Paid Clinical Trials in Massachusetts

Massachusetts has 3,586 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 16, 2026.

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3,586 clinical trials

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Cerebellar Modulation of Cognition in Psychosis

for Schizophrenia

2 locations incl. Belmont

Sponsor: Mclean Hospital

Sex: All·Age: 18 - 55

Code: NCT06107764·Recruiting

Apply to this trial

A Phase 1, Dose-escalation Study of [225Ac]-FPI-2068 in Adult Patients With Advanced Solid Tumours

for Advanced Solid Tumor

11 locations incl. Irvine

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06147037·Phase 1·Recruiting

Apply to this trial

Harness-based Mobility Intervention for Infants With Down Syndrome

for Down Syndrome

1 location in Boston

Sponsor: Boston University Charles River Campus

Sex: All·Age: Up to 2

Code: NCT06219863·Recruiting

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AI Detection of Incidental Coronary Artery Calcium to Enhance Cardiovascular Disease Prevention

for Coronary Artery Disease

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 40 - 75

Code: NCT06235112·Recruiting

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Long-term Extension of GTX-102 in Angelman Syndrome

for Angelman Syndrome

6 locations incl. Los Angeles

Sponsor: Ultragenyx Pharmaceutical Inc

Sex: All·Age: All ages

Code: NCT06415344·Phase 3·Enrolling By Invitation

Employment Support After Hematopoietic Stem Cell Transplantation

for Hematopoietic Stem Cell Transplantation

1 location in Boston

Sponsor: MGH Institute of Health Professions

Sex: All·Age: 18 - 70

Code: NCT06494423·Recruiting

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A Phase III Study to Investigate Efficacy, Safety and Tolerability of Iptacopan Compared With Placebo in Participants Aged 18 to 85 Years With gMG.

for Generalized Myasthenia Gravis

Drug: Iptacopan

21 locations incl. Scottsdale

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 85

Code: NCT06517758·Phase 3·Recruiting

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Long-term Safety and Tolerability of BHV-7000

for Focal Epilepsy

115 locations incl. Birmingham

Sponsor: Biohaven Therapeutics Ltd.

Sex: All·Age: 18 - 75

Code: NCT06443463·Phase 2·Enrolling By Invitation

A Multicenter Pediatric Deep Brain Stimulation Registry

for Dystonia

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 0 - 18

Code: NCT06585618·Recruiting

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Maximizing Lymph Node Dissection on Fresh and Fixed Lung Cancer Resection Specimens

for Lung Cancer

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06252129·Recruiting

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Study of GS-2121 Given Alone or in Combination in Adults With Advanced Solid Tumors

for Advanced Solid Tumors

4 locations incl. Palo Alto

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT06532565·Phase 1·Recruiting

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Integrative Mindfulness-Based Predictive Approach for Chronic Low Back Pain Treatment

for Chronic Low-back Pain

1 location in Boston

Sponsor: Boston Medical Center

Sex: All·Age: 18+

Code: NCT06106191·Recruiting

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PROPEL - A Prospective Observational Patient Registry to Evaluate ENPP1 and ABCC6 Deficiency

for Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 Deficiency

5 locations incl. Chicago

Sponsor: Inozyme Pharma

Sex: All·Age: All ages

Code: NCT06302439·Recruiting

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Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms

for Depressive Disorder, Major

Drug: Seltorexant

84 locations incl. Birmingham

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18 - 74

Code: NCT06559306·Phase 3·Recruiting

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ASSESS ALL ALS Study

for Amyotrophic Lateral Sclerosis

31 locations incl. Birmingham

Sponsor: St. Joseph's Hospital and Medical Center, Phoenix

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06578195·Recruiting

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PREVENT ALL ALS Study

for Amyotrophic Lateral Sclerosis

31 locations incl. Birmingham

Sponsor: St. Joseph's Hospital and Medical Center, Phoenix

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06581861·Recruiting

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Improving Outcomes and Reducing Disparities for Patients With Inflammatory Bowel Disease Through Epidemiology and Enhanced Disease Management

for Inflammatory Bowel Diseases

8 locations incl. San Diego

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 13+

Code: NCT06424769·Enrolling By Invitation

TRIcvalve biCAVal Valve System for Severe Tricuspid Regurgitation (TRICAV-I)

for Tricuspid Regurgitation

36 locations incl. Phoenix

Sponsor: P+F Products + Features USA Inc.

Sex: All·Age: 18+

Code: NCT06137807·Recruiting

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Exercise for Gut Microbiome in Patients With Young-Onset Colorectal Cancer Undergoing Chemotherapy: The COURAGE Trial

for Colorectal Cancer

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18 - 50

Code: NCT06202183·Recruiting

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A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)

for Relapsing Multiple Sclerosis

87 locations incl. Birmingham

Sponsor: TG Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06433752·Recruiting

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Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Tablet-01)

for Brainstem Stroke

1 location in Boston

Sponsor: Leigh R. Hochberg, MD, PhD.

