Causal Role of Top-Down Theta Oscillations in Prioritization

Part of paid clinical trials in Chapel Hill, North Carolina.

Sponsor
University of North Carolina, Chapel Hill
Study ID
NCT06252532
Status
Enrolling By Invitation

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • Direct cortical stimulation (DCS) Alpha — DEVICE
    Rhythmic alpha stimulation
  • Direct cortical stimulation (DCS) Theta — DEVICE
    Rhythmic theta stimulation applied
  • Sham Direct cortical stimulation (DCS) — DEVICE
    Arrhythmic stimulation paradigm applied
  • Direct cortical stimulation (DCS) In-Phase Theta — DEVICE
    Rhythmic in-phase theta stimulation applied
  • Direct cortical stimulation (DCS) Anti-Phase Theta — DEVICE
    Rhythmic anti-phase theta stimulation applied

Study Details

Purpose: The purpose of this pilot study is to investigate the dynamics between theta and alpha oscillations in the control of working memory. These findings will be informative of what types of brain stimulation are most effective at modulating brain activity. Deep brain stimulation and transcranial magnetic stimulation are used for an increasing number of neurological and psychiatric disorders. Participants: Eligible participants are patients who have previously had electrodes implanted to monitor epilepsy (outside of research activity). 50 participants will be recruited, 25 participants for each phase of the study. Procedures (methods): The participants will perform a cognitive control task. During the task, rhythmic trains of direct cortical stimulation will be delivered to the frontal cortex alone or to the frontal and parietal cortex. Electrocorticography will be collected concurrent with stimulation.

Key Dates

Start date
Jul 1, 2024
Status verified
Apr 2026
Primary completion
Jan 31, 2027
Completion
Jan 31, 2027

Study Design

Enrollment
50 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Active Comparator: Frontal Stimulation
    Direct Cortical Stimulation (DCS) in alpha and theta frequencies is applied through electrodes located in the frontal cortex.
  • Sham Comparator: Frontal Parietal Stimulation
    Direct Cortical Stimulation (DCS) in in-phase and anti-phase theta frequencies is applied through electrodes located in the frontal and parietal cortex.

Primary Outcome Measure

Change in Working Memory Task Performance - Pashler's working memory capacity metric (k) [ Time Frame: During the 1- to 1.5-hour test at Baseline and Stimulation Session conducted over a 1 to 2 day period ]

Locations (1)

FacilityCityStateZIPSite coordinators
University of North Carolina at Chapel HillChapel HillNorth Carolina27599-

Find similar trials in Chapel Hill, NC

By condition
Epilepsy
By specialty
NeurologyBrain disorders
By research site
University of North Carolina at Chapel Hill· Chapel Hill, NC

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