Paid Clinical Trials in Massachusetts

Massachusetts has 3,584 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 15, 2026.

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3,584 clinical trials

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Direct to Patient Minimal Risk Biospecimen and Data Collection Research

for Healthy

1 location in Lexington

Sponsor: Joined Bio

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT07128966·Recruiting

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Evaluation of Multi-Cancer Early Detection Testing in a High-Risk Military Population: The Sentinel Study

for Cancer Diagnosis

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 45+·Accepts healthy volunteers

Code: NCT06523868·Recruiting

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A Study of PHST001 in Advanced Solid Tumors

for Advanced Solid Tumors

20 locations incl. Beverly Hills

Sponsor: Pheast Therapeutics

Sex: All·Age: 18+

Code: NCT06840886·Phase 1·Recruiting

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NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

for Major Depressive Disorder

Drug: NBI-1065845

10 locations incl. Huntsville

Sponsor: Neurocrine Biosciences

Sex: All·Age: 18+

Code: NCT06911112·Phase 3·Recruiting

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BBO-11818 in Adult Subjects With KRAS Mutant Cancer

for Non-Small Cell Lung Cancer

16 locations incl. Los Angeles

Sponsor: TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)

Sex: All·Age: 18+

Code: NCT06917079·Phase 1·Recruiting

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Safety and Effectiveness of ELLANSÉ®-S Dermal Filler in the Treatment of Nasolabial Folds

for Nasolabial Folds

7 locations incl. Scottsdale

Sponsor: AQTIS Medical B.V.

Sex: All·Age: 22+

Code: NCT06984835·Recruiting

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Evaluating the Efficacy of RELiZORB in Managing Exocrine Pancreatic Insufficiency in Tube-fed Pancreatitis Patients

for Exocrine Pancreatic Insufficiency (EPI)

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06691893·Phase 3·Recruiting

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A Phase 2 Study of PTX 100 in Patients With Relapsed/Refractory CTCL

for CTCL

6 locations incl. Duarte

Sponsor: Prescient Therapeutics, Ltd.

Sex: All·Age: 18+

Code: NCT06854653·Phase 2·Recruiting

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Mind Body Intervention for Chronic Upper Extremity Pain (Repetitive Stress Injury)

for Chronic Pain

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18 - 60

Code: NCT06903962·Recruiting

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A Study of Vedolizumab in Adults With Ulcerative Colitis or Crohn's Disease in the Community Setting

for Ulcerative Colitis

100 locations incl. Birmingham

Sponsor: Takeda

Sex: All·Age: 18 - 80

Code: NCT06581328·Phase 4·Recruiting

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Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

for Metastatic Head and Neck Squamous Cell Carcinoma

177 locations incl. Little Rock

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06589804·Phase 3·Recruiting

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A Study of Ziftomenib in Combination With Imatinib in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)

for Gastrointestinal Stromal Tumor (GIST)

32 locations incl. Birmingham

Sponsor: Kura Oncology, Inc.

Sex: All·Age: 18+

Code: NCT06655246·Phase 1·Recruiting

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Integrating Pain-CBT Into an mHealth Analgesic Support Intervention for Patients With Chronic Pain From Advanced Cancers

for Pain

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 22+

Code: NCT06722014·Recruiting

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Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

for Carcinoma, Non-Small-Cell Lung

Drug: LY3537982

85 locations incl. Huntsville

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06890598·Phase 3·Recruiting

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DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

for Endometrial Cancer

Drug: Rilvegostomig

60 locations incl. Tucson

Sponsor: AstraZeneca

Sex: Female·Age: 18+

Code: NCT06989112·Phase 3·Recruiting

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Safety, Pharmacokinetics, and Efficacy of AI-081, a Bispecific Antibody for PD-1 And VEGF in Advanced Solid Tumors

for Advanced Solid Tumor

Drug: AI-081

19 locations incl. Birmingham

Sponsor: OncoC4, Inc.

Sex: All·Age: 18+

Code: NCT06635785·Phase 1, Phase 2·Recruiting

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A Study With NKT5097 for Adults With Advanced/Metastatic Solid Tumors

for HR+ Breast Cancer

14 locations incl. La Jolla

Sponsor: NiKang Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07029399·Phase 1·Recruiting

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Project EMPOWER-OCD

for Obsessive-Compulsive Disorder

1 location in Boston

Sponsor: Boston University Charles River Campus

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07158801·Recruiting

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Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

for Non Small Cell Lung Cancer

15 locations incl. Scottsdale

Sponsor: Tango Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06810544·Phase 1, Phase 2·Recruiting

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A Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of ALD-102 Solution in Subjects With Alopecia Areata

for Alopecia Areata (AA)

4 locations incl. Thousand Oaks

Sponsor: Aldena Therapeutics

Sex: All·Age: 18 - 55

Code: NCT06826196·Phase 1, Phase 2·Recruiting

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A Study of Invikafusp Alfa (STAR0602), a Selective T Cell Receptor (TCR)-Targeting, Bifunctional Antibody-fusion Molecule, in Combination With Sacituzumab Govitecan in Participants With Advanced Solid Tumors

for Triple Negative Locally Advanced Non-resectable Breast Cancer

6 locations incl. Los Angeles

Sponsor: Marengo Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06827613·Phase 1, Phase 2·Recruiting

