Acute Effects of Stimulant Medication in College Students With ADHD

Part of paid clinical trials in Laramie, Wyoming.

Sponsor
University of Wyoming
Study ID
NCT03935646
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 29 Years
Healthy Volunteers
Accepted

Interventions

  • Adderall IR 10mg — DRUG
    At one of the experimental appointments, participants will be administered a stimulant medication. Following a wait period, the participants will complete executive functioning tasks of working memory and sustained attention.
  • Placebo — DRUG
    Placebo

Study Details

The investigators will examine the acute effects of stimulant medication on executive functioning. The rationale for the proposed study is to examine the efficacy of stimulants for college students with ADHD and help prevent stimulant misuse among college students without ADHD. The working hypothesis is that stimulants, compared to baseline and placebo conditions, will improve executive functioning for college students with ADHD but not for college students without ADHD. Improvements on executive functioning measures (e.g., CPT-IP, Spatial Span) will be examined through 2 (ADHD vs. non-ADHD) x 3 (Baseline, Placebo, Stimulant) repeated measures ANOVAs. Follow-up analyses will include paired comparisons. Expected outcomes are to confirm these hypotheses and demonstrate the need for further study of stimulants. If confirmed, the results will provide pilot data for a larger NIH grant proposal aimed at further examining the acute effects of stimulants (i.e., improved cognitive functioning with stimulants) and comparing them to the acute effects of physical exercise (i.e., improved cognitive functioning immediately after exercise). The investigators expect this outcome to have an important positive impact because it can help support stimulant medication as an effective treatment for college students with ADHD (DuPaul et al., 2012). Additionally, demonstration that stimulants do not improve executive functioning for college students without ADHD can be used to help prevent and discourage stimulant misuse and diversion on college campuses (Hartung et al., 2013).

Key Dates

Start date
Feb 11, 2020
Status verified
Jun 2024
Primary completion
Jun 30, 2025
Completion
Jun 30, 2025

Study Design

Enrollment
40 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Stimulant Medication
    Participants will be administered a stimulant medication (Adderall IR 10mg). The ordering of experimental vs. placebo appointments will be counterbalanced. Participants will complete computer-based tests of sustained attention and working memory during all appointments.

Primary Outcome Measure

Change in Continuous Performance Test - Identical Pairs (CPT-IP) for Adderall vs. Placebo [ Time Frame: Completed at baseline and each experimental appointment over a period of three weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of WyomingLaramieWyoming82071
Cynthia M Hartung, Ph.D.
[email protected]
307-314-2123

Find similar trials in Laramie, WY

By condition
ADHD
By specialty
PsychiatryMental healthBehavioral health
By research site
University of Wyoming· Laramie, WY

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