston

Sponsor: Penelope J. Hallett, Ph.D.

Sex: All·Age: 55 - 80

Code: NCT06422208·Phase 1·Enrolling By Invitation

Neurofibromatosis Type 1 Tumor Early Detection Study

for Neurofibromatosis Type 1

1 location in Boston

Sponsor: David Miller

Sex: All·Age: 18+

Code: NCT06515860·Recruiting

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Characterization And Clinical Outcomes of AA Patients Treated With Ritlecitinib

for Alopecia Areata

Drug: Ritlecitinib

25 locations incl. Montgomery

Sponsor: Pfizer

Sex: All·Age: 12+

Code: NCT06531109·Recruiting

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A Study of Surovatamig (AZD0486) Plus Rituximab in Previously Untreated Follicular Lymphoma Patients

for Untreated Follicular Lymphoma

Drug: Rituximab

51 locations incl. Huntsville

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06549595·Phase 3·Recruiting

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Mobile Application to Improve Health-Related Outcomes in Patients With Advanced Lung Cancer

for Lung Cancer

3 locations incl. Los Angeles

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06427954·Recruiting

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Developing Restful Environments and Management Strategies for Pediatric Stem Cell Transplant Patients

for Stem Cell Transplant Complications

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 9 - 17

Code: NCT06468618·Recruiting

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A Study to Learn if 27T51, a Mucin-16 (MUC16) Protein Targeting Immune Cell Therapy, Administered Alone or in Combination is Safe and How Well it Works for Adult Participants With Recurrent or Treatment Resistant Ovarian Cancers

for Epithelial Ovarian Cancer

5 locations incl. Boston

Sponsor: Regeneron Pharmaceuticals

Sex: Female·Age: 18+

Code: NCT06469281·Phase 1·Recruiting

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Study Evaluating Dosimetry, Randomized Dose Optimization, Dose Escalation and Efficacy of Ac-225 Rosopatamab Tetraxetan in Participants With PSMA PET-Positive Castration-Resistant Prostate Cancer (CRPC)

for PSMA PET-Positive Castration-Resistant Prostate Cancer

9 locations incl. San Diego

Sponsor: Convergent Therapeutics

Sex: Male·Age: 18+

Code: NCT06549465·Phase 2·Recruiting

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A Study to Evaluate the Risk of Tumor Lysis Syndrome (TLS) in Adult Participants Receiving Oral Venetoclax in Combination With Intravenously Infused Obinutuzumab or Oral Acalabrutinib for Previously Untreated Chronic Lymphocytic Leukemia (CLL)

for Chronic Lymphocytic Leukemia

Drug: Venetoclax

32 locations incl. Tucson

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06428019·Phase 3·Recruiting

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Study of ITI-1284 as an Adjunctive Treatment in Patients With Generalized Anxiety Disorder

for Generalized Anxiety Disorder

34 locations incl. Chandler

Sponsor: Intra-Cellular Therapies, Inc.

Sex: All·Age: 18+

Code: NCT06480383·Phase 2·Recruiting

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Targeted Pediatric High-Grade Glioma Therapy

for High Grade Glioma

11 locations incl. Aurora

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 12 Months - 39

Code: NCT05839379·Recruiting

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BetterLife FSHD: A Patient-driven Health and Research Platform

for FSH

1 location in Randolph

Sponsor: FSHD Society

Sex: All·Age: 1+

Code: NCT07409142·Recruiting

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Multi-Arm Multi-Stage Adaptive Platform Trial (APT) for the Acute Treatment of Traumatic Brain Injury

for Traumatic Brain Injury

18 locations incl. San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 18 - 65

Code: NCT05826912·Phase 2·Enrolling By Invitation

A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)

for Head and Neck Squamous Cell Carcinoma

29 locations incl. Duarte

Sponsor: Tempus AI

Sex: All·Age: 18+

Code: NCT06163534·Recruiting

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Connectomic Targeted TMS Target for Refractory Anxiety

for Anxiety Disorders

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 70

Code: NCT06376877·Phase 2·Not Yet Recruiting

Saruparib (AZD5305) Plus Camizestrant Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer

for Advanced Breast Cancer

Drug: Camizestrant

54 locations incl. Gilbert

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06380751·Phase 3·Recruiting

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DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes

for Gestational Diabetes Mellitus

21 locations incl. Tuscaloosa

Sponsor: Ohio State University

Sex: Female·Age: 18+

Code: NCT06445946·Phase 4·Recruiting

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Yoga Breath Training to Improve Cardiorespiratory Synchrony in Spinal Cord Injury

for Spinal Cord Injuries

1 location in Cambridge

Sponsor: Spaulding Rehabilitation Hospital

Sex: All·Age: 18 - 60

Code: NCT06514950·Recruiting

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Our Whole Lives Gemini: Virtual Integrative Medical Group Visits for Managing Chronic Pain

for Chronic Pain

1 location in Malden

Sponsor: Cambridge Health Alliance

Sex: All·Age: 18+

Code: NCT06515925·Recruiting

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Studying Solriamfetol Modulation of TAAR-1, Dopamine, and Norepinephrine in Shift Work Disorder (SUSTAIN)

for Excessive Sleepiness

Drug: Solriamfetol

38 locations incl. Cullman

Sponsor: Axsome Therapeutics, Inc.

Sex: All·Age: 18 - 65

Code: NCT06568367·Phase 3·Recruiting

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Use of Indocyanine Green (ICG) for the Diagnosis of Biliary Atresia

for Biliary Atresia

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 0 Days - 3 Months

Code: NCT07513038·Phase 1, Phase 2·Recruiting

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BE WELL With Migraine: Brain Education and WELLness With Migraine

for Migraine

3 locations incl. Cambridge

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT05987592·Recruiting

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Assessing the Efficacy of an Acceptance-Based Digital Intervention for Veterans With Chronic Pain

for Chronic Pain

3 locations incl. West Haven

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT06058624·Recruiting

Apply to this trial