NIMH K23: Modulation of Frontoparietal Dynamics in Adolescent Working Memory Deficits

Part of paid clinical trials in East Providence, Rhode Island.

Sponsor
Bradley Hospital
Study ID
NCT05662280
Status
Recruiting
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Conditions

  • Working Memory

Eligibility Criteria

Sex
ALL
Age
12 Years - 18 Years
Healthy Volunteers
Not accepted

Interventions

  • Active Intermittent Theta Burst Stimulation — DEVICE
    Standard iTBS protocol with active coil
  • Sham Intermittent Theta Burst Stimulation — DEVICE
    Standard iTBS protocol with active coil

Study Details

Working memory (WM) deficits are a transdiagnostic feature of adolescent psychopathology that substantially contribute to poor clinical and functional outcomes. This proposal will utilize a multimodal neuroscientific approach to investigate whether non-invasive brain stimulation can modulate the neural mechanisms underlying adolescent WM deficits. Directly in line with NIMH priorities, the researchers will identify the contributing roles of prefrontal and parietal regions in WM processes, as well as identify optimal targets and parameters for novel brain-based treatments in adolescent psychopathology. This study is funded by the NIMH-K23

Key Dates

Start date
Dec 1, 2022
Status verified
Aug 2025
Primary completion
Dec 1, 2026
Completion
Dec 1, 2026

Study Design

Enrollment
40 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Active intermittent Theta Burst Stimulation
    In a 2x2 factorial double-blind design, researchers will randomize a sample of adolescents with WM deficits to intermittent theta burst stimulation (iTBS) at the left dorsolateral prefrontal cortex (DLPFC) or inferior parietal lobule (IPL), based on each participant's structural brain MRI. Participants in both arms will complete an active iTBS session and a sham iTBS session. The primary outcome will be theta-gamma coupling during WM demands, as measured via electroencephalography (EEG) during a Sternberg spatial WM task (SWMT) immediately before and after iTBS.
  • Experimental: Sham intermittent Theta Burst Stimulation
    In a 2x2 factorial double-blind design, researchers will randomize a sample of adolescents with WM deficits to intermittent theta burst stimulation (iTBS) at the left dorsolateral prefrontal cortex (DLPFC) or inferior parietal lobule (IPL), based on each participant's structural brain MRI. Participants in both arms will complete an active iTBS session and a sham iTBS session. The primary outcome will be theta-gamma coupling during WM demands, as measured via electroencephalography (EEG) during a Sternberg spatial WM task (SWMT) immediately before and after iTBS.

Primary Outcome Measure

Change in Theta-Gamma Coupling After Sham iTBS [ Time Frame: Theta-gamma coupling will be obtained immediately before (i.e., pre-iTBS) and after iTBS (i.e., post-iTBS). There will be approximately 5 minutes between the pre and post EEG recordings. The change between pre-iTBS and post-iTBS is the outcome variable. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
E. P. Bradley HospitalEast ProvidenceRhode Island02915
Brian Kavanaugh, PsyD
[email protected]
401 432 1359

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E. P. Bradley Hospital· East Providence, RI

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