Sex: All·Age: 18 - 80

Code: NCT06511934·Recruiting

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Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial

for Advanced Lung Non-Small Cell Carcinoma

318 locations incl. Fayetteville

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 70+

Code: NCT06096844·Phase 3·Recruiting

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Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy for Advanced HER2-positive Biliary Tract Cancer

for Biliary Tract Cancer

21 locations incl. Duarte

Sponsor: Jazz Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06282575·Phase 3·Recruiting

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PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

for High Grade Glioma

13 locations incl. Aurora

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 3 - 39

Code: NCT05096481·Phase 2·Recruiting

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A Study of NVL-330 in Patients With Advanced or Metastatic HER2-altered NSCLC (HEROEX-1)

for Locally Advanced Solid Tumor

17 locations incl. Irvine

Sponsor: Nuvalent Inc.

Sex: All·Age: 18+

Code: NCT06521554·Phase 1·Recruiting

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Letrozole in Uterine Leiomyosarcoma

for Uterine Leiomyosarcoma

25 locations incl. Aurora

Sponsor: GOG Foundation

Sex: Female·Age: 18+

Code: NCT05649956·Phase 2·Recruiting

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Comparative-effectiveness of a Healthy Lifestyle and Asthma Management Program, In-person vs. ONline

for Overweight, Childhood

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 4 - 17

Code: NCT06432790·Recruiting

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A Study of Telitacicept for the Treatment of Generalized Myasthenia Gravis (UPSTREAM MG)

for Generalized Myasthenia Gravis

Drug: Telitacicept

20 locations incl. Los Angeles

Sponsor: Vor Biopharma

Sex: All·Age: 18+

Code: NCT06456580·Phase 3·Recruiting

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A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease

for Anemia, Sickle Cell

13 locations incl. Birmingham

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06481306·Phase 1, Phase 2·Recruiting

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Blood Pressure Variability and Ischemic Stroke Outcome

for Acute Ischemic Stroke

3 locations incl. New Haven

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT05756257·Recruiting

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A Study Evaluating Atezolizumab, With or Without Bevacizumab, in Participants With Unresectable Hepatocellular Carcinoma and Child-pugh B7 and B8 Cirrhosis

for Hepatocellular Carcinoma

Drug: Atezolizumab

60 locations incl. Tucson

Sponsor: Genentech, Inc.

Sex: All·Age: 18+

Code: NCT06096779·Phase 2·Recruiting

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CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplant

for Acute Lymphoblastic Leukemia

3 locations incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT06059391·Phase 2·Recruiting

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A Study to Test the Effects and Safety of Riliprubart in People With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) for Which the Usual Treatments do Not Work

for Chronic Inflammatory Demyelinating Polyradiculoneuropathy

Drug: riliprubart

28 locations incl. Homewood

Sponsor: Sanofi

Sex: All·Age: 18+

Code: NCT06290128·Phase 3·Recruiting

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Exercise Training in Transthyretin Cardiac Amyloidosis

for Amyloid Cardiomyopathy

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 60 - 90

Code: NCT05797857·Recruiting

Apply to this trial

Modulation of Brain Oscillations Underlying Working Memory

for Working Memory

1 location in Charlestown

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 35·Accepts healthy volunteers

Code: NCT05923606·Recruiting

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Testing the Combination of the Anticancer Drug Durvalumab With Chemotherapy (Gemcitabine and Cisplatin) at Improving Outcomes for High-Risk Resectable Liver Cancer Before Surgery

for Resectable Intrahepatic Cholangiocarcinoma

Drug: Durvalumab

58 locations incl. Irvine

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06050252·Phase 2·Recruiting

Apply to this trial

Lumason® Infusion vs. Bolus Administrations

for Heart Diseases

6 locations incl. West Hills

Sponsor: Bracco Diagnostics, Inc

Sex: All·Age: 18+

Code: NCT06400004·Phase 3·Recruiting

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A Phase 1 Study of CTIM-76 in Patients With Recurring Ovarian Cancer and Other Advanced Solid Tumors

for Platinum-resistant Ovarian Cancer

13 locations incl. Little Rock

Sponsor: Context Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06515613·Phase 1·Recruiting

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Ivosidenib in Participants With Locally Advanced or Metastatic Conventional Chondrosarcoma Untreated or Previously Treated With 1 Systemic Treatment Regimen

for Locally Advanced or Metastatic Conventional Chondrosarcoma With an IDH1 Mutation, Untreated or Previously Treated With 1 Systemic Treatment Regimen

22 locations incl. Los Angeles

Sponsor: Servier Bio-Innovation LLC

Sex: All·Age: 18+

Code: NCT06127407·Phase 3·Recruiting

Apply to this trial

Study to Determine the Clinical Significance of Intravascular OCT-NIRAF

for Cardiovascular Diseases

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06374498·Enrolling By Invitation