Modulation of Brain Oscillations Underlying Working Memory

Part of paid clinical trials in Charlestown, Massachusetts.

Sponsor
Massachusetts General Hospital
Study ID
NCT05923606
Status
Recruiting
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Conditions

  • Working Memory

Eligibility Criteria

Sex
ALL
Age
18 Years - 35 Years
Healthy Volunteers
Accepted

Interventions

  • Active tACS — DEVICE
    Active tACS will be administered over the left dorsolateral prefrontal cortex for approximately 25 minutes.
  • Placebo tACS — DEVICE
    Placebo tACS will be administered over the left dorsolateral prefrontal cortex for approximately 25 minutes.

Study Details

This study will use novel transcranial alternating current stimulation (tACS) protocols and electroencephalography (EEG) to modulate and measure brain oscillations that underlie working memory. tACS is a noninvasive method used to modulate the timing and patterns of brain rhythms via weak electric currents passed through electrodes on the scalp.

Key Dates

Start date
Jul 10, 2024
Status verified
Feb 2026
Primary completion
Aug 31, 2026
Completion
Mar 31, 2027

Study Design

Enrollment
32 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Theta-nested gamma tACS applied during passive task epochs
    Participants will receive single-session administration of tACS during performance of a working memory task. tACS will be applied during fixation periods between consecutive task trials. EEG will be acquired before and immediately after the intervention.
  • Experimental: Theta-nested gamma tACS applied during memory delays
    Participants will receive single-session administration of tACS during performance of a working memory task. tACS will be applied during memory delays. EEG will be acquired before and immediately after the intervention.
  • Experimental: Gamma tACS applied during memory delays
    Participants will receive single-session administration of tACS during performance of a working memory task. tACS will be applied during memory delays. The stimulation will be phase locked to the peaks of ongoing theta rhythms of the participant. EEG will be acquired before and immediately after the intervention.
  • Placebo Comparator: Placebo tACS applied during task performance
    Participants will receive single-session administration of placebo tACS during performance of a working memory task. EEG will be acquired before and immediately after the intervention.

Primary Outcome Measure

Working memory accuracy [ Time Frame: 2 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Martinos Center for Biomedical ImagingCharlestownMassachusetts02129
Alexandra O'Neill, B.S.

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Martinos Center for Biomedical Imaging· Charlestown, MA

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