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ctDNA in Cutaneous Squamous Cell Carcinoma

for Cutaneous Squamous Cell Carcinoma

1 location in Boston

Sponsor: Massachusetts Eye and Ear Infirmary

Sex: All·Age: 18+

Code: NCT06875609·Recruiting

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PEEL-224, Vincristine and Temozolomide in Pediatric Solid Tumors

for Refractory Solid Tumors

7 locations incl. Los Angeles

Sponsor: Theodore Laetsch

Sex: All·Age: 1 - 30

Code: NCT06721689·Phase 1, Phase 2·Recruiting

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Chiropractic Care for Episodic Migraine

for Episodic Migraine

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 65

Code: NCT06229834·Recruiting

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Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Addition of an Anti-cancer Drug, Topotecan, to the Usual Treatment for Types II and III Pleuropulmonary Blastoma

for Pleuropulmonary Blastoma

76 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT06647953·Phase 3·Recruiting

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A Study of PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors

for MTAP-deleted Solid Tumors

17 locations incl. Birmingham

Sponsor: Bayer

Sex: All·Age: 18+

Code: NCT06914128·Phase 1, Phase 2·Recruiting

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Novel Wrist Sensor System to Promote Hemiparetic Arm Use in Home Daily Life of Chronic Stroke Survivors

for Stroke

1 location in Boston

Sponsor: Spaulding Rehabilitation Hospital

Sex: All·Age: 18 - 85

Code: NCT05626894·Phase 2·Recruiting

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A Randomized Phase 2 Trial of Nivolumab, Relatlimab Plus Ipilimumab vs. Nivolumab Plus Ipilimumab in First-line Advanced Renal Cell Carcinoma (RCC)

for Renal Cell Carcinoma, Clear Cell

Drug: Ipilimumab

6 locations incl. Boston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06708949·Phase 2·Recruiting

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A Study of Navenibart in Participants With Hereditary Angioedema

for Hereditary Angioedema (HAE)

Drug: navenibart

19 locations incl. Birmingham

Sponsor: Astria Therapeutics, Inc.

Sex: All·Age: 12+

Code: NCT06842823·Phase 3·Enrolling By Invitation

Romosozumab as an Adjunct to Physiologic Estrogen Replacement in Functional Hypothalamic Amenorrhea

for FHA (Functional Hypothalamic Amenorrhea)

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 14 - 30

Code: NCT06533865·Phase 3·Recruiting

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Roginolisib (IOA-244) With Venetoclax and Rituximab for Refractory/Relapsed Chronic Lymphocytic Leukemia (CLL)

for Leukemia

Drug: Venetoclax

1 location in Boston

Sponsor: Jennifer R. Brown, MD, PhD

Sex: All·Age: 18+

Code: NCT06644183·Phase 1, Phase 2·Recruiting

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Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01)

for Ovarian Cancer

Drug: Bevacizumab

28 locations incl. La Jolla

Sponsor: Daiichi Sankyo

Sex: Female·Age: 18+

Code: NCT06819007·Phase 3·Recruiting

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A Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque PsO and Obesity or Overweight in Clinical Practice (TOGETHER AMPLIFY-PsO)

for Psoriasis

Drug: Tirzepatide

40 locations incl. Phoenix

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06857942·Phase 4·Recruiting

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Personalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial)

for Advanced Malignant Solid Neoplasm

27 locations incl. Duarte

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06311214·Phase 2·Recruiting

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Ziftomenib in Combination With Chemotherapy for Children With Relapsed/Refractory Acute Leukemia

for Relapsed/Refractory KMT2A-r Acute Leukemia

11 locations incl. Los Angeles

Sponsor: PedAL BCU, LLC

Sex: All·Age: 0 - 21

Code: NCT06376162·Phase 1·Recruiting

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Safety and Performance Assessment of the Sphere-9™ Catheter and Affera™ Ablation System for the Treatment of Ventricular Tachycardia (Sphere-9 VT EFS)

for Ventricular Tachycardia (VT)

6 locations incl. Boston

Sponsor: Medtronic Cardiac Ablation Solutions

Sex: All·Age: 18 - 85

Code: NCT06703489·Recruiting

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A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00006)

for Chronic Obstructive Pulmonary Disease (COPD)

67 locations incl. Foley

Sponsor: AstraZeneca

Sex: All·Age: 40 - 80

Code: NCT06883305·Phase 3·Recruiting

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An Open-Label Study of Azetukalner in Major Depressive Disorder

for Major Depressive Disorder

63 locations incl. Phoenix

Sponsor: Xenon Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT06922110·Phase 3·Enrolling By Invitation

Diabetes Management Using Continuous Glucose Monitors and Remote Patient Monitoring in Underserved Populations

for Type 2 Diabetes Mellitus (T2DM)

1 location in Greenfield

Sponsor: Diabetes Solutions International

Sex: All·Age: 18+

Code: NCT06939413·Recruiting

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Imeroprubart in Adult Participants With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

for Chronic Inflammatory Demyelinating Polyneuropathy

31 locations incl. Tucson

Sponsor: Immunovant Sciences GmbH

Sex: All·Age: 18+

Code: NCT07032662·Phase 2·Recruiting

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