Paid Clinical Trials in Massachusetts

Massachusetts has 3,584 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 15, 2026.

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3,584 clinical trials

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Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

for Major Depressive Disorder

Drug: NBI-1065845

40 locations incl. Huntsville

Sponsor: Neurocrine Biosciences

Sex: All·Age: 18+

Code: NCT06966401·Phase 3·Recruiting

Apply to this trial

A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT)

for Stage I Mixed Cell Type Kidney Wilms Tumor

146 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 30

Code: NCT06401330·Phase 3·Recruiting

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Vascular Mechanisms, Functional Outcomes, & Exercise Among Persons With Multiple Sclerosis With Hypertension

for Multiple Sclerosis

1 location in Boston

Sponsor: University of Massachusetts, Boston

Sex: All·Age: 18+

Code: NCT06554340·Recruiting

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Precision Medicine in the CICU: Identifying Proteomic Biomarkers

for Congenital Heart Disease

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 2 Days - 5

Code: NCT06642662·Enrolling By Invitation

Phase 1/2 Study of PYX-201 in Combination With Pembrolizumab in Advanced Solid Tumors

for Advanced Solid Tumors

11 locations incl. San Diego

Sponsor: Pyxis Oncology, Inc

Sex: All·Age: 18+

Code: NCT06795412·Phase 1, Phase 2·Recruiting

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A Clinical Study of Raludotatug Deruxtecan in People With Ovarian Cancer (MK-5909-003)

for Ovarian Cancer Recurrent

8 locations incl. New Haven

Sponsor: Merck Sharp & Dohme LLC

Sex: Female·Age: 18+

Code: NCT06843447·Phase 1, Phase 2·Recruiting

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Enhanced Local Intensified Radiation Therapy in Elderly Glioblastoma: A Phase 2 Hybrid Randomized Trial

for Glioblastoma (GBM)

3 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 65+

Code: NCT06835803·Phase 2·Recruiting

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Observational Registry for Iltamiocel Compared to Placebo for Urinary Sphincter Repair in Post-surgical Female Stress Incontinence

for Stress Urinary Incontinence

1 location in Harvard

Sponsor: Cook MyoSite

Sex: Female·Age: 18 - 100

Code: NCT06743620·Enrolling By Invitation

A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)

for Lymphoma, Large B-Cell, Diffuse

Drug: Polatuzumab Vedotin

70 locations incl. Mobile

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06890884·Phase 2·Recruiting

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Evaluating the Efficacy and Safety of Saline Irrigation as an Add-On Therapy for Retained Pleural Infections [LYTICS +]

for Pleural Effusion Associated With Pulmonary Infection

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT06713382·Phase 2·Recruiting

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The DIAGNOSE CTE Research Project-II

for Chronic Traumatic Encephalopathy (CTE)

5 locations incl. Phoenix

Sponsor: Boston University

Sex: Male·Age: 50+·Accepts healthy volunteers

Code: NCT06860828·Enrolling By Invitation

Noninvasive Continuous BP Monitoring in Newborns Based on Pulsatile Signal Morphological Features Using NIRS

for Unstable Blood Pressure

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 24 Weeks - 44 Weeks

Code: NCT06994494·Recruiting

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Muscle Health Measurements Using Electrical Impedance Myography

for Myopathy

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18 - 89·Accepts healthy volunteers

Code: NCT07502989·Recruiting

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Assessing the Efficacy of Repeat, Monthly Treatments of Deoxycholate for NF1 Associated Cutaneous Neurofibromas (cNFs)

for Neurofibromas, Cutaneous

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 85

Code: NCT06300502·Phase 1·Enrolling By Invitation

Remote Tai Chi for Knee Osteoarthritis

for Knee Osteoarthritis

1 location in Boston

Sponsor: Tufts Medical Center

Sex: All·Age: 50 - 100

Code: NCT06384898·Recruiting

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Proof-of-Concept Testing of the Cardiovascular Health Equity Through Food (CHEF) Intervention in Childhood Cancer Survivors

for Childhood Cancer

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: Up to 18

Code: NCT06609473·Recruiting

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AMX0114 in Adult Participants With Amyotrophic Lateral Sclerosis

for ALS

10 locations incl. La Jolla

Sponsor: Amylyx Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT06665165·Phase 1·Recruiting

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CardiolRx in Recurrent Pericarditis (MAVERIC Phase-3)

for Recurrent Pericarditis

21 locations incl. Phoenix

Sponsor: Cardiol Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06708299·Phase 3·Recruiting

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TMS for Cognitive Decline in Aging and Preclinical AD

for Prodromal Alzheimer&#39

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 40 - 99·Accepts healthy volunteers

Code: NCT06956300·Recruiting

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Patiromer for Treatment of Hyperkalaemia in Children Under 12 Years of Age

for Hyperkalemia

Drug: patiromer

13 locations incl. Aurora

Sponsor: Vifor Pharma, Inc.

