Letrozole in Uterine Leiomyosarcoma
Part of paid clinical trials in Aurora, Colorado.
- Sponsor
- GOG Foundation
- Study ID
- NCT05649956
- Phase
- PHASE2
- Status
- Recruiting
Conditions
- Uterine Leiomyosarcoma
Eligibility Criteria
- Sex
- FEMALE
- Age
- 18 Years - N/A
- Healthy Volunteers
- Not accepted
Interventions
- Letrozole — DRUGLetrozole 2.5 mg PO daily
Study Details
This is a clinical trial to test letrozole in patients with uterine leiomyosarcoma. The main question is will treatment with letrozole extend progression-free survival in patients. Patients will receive 2/5 mg of letrozole daily.
Key Dates
- Start date
- Jul 17, 2024
- Status verified
- Mar 2026
- Primary completion
- Jul 30, 2028
- Completion
- Jul 30, 2029
Study Design
- Enrollment
- 40 participants (estimated)
- Allocation
- RANDOMIZED
- Intervention model
- PARALLEL
- Primary purpose
- TREATMENT
Arms
- Experimental: LetrozoleLetrozole 2.5 mg orally
- No Intervention: ObservationObservation
Primary Outcome Measure
Progression Free Survival [ Time Frame: Measured from time of enrollment until date of progression or death up 3 years from randomization ]
Central Contacts
- Sarin Chhab2158540770
- Shanon Matkin
Locations (25)
| Facility | City | State | ZIP | Site coordinators |
|---|---|---|---|---|
| University of Colorado Cancer Center - Anschutz Cancer Pavilion | Aurora | Colorado | 80045 | Bradley Corr, MD (PRINCIPAL_INVESTIGATOR) |
| Highlands Ranch Hospital | Highlands Ranch | Colorado | 80129 | Bradley Corr, MD (PRINCIPAL_INVESTIGATOR) |
| Broward Health Medical Center | Fort Lauderdale | Florida | 33316 | Linda Borus Scott Jordan, MD (PRINCIPAL_INVESTIGATOR) |
| Mount Sinai Comprehensive Cancer Center | Miami Beach | Florida | 33140 | Yvonne Enriquez-Nunez Brian Slomovitz, MD (PRINCIPAL_INVESTIGATOR) |
| Winship Cancer Institute, Emory Hospital | Atlanta | Georgia | 30322 | Ashley Trumbull Susan Modesitt, MD (PRINCIPAL_INVESTIGATOR) |
| Endeavor Health - Kellogg Cancer Center | Evanston | Illinois | 60201 | Michele Britto Endeavor Health - Kellogg Cancer Center Jenkins-Vodel, MD (PRINCIPAL_INVESTIGATOR) |
| Indiana University Melvin and Bren Simon Comprehensive Cancer Center | Indianapolis | Indiana | 46202 | Grace Lander Lisa Landrum, MD (SUB_INVESTIGATOR) |
| LSU Health Sciences Center | New Orleans | Louisiana | 70112 | Carla Laborde Tara Castellano, MD (PRINCIPAL_INVESTIGATOR) |
| WK Physician Network-Gynecologic Oncology Associates | Shreveport | Louisiana | 71103 | Jennifer Cory Destin Black, MD (PRINCIPAL_INVESTIGATOR) |
| University of Massachusetts Memorial Medical Center | Worcester | Massachusetts | 01605 | Cara Gregoire Susan Zweizig, MD (PRINCIPAL_INVESTIGATOR) |
| University of Minnesota | Minneapolis | Minnesota | 55455 | Jordan Mattson, MD Jordan Mattson, MD (PRINCIPAL_INVESTIGATOR) |
| Women's Cancer Center of Nevada | Las Vegas | Nevada | 89106 | Jacky Amador Nicola Spirtos, MD (PRINCIPAL_INVESTIGATOR) |
| Women's Cancer Center of Nevada | Las Vegas | Nevada | 89511 | Shannon Pierpoint Peter Lim, MD (PRINCIPAL_INVESTIGATOR) |
| Atlantic Health System | Morristown | New Jersey | 07960 | Nana Tchabo, MD Nana Tchabo, MD (PRINCIPAL_INVESTIGATOR) |
| Overlook Medical Center | Summit | New Jersey | 07901 | Nana Tchabo, MD Nana Tchabo, MD (PRINCIPAL_INVESTIGATOR) |
| University of New Mexico Comprehensive Cancer Center | Albuquerque | New Mexico | 87131 | Mollie Dedig Carolyn Muller (PRINCIPAL_INVESTIGATOR) |
| East Carolina University Health Medical Center | Greenville | North Carolina | 27834 | Logan Ivey Grainger Lanneau, MD (PRINCIPAL_INVESTIGATOR) |
| OhioHealth Arthur G.H. Bing, MD Cancer Center | Columbus | Ohio | 43214 | Aine Clements, MD Aine Clements, MD (PRINCIPAL_INVESTIGATOR) |
| OhioHealth Grant Medical Center | Columbus | Ohio | 43215 | Aine Clements, MD Aine Clements, MD (PRINCIPAL_INVESTIGATOR) |
| OhioHealth Research Institute | Columbus | Ohio | 43214 | Aine Clements, MD Aine Clements, MD (PRINCIPAL_INVESTIGATOR) |
| OhioHealth Riverside Methodist Hospital | Columbus | Ohio | 43214 | Aine Clements, MD Aine Clements, MD (PRINCIPAL_INVESTIGATOR) |
| OhioHealth Marion General Hospital | Marion | Ohio | 43302 | Aine Clements, MD Aine Clements, MD (PRINCIPAL_INVESTIGATOR) |
| University of Oklahoma Health Stephenson Cancer Center | Oklahoma City | Oklahoma | 73104 | Laura Holman Laura Holman, MD (PRINCIPAL_INVESTIGATOR) |
| Asplundh Cancer Pavilion | Willow Grove | Pennsylvania | 19090 | Ashley Douglas Tommy Buchanan, MD (PRINCIPAL_INVESTIGATOR) |
| Woman and Infants Hospital of Rhode Island | Providence | Rhode Island | 02905 | Emma Locke Matthew Oliver, MD (PRINCIPAL_INVESTIGATOR) |
Find similar trials in Aurora, CO
By research site
University of Colorado Cancer Center - Anschutz Cancer Pavilion· Aurora, COHighlands Ranch Hospital· Highlands Ranch, COBroward Health Medical Center· Fort Lauderdale, FLMount Sinai Comprehensive Cancer Center· Miami Beach, FLWinship Cancer Institute, Emory Hospital· Atlanta, GAEndeavor Health - Kellogg Cancer Center· Evanston, IL
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