Sex: All·Age: 0 - 11

Code: NCT05766839·Phase 2·Recruiting

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FORWARD CAD IDE Study

for Coronary Arterial Disease (CAD)

28 locations incl. La Jolla

Sponsor: Shockwave Medical, Inc.

Sex: All·Age: 18+

Code: NCT06662500·Recruiting

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Ear-Seizure Detection (EarSD) Study

for Seizures

2 locations incl. Worcester

Sponsor: Felicia Chu

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06598189·Recruiting

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Study of ECI830 Single Agent or in Combination in Patients With Advanced HR+/HER2- Breast Cancer and Other Advanced Solid Tumors

for Advanced HR+/HER2- Breast Cancer

8 locations incl. Los Angeles

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100

Code: NCT06726148·Phase 1, Phase 2·Recruiting

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Retropubic Hydrodissection and Trocar-induced Bladder Perforation During Retropubic Midurethral Slings

for Bladder Perforation

1 location in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT07208682·Recruiting

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A Study of Tacrolimus/Methotrexate/Ruxolitinib Versus Post-Transplant Cyclophosphamide/Tacrolimus/Mycophenolate Mofetil in Non-Myeloablative/Reduced Intensity Conditioning Allogeneic Peripheral Blood Stem Cell Transplantation (BMT CTN 2203)

for Graft-versus-host Disease (GVHD)

Drug: Ruxolitinib

30 locations incl. Palo Alto

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT06615050·Phase 3·Recruiting

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G-CSF After Chemo-radiation in Patients With Glioblastoma

for MGMT-Methylated Glioblastoma

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06649851·Phase 2·Recruiting

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Caries Detection With Two Different Caries Detecting Devices

for Caries,Dental

1 location in Boston

Sponsor: Tufts University

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT06152081·Recruiting

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Effectiveness of Cognitive Training in Older and Younger Adults

for Cognitive Change

3 locations incl. Riverside

Sponsor: University of Wisconsin, Madison

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT06375681·Recruiting

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Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial

for Lung Non-Small Cell Carcinoma

243 locations incl. Jonesboro

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06498635·Phase 3·Recruiting

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Bedtime Stories: Tailored Sleep Health Messaging for Caregivers

for Sleep

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06618040·Recruiting

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Treatment of Post Traumatic Knee Osteoarthritis With Extracorporeal Shockwave Therapy

for Knee Osteoarthristis

1 location in Cambridge

Sponsor: Spaulding Rehabilitation Hospital

Sex: All·Age: 18 - 55

Code: NCT06686680·Recruiting

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EQUAL: EGFR ctDNA QUantative Assessment for Lung Cancer Screening in Asian and Latinx Populations

for Lung Cancer

6 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 40 - 80·Accepts healthy volunteers

Code: NCT06716580·Recruiting

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Computerized Decision Support for Identification and Management of Familial Hypercholesterolemia

for Familial Hypercholesterolaemia

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: All ages

Code: NCT06743659·Recruiting

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ExCrossV Multi Site Trial for Vascularized High Risk Keratoplasty

for Corneal Transplant Failure

12 locations incl. Irvine

Sponsor: Massachusetts Eye and Ear Infirmary

Sex: All·Age: 18+

Code: NCT06753916·Phase 2·Recruiting

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Pharmacologic Augmentation of TMS for Depression With D-serine

for Depression

1 location in Belmont

Sponsor: Mclean Hospital

Sex: All·Age: 18 - 80

Code: NCT06876129·Phase 1·Recruiting

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Pelvic Vein Quantitative Flow Characterization Using 2D and 4D Flow MRI

for May-Thurner Syndrome

1 location in Worcester

Sponsor: Ningcheng Peter Li

Sex: All·Age: 18 - 89·Accepts healthy volunteers

Code: NCT06888024·Recruiting

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Tools for Reducing Inequity in Acute Leukemia (TRIAL): Beta Testing

for Acute Leukemia

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06907797·Recruiting

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Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain

for Amputation

4 locations incl. Pittsfield

Sponsor: AtriCure, Inc.

Sex: All·Age: 18+

Code: NCT06908538·Recruiting

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Perioperative Anticoagulant Use for Surgery Evaluation -2 (PAUSE-2) Study Patients Receiving a Direct Oral Anticoagulant (DOACs-Dabigatran, Rivaroxaban, Apixaban or Edoxaban) and Needing Elective High-Bleed-Risk Surgery or an Invasive Procedure

for Atrial Fibrillation (AF)

6 locations incl. Hartford

Sponsor: McMaster University

Sex: All·Age: 18+

Code: NCT06957366·Recruiting

Apply to this trial

Risk Informed Obesity Care Plan Pilot

for Childhood Obesity

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 2 - 12

Code: NCT07028814·Enrolling By Invitation